Synthesis of carotenoid-cysteine conjugates

• Autorzy: Zand A. , Agocs A. , Deli J. , Nagy V.
• Języki publikacji: EN

Abstrakty

EN

 Isozeaxanthin under acidic conditions forms an allylic cation which reacts readily with thiol nucleophiles. With N-acetylcysteine as a nucleophile the products obtained are carotenoid-cysteine conjugates in which the amino acid moiety is attached to the carotenoid via sulphur in position 4. The water solubility of the products can be increased by deprotection of the amino group. The antioxidant activity of the products were examined on human liver cells under conditions of hydrogen-peroxide induced oxidative stress.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 1
• Opis fizyczny: p.149-150,fig.,ref.

Twórcy

autor

Zand A.

• Department of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Pecs, Hungary

autor

Agocs A.

autor

Deli J.

autor

Nagy V.

Bibliografia

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• Nagy V, Agócs A, Turcsi E, Deli J (2010) Experiments on the synthesis of carotenoid glycosides. Tetrahedron Lett 51: 2020-2022.
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• Tapodi A, Debreceni B, Hantó K, Bognár Z, Wittmann I, Gallyas F, Várbíró G, Sümegi B (2005) Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose) polymerase-1 inhibition in oxidative stress. J Biol Chem 280: 35767-35775.

Uwagi

PL

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