Ameliorative potentials of a combination of fenugreek and alpha-tocopherol on cadmium induced testicular toxicity: an ultrastructural study

• Autorzy: Hussein A.M. , Mustafa H.N. , Badawoud M.H.
• Języki publikacji: EN

Abstrakty

EN

Background: The current study aimed to elucidate the protective role of combined fenugreek and α-tocopherol against cadmium induced histopathological changes in the testes. Materials and methods: Thirty adult male albino rats divided into three equal groups 10 rats each. Group I is the control group. Group II received 5 mg/kg/ day cadmium chloride. Group III received 5 mg/kg/day cadmium chloride and 150 mg/kg/day fenugreek and 100 mg/kg/day of α-tocopherol. The treatment of all groups was done by oral gavage for 60 consecutive days. The testes were removed and subjected to histopathological and ultrastructure study. Results: Rats exposed to cadmium showed severe histopathological changes in the testicular spermatogenic series, many vacuoles and multinucleated giant cells. Treatment with fenugreek and α-tocopherol partially improved the morphological changes, reduced tissue damage and rebuilt of the spermatogonia layer. Conclusions: Fenugreek and α-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure. (Folia Morphol 2015; 74, 3: 325–334)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2015
• Tom: 74
• Numer: 3
• Opis fizyczny: p.325-334,fig.,ref.

Twórcy

autor

Hussein A.M.

• Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

autor

Mustafa H.N.

• Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

autor

Badawoud M.H.

• Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

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Identyfikatory

DOI

10.5603/FM.2015.0049