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2009 | 18 | 5 |

Tytuł artykułu

Effects of elevated levels of manganese and iron in drinking water on birth outcomes

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
We examined the impact of elevated exposure levels of pregnant women to manganese and iron through drinking water on pregnancy outcomes. We conducted an epidemiological study among 16,408 pregnant women of Kaunas. We assessed each woman at her residence for exposure to manganese and iron levels measured in four Kaunas public water supply networks. We used a logistic regression to model the association between drinking water quality and birth outcomes controlling the confounding variables. Analysis yielded an increase in adjusted odds ratios (AOR) for term low birth weight (LBW) for moderate exposure level, 1.53 (95% confidence interval (CI) 0.89-2.66); and 1.70 (95% CI 1.07-2.71) for high exposure level. Maternal exposure was associated with a mean reduction of 21 g (SE, 9 g; p=0.02) in birth weight. No associations were observed between manganese and iron levels and preterm birth. These findings suggest that elevated levels of manganese and iron in drinking water are associated with a reduction in birth weight in term-born infants. However, further individual-level epidemiologic studies are necessary to investigate the factors that contribute to the increased sensitivity of some pregnant women.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

18

Numer

5

Opis fizyczny

p.819-825,ref.

Twórcy

  • Department of Environmental Sciences, Vytautas Magnus University, Donelaicio 58, 44248-LT Kaunas, Lithuania
  • Department of Obstetrics and Gynecology, Kaunas University of Medicine, Eiveniu 4, 50167-LT Kaunas, Lithuania
  • Department of Obstetrics and Gynecology, Kaunas University of Medicine, Eiveniu 4, 50167-LT Kaunas, Lithuania
  • Department of Environmental Sciences, Vytautas Magnus University, Donelaicio 58, 44248-LT Kaunas, Lithuania

Bibliografia

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  • 2. The Council of the European Union. Council Directive 98/83/EC on the quality of water intended for human consumption. 1998.
  • 3. Institute of Medicine Food and Nutrition Board. Dietary Reference Intakes: Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington DC: National Academy Press. 2002.
  • 4. ATSDR. Toxicological Profile for Manganese. Atlanta, GA: Agency for Toxic Substances and Disease Registry. 2000.
  • 5. GERBER G.B., LÉONARD A., HANTSON P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit. Rev. Oncol. Hematol. 42, (1), 25, 2002.
  • 6. MERGLER D., BALDWIN M., BELANGER S., LARRIBE F., BEUTER A., BOWLER R., PANISSET M., EDWARDS R., DE GEOFFROY A., SASSINE M.P., HUDNELL K. Manganese neu- rotoxicity a continuum of dysfunction: results from a com- munity based study. Neurotoxicology. 20, (2-3), 327, 1999.
  • 7. DOBSON A.W., ERIKSON K.M., ASCHNER M. Manganese neurotoxicity. Ann. N.Y. Acad. Sci. 1012, 115, 2004.
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  • 10. ERIKSON K.M., DORMAN D.C., FITSANAKIS V.A., LASH L.H., ASCHNER M. Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese. Biol. Trace Res. 111, (1-3), 199, 2006.
  • 11. TAYLOR M.D., ERIKSON K.M., DOBSON A.W., FITSANAKIS V.A., DORMAN, D.C., ASCHNER. M. Effects of inhaled manganese biomarkers of oxidative stress in the rat brain. Neurotoxicology. 27, (5), 788, 2006.
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  • 15. BOUCHARD M., LAFOREST F., VANDELAC L., BELLINGER D., MERGLER D. Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water. Environ. Health Perspect. 115, 122, 2007.
  • 16. SAHNI V., LEGER Y., PANARO L., ALLEN M., GIFFIN S., FURI D., HAMM N. Case report: a metabolic disorder presenting as pediatric manganism. Environ. Health Persp. 115, (12), 1776, 2007.
  • 17. WASSERMAN G.A., LIU X., PARVEZ F., AHSAN H., LEVY D., FACTOR-LITVAK P., KLINE J., VAN GEEN A., SLAVKOVICH V., LOIACONO N.J., CHENG Z., ZHENG Y., GRAZIANO J.H. Water manganese exposure and children’s intellectual function in Araihazar, Bangladesh. Environ. Health Perspect. 114, 124, 2006.
  • 18. KONDAKIS X.G., MAKRIS N., LEOTSINIDIS M., PRINOU M., PAPAPETROPOULOS T. Possible health effects of high manganese concentration in drinking water. Arch. Environ. Health. 44, (3), 175, 1989.
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  • 20. HAMAI D., BONDY S. Oxidative basis of manganese neurotoxicity. Ann. N. Y. Acad. Sci. 1012, 129, 2004.
  • 21. DORMAN D., MCELVEEN A.M., MARSHALL M.W., PARKINSON C.U., JAMES R.A., STRUVE M.F., WONG B.A. Tissue manganese concentrations in lactating rats and their offspring following combined in utero and lactation expo- sure to inhaled manganese sulfate. Toxicol. Sci. 84, (1), 12, 2005.
  • 22. DORMAN D.C., STRUVE M.F., VITARELLA D., BYERLY F.L., GOETZ J., MILLER R. Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. J. Appl. Toxicol. 20, (3), 179, 2000.
  • 23. PAPPAS B.A., ZHANG D., DAVIDSON C.M., CROWDER T., PARK G.A., FORTIN T. Perinatal manganese exposure: behavioral, neurochemical, and histopathological effects in the rat. Neurotoxicol. Teratol. 19, (1), 17, 1997.
  • 24. JADHAV S.H., SARKAR S.N., KATARIA M., TRIPATHI H.C. Subchronic exposure to a mixture of groundwater-contaminating metals though drinking water induces oxidative stress in male rats. Environ. Toxicol. Pharmacol. 23, 205, 2007.
  • 25. JADHAV S.H., SARKAR S.N., PATIL R.D., TRIPATHI H.C. Effects of subchronic exposure via drinking water to a mixture of eight water contaminating metals: a biochemical and histopathological study in male rats. Arch. Environ. Contam. Toxicol. 53, (4), 667, 2007.
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  • 30. HAFEMAN D., FACTOR-LITVAK P., CHENG Z., GEEN A., AHSAN H. Association between manganese exposure through drinking water and infant mortality in Bangladesh. Environ. Health Perspect. 115, (7), 1107, 2007.
  • 31. NIEUWENHUIJSEN M.J., TOLEDANO M.B., EATON N.E., FAWELL J., ELLIOTT P. Chlorination disinfection by-products in water and their association with adverse reproductive outcome: a review. Occup. Environ. Med. 57, 73, 2000.
  • 32. LJUNG K., VAHTER M. Time to re-evaluate the guideline value for manganese in drinking water? Environ. Health Perspect. 115, (11), 1533, 2007.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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