Cannabinoid CBI receptor antagonist rimonabant attenuates reinstatement de nicotine place preference provoked by nicotine or morphine in rats

• Autorzy: Biala G. , Budzynska B. , Staniak N.
• Języki publikacji: EN

Abstrakty

EN

Reinstatement of drug-seeking behaviour in animals is relevant to relapse to drug taking in humans. In the present study, we used the conditioned place preference paradigm to investigate the establishment, extinction, reinstatement and cross-reinstatement of nicotine-induced place conditioning in rats. We have revealed that nicotine produced a place preference to the compartment paired with its injections during conditioning. Once established, nicotine place preference was extinguished by repeated testing. Following this extinction phase, nicotine-experienced rats were challenged with nicotine (0.5 mg/kg) or morphine (10 mg/kg). These priming injections of both drugs renewed a marked preference for the compartment previously paired with nicotine. In the second step, we examined the infl uence of CB1 cannabinoid receptor antagonist rimonabant (0.5, 1 and 2 mg/kg) on the reinstatement of nicotine place conditioning. It was shown that rimonabant, dosedependently, attenuated the reinstatement of nicotine-conditioned response. Our fi ndings may further indicate similar endocannabinoid-dependent mechanisms involved in the development of reinstatement of nicotine-conditioned place preference provoked by priming injections of nicotine and morphine. As reinstatement of drug-seeking is a factor for the development of drug dependence, CB1 receptor antagonists may be useful in the relapse-prevention phase of addiction treatment, including nicotinism and polydrug abuse.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.349

Twórcy

autor

Biala G.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Budzynska B.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Staniak N.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland