Cerebral hypoperfusion in autism spectrum disorder

• Autorzy: Bjorklund G. , Kern J.K. , Urbina M.A. , Saad K. , El-Houfey A. , Geier D.A. , Chirumbolo S. , Geier M.R. , Mehta J.A. , Aaseth J.
• Języki publikacji: EN

Abstrakty

EN

Cerebral hypoperfusion, or insufficient blood flow in the brain, occurs in many areas of the brain in patients diagnosed with autism spectrum disorder (ASD). Hypoperfusion was demonstrated in the brains of individuals with ASD when compared to normal healthy control brains either using positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The affected areas include, but are not limited to the: prefrontal, frontal, temporal, occipital, and parietal cortices; thalami; basal ganglia; cingulate cortex; caudate nucleus; the limbic system including the hippocampal area; putamen; substantia nigra; cerebellum; and associative cortices. Moreover, correlations between symptom scores and hypoperfusion in the brains of individuals diagnosed with an ASD were found indicating that the greater the autism symptom pathology, the more significant the cerebral hypoperfusion or vascular pathology in the brain. Evidence suggests that brain inflammation and vascular inflammation may explain a part of the hypoperfusion. There is also evidence of a lack of normal compensatory increase in blood flow when the subjects are challenged with a task. Some studies propose treatments that can address the hypoperfusion found among individuals diagnosed with an ASD, bringing symptom relief to some extent. This review will explore the evidence that indicates cerebral hypoperfusion in ASD, as well as the possible etiological aspects, complications, and treatments.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2018
• Tom: 78
• Numer: 1
• Opis fizyczny: p.21-29,ref.

Twórcy

autor

Bjorklund G.

• Council for Nutritional and Environmental Medicine, Mo i Rana, Norway

autor

Kern J.K.

• Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA
• CONEM US Autism Research Group, Allen, TX, USA

autor

Urbina M.A.

• Departamento de Zoología, Facultad de Ciencias Naturales y Oceanograficas, Universidad de Concepcion, Casilla 160‑C, Concepcion, Chile

autor

Saad K.

• Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt

autor

El-Houfey A.

• Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt

autor

Geier D.A.

• Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA
• CoMeD, Inc., Silver Spring, MD, USA

autor

Chirumbolo S.

• Department of Neurological and Movement Sciences, University of Verona, Verona, Italy

autor

Geier M.R.

• Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA
• CoMeD, Inc., Silver Spring, MD, USA

autor

Mehta J.A.

• Department of Communication Sciences and Disorders, Texas Woman’s University, Denton, Texas, USA

autor

Aaseth J.

• Faculty of Public Health, Inland Norway University of Applied Sciences, Elverum, Norway
• Department of Research, Innlandet Hospital Trust, Brumunddal, Norway

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Identyfikatory

DOI

10.21307/ane‑2018‑005