Lycopene as a guardian of redox signalling

• Autorzy: Palozza P. , Catalano A. , Simone R. , Cittadini A.
• Języki publikacji: EN

Abstrakty

EN

It has been suggested that lycopene, the major carotenoid found in tomato, exhibits health-beneficial effects by virtue of its antioxidant activity. However, recent literature suggests that lycopene can actually "perform" roles independent of such capacity and involving a direct modulation of redox signalling. Reactive oxygen species are known to act as second messengers in the modulation of cellular signalling leading to gene expression changes and pharmacological responses. Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-κB and AP-1, Nrf2.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 1
• Opis fizyczny: p.21-25,fig.,ref.

Twórcy

autor

Palozza P.

• Institute of General Pathology, Catholic University, School of Medicine, Rome, Italy

autor

Catalano A.

autor

Simone R.

autor

Cittadini A.

Bibliografia

• Astorg P, Gradelet S, Berges R, Suschetet M (1997) Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat. Nutr Cancer 29: 60-68. 
• Aung HH, Vasu VT, Valacchi G, Corbacho AM, Kota RS, Lim Y, Obermueller-Jevic UC, Packer L, Carroll E, Cross CE, Gohil K (2009) Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures. Genes Nutr 4: 23-39. 
• Ben-Dor A, Steiner M, Gheber L, Danilenko M, Dubi N, Linnewiel K, Zick A, Sharoni Y, Levy J (2005) Carotenoids activate the antioxidant response element transcription system. Mol Cancer Ther 4: 177-186. 
• Böhm F, Edge R, Burke M, Truscott TG (2001) Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide - ROS components from cigarette smoke. J Photochem Photobiol B 64: 176-178. 
• Breinholt V, Lauridsen ST, Daneshvar B, Jakobsen J (2000) Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat. Cancer Lett 154: 201-210. 
• Chan CM, Fang JY, Lin HH, Yang CY, Hung C (2009) Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K Akt and MAPK pathways. Biochem Biophys Res Commun 388: 172-176. 
• Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, van Breemen R, Ashton D, Bowen PE (2001) Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J Natl Cancer Inst 93: 1872-1879. 
• De Stefano D, Maiuri MC, Simeon V, Grassia G, Soscia A, Cinelli MP, Carnuccio R (2007) Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-γ. Eur J Pharmacol 566: 192-199. 
• Devaraj S, Mathur S, Basu A, Aung HH, Vasu VT, Meyers S, Jialal I. (2008) A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress. J Am Coll Nutr 27: 267-273. 
• Di Mascio P, Kaiser S, Sies H (1989) Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 274: 532-538. 
• Erdman JW Jr, Ford NA, Lindshield BL (2009) Are the health attributes of lycopene related to its antioxidant function? Arch Biochem Biophys 483: 229-235.  
• Giovannucci E (1999) Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J Natl Cancer Inst 91: 317-331.  
• Goo YA, Li Z, Pajkovic N, Shaffer S, Taylor G, Chen J, Campbell D, Arnstein L, Goodlett DR, van Breemen RB (2007) Systematic investigation of lycopene effects in LNCaP cells by use of novel large-scale proteomic analysis software. Proteomics Clin Appl 1: 513-523. 
• Hazai E, Bikádi Z, Zsila F, Lockwood SF (2006) Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. Bioorg Med Chem 14: 6859-6867. 
• Huang CS, Fan YE, Lin CY, Hu ML (2007) Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1. J Nutr Biochem 18: 449-456. 
• Hung CF, Huang TF, Chen BH, Shieh JM, Wu PH, Wu WB (2008) Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. Eur J Pharmacol 586: 275-282. 
• Joo YE, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C (2009) Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS One 4: e4562-4573. 
• Karas M, Amir H, Fishman D, Danilenko M, Segal S, Nahun A, Koifman A, Giat Y, Levy J, Sharoni Y (2000) Lycopene interferes with cell cycle progression and insuline-growth factor I signalling in mammary cancer cells. Nutr Cancer 36: 101-111. 
• Kim GY, Kim JH, Ahn SC, Lee HJ, Moon DO, Lee CM, Park YM (2004) Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-κB. Immunology 113: 203-211. 
• Kim JY, Paik JK, Kim OY, Park HW, Lee JH, Jang Y, Lee JH (2010) Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men. Atherosclerosis 215: 189-195.  
• Linnewiel K, Ernst H, Caris-Veyrat C, Ben-Dor A, Kampf A, Salman H, Danilenko M, Levy J, Sharoni Y (2009) Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system. Free Radic Biol Med 47: 659-667. 
• Markovitch D, Tyrrell RM, Tauler P, Frystyk J, Stokes K, Thompson D (2009) Lycopene supplementation (passata sauce) reduces apoptosis but does not affect oxidant-responsive heme oxygenase-1 in human lymphocytes. Nutrition 25: 668-675. 
• Neyestani TR, Shariatzadeh N, Gharavi A, Kalayi A, Khalaji N (2007) Physiological dose of lycopene suppressed oxidative stress and enhanced serum levels of immunoglobulin M in patients with Type 2 diabetes mellitus: a possible role in the prevention of long-term complications. J Endocrinol Invest 30: 833-838. 
• Palozza P, Serini S, Di Nicuolo F, Calviello G (2004) Modulation of Apoptotic Signalling by Carotenoids in Cancer Cells. Arch Biochem Biophys 430: 104-109. 
• Palozza P, Sheriff A, Serini S, Boninsegna A, Maggiano N, Ranelletti FO, Calviello G, Cittadini A (2005) Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1 pAKT and pBad. Apoptosis 10: 1445-1456. 
• Palozza P, Parrone N, Catalano A, Simone R (2010a) Tomato lycopene and inflammatory cascade: basic interactions and clinical implications. Curr Med Chem 17: 2547-2563. 
• Palozza P, Parrone N, Simone R, Catalano A (2010b) Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studies. Arch Biochem Biophys 504: 26-33. 
• Palozza P, Simone R, Catalano A, Boninsegna A, Böhm V, Fröhlich K, Mele MC, Monego G, Ranelletti FO (2010c) Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. J Nutr Biochem 21: 34-46.  
• Palozza P, Colangelo M, Simone R, Catalano A, Boninsegna A, Lanza P, Monego G, Ranelletti FO (2010d) Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis 31: 1813-1821. 
• Palozza P, Parrone N, Simone R, Catalano A (2011a) Role of lycopene in the control of ROS-mediated cell growth: implications in cancer prevention. Curr Med Chem 18: 1846-1860. 
• Palozza P, Simone R, Catalano A, Monego G, Barini A, Mele MC, Parrone N, Trombino S, Picci N, Ranelletti FO (2011b) Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. J Nutr Biochem 22: 259-268. 
• Palozza P, Simone R, Catalano A, Parrone N, Monego G, Ranelletti FO (2011c) Lycopene regulation of cholesterol synthesis and efflux in human macrophages J Nutr Biochem 22: 971-978.  
• Rafi MM, Yadav PN, Reyes M (2007) Lycopene inhibits LPS-induced proinflammatory mediator inducible nitric oxide synthase in mouse macrophage cells. J Food Sci 72: S069-S074. 
• Rao AV (2002) Lycopene, tomatoes, and the prevention of coronary heart disease. Exp Biol Med (Maywood) 227: 908-913. 
• Riso P, Visioli F, Grande S, Guarnieri S, Gardana C, Simonetti P, Porrini M (2006) Effect of a tomato-based drink on markers of inflammation, immunomodulation, and oxidative stress. J Agric Food Chem 54: 2563-2566. 
• Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin MA, Watson RE, Rhodes LE (2011) Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial Br J Dermatol 164: 154-162. 
• Sahin K, Tuzcu M, Sahin N, Ali S, Kucuk O (2010) Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene. Food Chem Toxicol 48: 2670-2674. 
• Sarkar FH, Li Y, Wang Z, Kong D (2009) Cellular signaling perturbation by natural products. Cell Signal 21: 1541-1547. 
• Schrek R, Bauerle PA (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-κB transcription factor and HIV-1. Trends Cell Biol 1: 39-42.
• Seo Y, Masamune A, Shimosegawa T, Kim H (2009) Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells jeong. Ann NY Acad Sci 1171: 570-575. 
• Talvas J, Caris-Veyrat C, Guy L, Rambeau M, Lyan B, Minet-Quinard R, Lobaccaro JM, Vasson MP, Georgé S, Mazur A, Rock E (2010) Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells. Am J Clin Nutr 91: 1716-1724.  
• Tang XY, Yang XD, Peng YF, Lin JH (2009) Protective effects of lycopene against H2O2-induced oxidative injury and apoptosis in human endothelial cells. Cardiovasc Drugs Ther 23: 439-448. 
• Torbergsen AC, Collins AR (2000) Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Eur J Nutr 39: 80-85. 
• Upritchard JE, Sutherland WH, Mann JI (2000) Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 23: 733-738. 
• Walrand S, Farges MC, Dehaese O, Cardinault N, Minet-Quinard R, Grolier P, Bouteloup-Demange C, Ribalta J, Winklhofer-Roob BM, Rock E, Vasson MP (2005) In vivo and in vitro evidences that carotenoids could modulate the neutrophil respiratory burst during dietary manipulation. Eur J Nutr 44: 114-120. 
• Watzl B, Bub A, Blockhaus M, Herbert BM, Lührmann PM, Neuhäuser-Berthold M, Rechkemmer G (2000) Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women. J Nutr 130: 1719-1723. 
• Xu A, Wu LJ, Santella RM, Hei TK (1999) Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells. Cancer Res 59: 5922-5926. 
• Zangar RC, Davydov DR, Verma S (2004) Mechanisms that regulate production of reactive oxygen species by cytochrome P450. Toxicol Appl Pharmacol 199: 316-331. 
• Zhang H, Kotake-Nara E, Ono H, Nagao A (2003) A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells. Free Radic Biol Med 35: 1653-1663. 
• Zhao X, Aldini G, Johnson EJ, Rasmussen H, Kraemer K, Woolf H, Musaeus N, Krinsky NI, Russell RM, Yeum KJ (2006) Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Am J Clin Nutr 83: 163-169.

Uwagi

PL

Rekord w opracowaniu.