Performance of a matching pursuit based classifier on vep: a potential parameter for assessment of the state of patients with disorders of consciousness

• Autorzy: Dovgialo M. , Chabuda A. , Duszyk A. , Pietrzak M. , Rozanski P. , Zieleniewska M. , Durka P.J.
• Języki publikacji: EN

Abstrakty

EN

INTRODUCTION: P300 event‑related potential reflects the brain response to external stimuli. Attention paid to one of many repeatedly presented stimuli can be detected from the relative strengths of the responses; if the subject actively counts the occurrences of one of the stimuli (target), specific waveform responsе, namely the P300 potential, may be observed, and it will be absent during the unattended (non‑target) stimuli. This difference can be used as an indicator of conscious information processing in unresponsive patients suffering from disorders of consciousness (DoC). However, P300 waveforms recorded from those patients may significantly differ from the classical shape known from healthy subjects. AIM(S): We test the possibility of replacing the classical indicators used for assessing the difference between responses to target and non-target stimuli by cross-validation of a classifier detecting responses, based upon multivariate matching pursuit (MMP) parameterization. METHOD(S): Visual P300 potentials were recorded in a standard paradigm from a group of healthy subjects and patients in different states of disorder of consciousness. MMP algorithm was used as parametrization, and based upon a subset of recorded data a classifier was trained to distinguish responses to target and non-target stimuli. RESULTS: Cross‑validation performance of the classifier measured as the area under corresponding ROC curves discriminates the healthy group from DoC patients, and in some cases correlates with the severity of DoC. CONCLUSIONS: Replacing estimation of the statistical significance of the average P300 amplitudes by the performance of MMP‑based classification assessed by cross‑validation allows for nonparametric detection of conscious responses in DoC patients, whose ERPs do not always exhibit the classical components. FINANCIAL SUPPORT: This research was supported by the Polish National Science Centre grant 2015/17/B/ ST7/03784.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: Suppl.1
• Opis fizyczny: p.64-65

Twórcy

autor

Dovgialo M.

• University of Warsaw, Faculty of Physics, Warsaw, Poland

autor

Chabuda A.

• University of Warsaw, Faculty of Physics, Warsaw, Poland

autor

Duszyk A.

• University of Warsaw, Faculty of Physics, Warsaw, Poland

autor

Pietrzak M.

• University of Warsaw, Faculty of Physics, Warsaw, Poland

autor

Rozanski P.

• University of Warsaw, Faculty of Physics, Warsaw, Poland

autor

Zieleniewska M.

• University of Warsaw, Faculty of Physics, Warsaw, Poland

autor

Durka P.J.

• University of Warsaw, Faculty of Physics, Warsaw, Poland