The role of dopamine transporter in attentional functions

• Autorzy: Cybulska-Klosowicz A.
• Języki publikacji: EN

Abstrakty

EN

Attentional functions are regulated by a dopaminergic (DA) system. Dopamine transporter (DAT), regulating DA neurotransmission, likely plays a role in controlling the influence of DA in cognitive processes. The aim of the study was to examine the role of DAT in attention. Mice with DAT gene genetically deleted (DAT+/- heterozygotes) were compared with the wild type (WT) mice in several tests of attention. Locomotor activity and non-selective attention were tested in a Làt-maze. Attentional set-shifting was tested in intradimensional shift (IDS) and in extradimensional shift (EDS) phases of the attentional set-shifting task (ASST). Associative and reversal learning were tested in a simple discrimination (SD), compound discrimination (CD) and reversal (Rev) phases of ASST task. Sustained attention was tested in an operant chamber. DAT level in the striatum of mice was compared using DAT immunohistochemistry. Neuronal activity during ASST was visualised with the egr-1 and egr-2 immunohistochemistry. The results obtained show that DAT+/- mice have significantly higher scores of locomotor activity in comparison with WT mice. DAT+/- mice do not differ in simple associative learning and non-selective attention scores when compared with WT mice. However, they are impaired in tests that tax executive control function of attention. The results suggest that normal DAT activity level is required for optimal attentional functioning. NSC Grant 2011/01/D/NZ4/04958.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.349

Twórcy

autor

Cybulska-Klosowicz A.

• Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland