The effect of frontal cortex lesion on the activity of the dopaminergic system in rat striatum

• Autorzy: Sieklucka-Dziuba M. , Wamil A. , Kleinrok Z.
• Języki publikacji: EN

Abstrakty

EN

Sieklucka-Dziuba, M., Wamil, A., Kleinrok, Z.: The effect of frontal cortex lesion on the activity of the dopaminergic system in rat. striatum. Acta physiol, pol., 1988, 39 (4): 254-260. The experiment was carried out on male Wistar rats weighing 180-220 g with lesion in the cortex of the frontal lobe. The activity of the dopaminergic system was studied by means of behavioural tests such as determination of spontaneous motor activity, apomorphine-induced stereotypy,haloperidol-induced catalepsy. Increased intensity of stereotypy was observed reaching a maximum 14 days after frontal lobe damage. Moreover, a slight tendency was observed lor inhibition of haloperidol-induced catalepsy without changes in the spontaneous motor activity of the animals. Biochemical investigations demonstrated reduced dopamine content in the striatum on the side of the lesion.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1988
• Tom: 39
• Numer: 4
• Opis fizyczny: p.254-260,fig.,ref.

Twórcy

autor

Sieklucka-Dziuba M.

• Department of Pharmacology, School of Medicine, Lublin, Poland

autor

Wamil A.

• Department of Pharmacology, School of Medicine, Lublin, Poland

autor

Kleinrok Z.

• Department of Pharmacology, School of Medicine, Lublin, Poland

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