Association between polymorphism in STAT5A gene and milk production traits in Chinese Holstein cattle

• Autorzy: Bao B. , Zhang C. , Fang X. , Zhang R. , Gu C. , Lei C. , Chen H.

Warianty tytułu

PL

Związek polimorfizmu genu STAT5A z cechami produkcji mlecznej chińskiego bydła holsztyńsko-fryzyjskiego

• Języki publikacji: EN

Abstrakty

EN

STAT5 is a key intracellular mediator of prolactin signaling and can activate transcription of milk proteins in response to prolactin. STAT5 genes are suggested to be candidate markers for milk protein yield and composition in dairy cattle. PCR-SSCP was applied to analyze the polymorphisms of two loci in STAT5A gene in 279 Chinese Holstein cattle. Genotype frequencies, allele frequencies and correlation coefficients between the polymorphic variants and milk production traits were estimated. Three genotypes were found at the two loci. At locus P1 the frequencies of genotypem AA/GG/AG were 0.240/0.147/0.613 and those of alleles A and G were 0.547 and 0.453, respectively. The A/G genotypes had significant effect on milk yield and milk protein content in lactations 1 and 2. At locus P2 the genotype frequencies of CC/TT/CT were 0.752/0.004/0.244 and C and T allele frequencies were 0.875 and 0.125, respectively. Different genotypes had remarkable effect on the milk protein content in lactation 2.

PL

Czynniki STAT5 są ważnymi wewnątrzkomórkowymi mediatorami działania hormonów a STAT5A pośredniczy w działaniu prolaktyny na transkrypcję genów białek mleka. Gen STAT5A jest rozważany jako potencjalny marker wydajności i składu mleka bydła. Zastosowano techniki PCR-SSCP do analizy polimorfizmu genu w dwóch loci genu STAT5A u 279 chińskich krów rasy holsztyńsko-fryzyjskiej.Wyliczono frekwencje genotypów i alleli oraz korelacje pomiędzy wariantami genu STAT5A i cechami produkcji mlecznej krów. Dla obu loci znaleziono trzy genotypy. W locus P1 frekwencja genotypów AA/GG/AG wyniosła odpowiednio 0.240/0.147/0.613 a frekwencja alleli A i G - 0.547 i 0.453. Wykazano, że genotypy A/G istotnie wpływały na wydajność mleczną i zawartość białka w mleku krów w pierwszej i drugiej laktacji. W locus P2 frekwencja genotypów CC/TT/CT wyniosła odpowiednio 0.752/0.004/0.244, a frekwencja alleli C i T - 0.875 i 0.125. Genotypy C/T miały istotny wpływ na zawartość białka w mleku w drugiej laktacji.

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2010
• Tom: 28
• Numer: 1
• Opis fizyczny: p.5-11,fig.,ref.

Twórcy

autor

Bao B.

• Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, Jiangsu,China

autor

Zhang C.

• Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, Jiangsu,China

autor

Fang X.

• Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, Jiangsu,China

autor

Zhang R.

• Shaanxi Key Laboratory of Biology for Agriculture, College of Animal Science and Technology, Northwest A and F University, Yangling 712100, Shaanxi, China

autor

Gu C.

• Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, Jiangsu,China

autor

Lei C.

• Shaanxi Key Laboratory of Biology for Agriculture, College of Animal Science and Technology, Northwest A and F University, Yangling 712100, Shaanxi, China

autor

Chen H.

• Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, Jiangsu,China

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