Evidence of Fasciola spp. resistance to albendazole, triclabendazole and bromofenofos in water buffaloes (Bubalus bubalis)

• Autorzy: Venturina V.M. , Alejandro A.F. , Baltazar C.P. , Abes N.S. , Mingala C.N.
• Języki publikacji: EN

Abstrakty

EN

Fasciolosis caused by Fasciola spp. is considered the most important helminth infection of ruminants in tropical countries. Anthelmintic resistance has become a global concern. This study compared the efficacy of the commonly used anthelmintics, determined the toxicity level and any indication of resistance. Thirty two water buffaloes naturally-infected with Fasciola spp. were used to determine the efficacy of triclabendazole (TBZ), albendazole (ABZ), and bromofenofos (BRO) using Fecal Egg Count Reduction Test (FECRT). To test the toxicity of the drugs given, serum glutamic-pyruvic transaminase (SGPT) was evaluated before and within one week after treatment. One dose administration of ABZ registered an efficacy of 79.17%, 73.33% for TBZ and 70.83% for BRO. Efficacy in two dosetreatment group was 83.33% for both BRO and ABZ, and 90.00% for TBZ. Two dose-treatment was effective for TBZ (90%), ineffective for BRO and ABZ. SGPT levels were not significantly different between pre-treatment and posttreatment across all treatments. Giving one or two doses of anthelmintics, at one month interval, does not increase the efficacy of the three drugs tested. The study also implies that anthelmintic resistance may have developed in the animals.

Słowa kluczowe

EN

evidence; Fasciola; fasciolosis; resistance; albendazole; triclabendazole; bromofenofos; water buffalo; Bubalus bubalis

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2015
• Tom: 61
• Numer: 4
• Opis fizyczny: p.283–289,fig.,ref.

Twórcy

autor

Venturina V.M.

• College of Veterinary Science and Medicine, Central Luzon State University, Science City of Munoz 3120, Nueva Ecija, Philippines

autor

Alejandro A.F.

• College of Veterinary Science and Medicine, Central Luzon State University, Science City of Munoz 3120, Nueva Ecija, Philippines

autor

Baltazar C.P.

• Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Munoz 3120, Nueva Ecija, Philippines

autor

Abes N.S.

• Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Munoz 3120, Nueva Ecija, Philippines

autor

Mingala C.N.

• Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Munoz 3120, Nueva Ecija, Philippines
• Department of Animal Science, Affiliate Faculty, College of Agriculture, Central Luzon State University, Science City of Munoz 3120, Nueva Ecija, Philippines

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Identyfikatory

DOI

10.17420/ap6104.20