Terminalia chebula Retz. - an important medicinal plant

• Autorzy: Kolla J.N. , Kulkarni N.M. , Kura R.R. , Theepireddy S.K.R.

Warianty tytułu

PL

Terminalia chebula Retz. - ważna roślina lecznicza

• Języki publikacji: EN

Abstrakty

EN

Ayurveda, whispered to be the ancient practice of healthcare existed and contributes a holistic approach to health, healing and longevity. Terminalia chebula Retz. is a popular plant and widely spread all over southern Asia. T. chebula is a native plant of India and its dried fruit is extensively used in various types of home remedies. Dried fruit of T. chebula contains high quantities phenolic compounds that consist of ellagic acid, gallic acid and chebulic acid. The fruit extract of T. chebula is known to display different biological properties like anticancer, anti-inflammatory, antioxidant, anti-protozoal, antimicrobial, hepato and renal protective activities, and in the management of metabolic syndrome. The phenolic active compounds might play vital role in the influence of biological activity. Fruit extract of T. chebula is widely employed as an important ingredient in various ayurvedic preparations like ‘Triphala’. This formulation is beneficial as detoxifying agent of the colon, purgative in chronic constipation, aids in digestion and as a body rejuvenator. The fruit has great medicinal significance and conventionally applied for the management of various illness conditions, such as sore throat, high cough, asthma, ulcers, gout, heart burn, vomiting, diarrhea, dysentery, bleeding piles and bladder diseases. It is also utilized as mild laxative, antispasmodic and stomachic. Because of these enormous medicinal properties, T. chebula is commonly termed as ‘King of Medicine’ in Tibet and can be called as a ‘wonder herb’. In the present review, recent advances in medicinal properties of T. chebula are discussed.

PL

Medycyna ajurwedyjska jest znanym od dawna sposobem dbania o zdrowie stosującym holistyczne podejście do leczenia i przedłużenia życia. Terminalia chebula Retz. jest popularną rośliną szeroko rozpowszechnioną w południowej Azji. T. chebula pochodzi z Indii, a jej suszone owoce są powszechnie stosowane w wielu domowych środkach leczniczych. Suszone owoce T. chebula zawierają duże ilości związków fenolowych składających się z kwasu elagowego, galusowego i chebulowego. Wyciąg z owoców T. chebula wykazuje wiele właściwości biologicznych, takich jak przeciwnowotoworowe, przeciwzapalne, antyoksydacyjne, przeciwpierwotniakowe, przeciwdrobnoustrojowe, chroniące wątrobę i nerki, a także w leczeniu zespołu metabolicznego. Aktywne związki fenolowe mogą odgrywać ważną rolę, wpływając na aktywność biologiczną. Wyciąg z owoców T. chebula jest szeroko stosowany jako ważny składnik preparatów ajurwedyjskich, na przykład „Triphala”. Ta mieszanka pomaga w detoksykacji jelita grubego, działa przeczyszczająco w przewlekłych zaparciach, wspomaga trawienie i ma działanie odmładzające. Owoce są stosowane w leczeniu rozmaitych stanów chorobowych takich jak ból gardła, silny kaszel, astma, wrzody, dna moczanowa, zgaga, wymioty, biegunka, czerwonka, wylewy krwi do stawów i choroby pęcherza moczowego. Stosuje się je również jako łagodny środek przeczyszczający, rozluźniający i w chorobach żołądka. Dzięki tym wszechstronnym właściwościom leczniczym T. chebula bywa nazywana w Tybecie „królem medycyny” lub „cudowną rośliną”. W niniejszym przeglądzie omówiono ostatnie postępy w odkrywaniu właściwości leczniczych T. chebula.

Słowa kluczowe

EN

Terminalia chebula; medicinal plant; fruit; dried fruit; phytochemical; medicinal property

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2017
• Tom: 63
• Numer: 4
• Opis fizyczny: p.45-56,ref.

Twórcy

autor

Kolla J.N.

• Hetero Research Foundation, Plot No B80 and 81, A.P.I.E.Balanagar, Hyderabad-500018, Telangana, India

autor

Kulkarni N.M.

• Hetero Research Foundation, Plot No B80 and 81, A.P.I.E.Balanagar, Hyderabad-500018, Telangana, India

autor

Kura R.R.

• Hetero Research Foundation, Plot No B80 and 81, A.P.I.E.Balanagar, Hyderabad-500018, Telangana, India

autor

Theepireddy S.K.R.

• Hetero Research Foundation, Plot No B80 and 81, A.P.I.E.Balanagar, Hyderabad-500018, Telangana, India

Bibliografia

• 1. World Health Organization [WHO]. In vitro screening of traditional medicines for anti-HIV activity: memorandum from a WHO meeting. Bull World Health Organ 1989; 67:613-8.
• 2. Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Disc 2005; 4:206-20. doi: http://dx.doi.org/10.1038/nrd1657
• 3. Bone K. Clinical applications of Ayurvedic and Chinese herbs. Phytother Press 1996:137-41.
• 4. Bag A, Bhattacharyya SK, Chattopadhyay RR. The development of Terminalia chebula Retz. (Combretaceae) in clinical research. Asian Pac J Trop Biomed 2013; 3(3):244-52. doi: http://dx.doi.org/10.1016/S2221-1691(13)60059-3
• 5. Rathinamoorthy R, Thilagavathi G. Terminalia chebula – Review on pharmacological and biochemical studies. Int J Pharm Tech Res 2014; 6(1):97-116.
• 6. Saleem A, Husheem M, Harkonen P, Pihlaja K. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz. fruit. J Ethnopharmacol 2002; 81(3):327-36. doi: http://dx.doi.org/10.1016/S0378-8741(02)00099-5
• 7. Kim HG, Cho JH, Jeong EY, Lim JH, Lee SH, Lee HS. Growth inhibitory activity of active component from Terminalia chebula fruits against intestinal bacteria. J Food Prot 2006; 69(9):2205- 2209.
• 8. Lee HS, Jung SH, Yun BS, Lee KW. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxic 2007; 81(3):211-218. doi: http://dx.doi.org/10.1007/s00204-006-0139-4
• 9. Govt. of India. The Ayurvedic Pharmacopoeia of India. New Delhi: Government of India Ministry of Health and Family Welfare Department of Indian System of Medicine & Homoeopathy 2001:47.
• 10. Williamson I, Stewart TM, White MA, York-Crowe E. An information-processing perspective on body image. In: Cash T. F. & Pruzinsky T. (eds.) Body image: A handbook of theory, research, and clinical practice. New York. Guilford Press 2002:47-54.
• 11. Juang LJ, Sheu SJ, Lin TC. Determination of hydrolyzable tannins in the fruit of Terminalia chebula by high-performance liquid chromatography and capillary electrophoresis. J Sep Sci 2004; 27(9):718-24. doi: http://dx.doi.org/10.1002/jssc.200401741
• 12. Khare CP. Indian medicinal plants – an illustrated dictionary. 1st Indian Reprint. New Delhi 2007:717-8.
• 13. Jayaramkumar K. Effect of geographical variation on content of tannic acid, gallic acid, chebulinic acid, and ethyl gallate in Terminalia chebula fruits. Nat Prod 2006; 2(3-4):170-5.
• 14. Kumar A, Lakshman K, Jayaveera K, Satish K, Tripathi SM. Estimation of rutin and quercetin Terminalia chebula by HPLC. Int J Aesth Antiag Med 2009; 2(1):3.
• 15. Thakur M, Rana RC, Thakur S. Physiochemical evaluation of Terminalia chebula fruits. J Non Timber Forest Prod 2008; 15:37-42.
• 16. Tubtimdee C, Shotipruk A. Extraction of phenolics from Terminalia chebula Retz. with waterethanol and water-propylene glycol and sugaring-out concentration of extracts. Sep Puri Tech 2011; 77(3):339-46.
• 17. Rangsriwong P, Rangkadilok N, Satayavivad J, Goto M, Shotipruk A. Subcritical water extraction of polyphenolic compounds from Terminalia chebula Retz. fruits. Sep Puri Tech 2009; 66:51-6.
• 18. Muhammad S, Khan BA, Akhtar N, Mahmood T, Rasul A, Hussain I et al. The morphology, extractions, chemical constituents and uses of Terminalia chebula: A review. J Med Plants Res 2012; 6(33):4772-4775.
• 19. Yoganarasimhan SN. Medicinal plants of India. Bangalore 2000:541.
• 20. Mammen D, Bapat S, Sane R. An investigation to variation in constituents in the fruits of Terminalia chebula Retz. at different maturity stages. Int J Pharm Bio Sci 2012; 3(1):416-419.
• 21. Baliah TN, Astalakshmi A. Phytochemical analysis and antibacterial activity of extracts from Terminalia chebula Retz. Inter J Curr Micro and Appl Sci 2014; 3(3):992-999.
• 22. Majed F, Nafees S, Rashid S, Ali N, Hasan SK, Ali R, Shahid A, Sultana S. Terminalia chebula attenuates DMBA/croton oil-induced oxidative stress and inflammation in Swiss albino mouse. Skin Toxicol Int 2015; 22(1):21-9. doi: http://dx.doi.org/10.4103/0971-6580.172252
• 23. Eshwarappa RS, Ramachandra YL, Subaramaihha SR, Subbaiah SG, Austin RS, Dhananjaya BL. Antioxidant activities of leaf galls extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae). Acta Sci Pol Technol Aliment 2015; 14(2):97-105. doi: http://dx.doi.org/10.17306/J.AFS.2015.2.11
• 24. Ashwini R, Gajalakshmi S, Mythili S, Sathiavelu A. Terminalia chebula - A pharmacological review. J Pharm Res 2011; 4(9):2884-2887.
• 25. Sohni YR, Kaimal P, Bhatt RM. The antiamoebic effect of crude drug formulation of herbal extracts against Entamoeba histolytica in vitro and in vitvo. J Ethnopharmacol 1995; 45(1):43-52. doi: http://dx.doi.org/10.1016/0378-8741(94)01194-5
• 26. Bagavan A, Rahuman Al, Kamaraj C, Kaushik NK, Mohanakrishnan D, Sahal D. Antiplasmodial activity of botanical extracts against Plasmodium falciparum. Parasitol Res 2011; 108(5):1099-1109. doi: http://dx.doi.org/10.1007/s00436-010-2151-0
• 27. Joshi B, Hendrickx S, Magar LB, Parajuli N, Dorny P, Maes L. In vitro antileishmanial and antimalarial activity of selected plants of Nepal. J Intercult Ethnopharmacol 2016; 5(4):383-389. doi: http://dx.doi.org/10.5455/jice.20160728031236
• 28. Malckzadeh F, Ehsanifar H, Shahamat N, Levin M, Colwell RR. Antibacterial activity of black myrobalan (Terminalia chebula Retz.) against Helicobactor pyroli. Int J Antimicrob Agent 2001; 18(1):85-88. doi: http://dx.doi.org/10.1016/S0924-8579(01)00352-1
• 29. Khan KH, Jain SK. Regular intake of Terminalia chebula can reduce the risk of getting typhoid fever. Adv Biotech 2009; 8(9):10-15.
• 30. Sato Y, Oketani H, Singyouchi K, Ohtsubo T, Kihara M, Shibata H et al. Extraction and purification of effective antimicrobial constituents of Terminalia chebula Retz. against methicillin-resistant Staphylococcus aureus. Bull Pharm Bull 1997; 20(4):401-404. doi: http://dx.doi.org/10.1248/bpb.20.401
• 31. Kim HG, Cho JH, Jeong EY, Lim JH, Lee SH, Lee HS. Growth inhibitory activity of active component from Terminalia chebula fruits against intestinal bacteria. J Food Prot 2006; 69(9):2205-2209.
• 32. Bonjar GH. Antibacterial screening of plants used in Iranian folkloric medicine. Fitoterapia 2004; 75(2):231-235. doi: http://dx.doi.org/10.1016/j.fitote.2003.12.013
• 33. Aneja KR, Joshi R, Evaluation of antimicrobial properties of fruit extracts of Terminalia chebula against dental caries pathogens. Jundishapur J Microbiol 2009; 2(3):105-111.
• 34. Kannan P, Ramadevi SR, Hopper W. Antibacterial activity of Terminalia chebula fruit extract. Afr J Microbiol Res 2009; 3(4):180-184.
• 35. Nayak MR, Behera LK, Mishra PJ, Bhola N. Economics and yield performance of some short duration fruit and medicinal crops under agrisilvicultural system in rainfed uplands of Odisha. Ind J Appl Nat Sci 2014; 6(1):274-278.
• 36. Acharyya S, Sarkar P, Saha DR, Patra A, Ramamurthy T, Bag PK. Intracellular and membranedamaging activities of methyl gallate isolated from Terminalia chebula against multidrugresistant Shigella spp. J Med Microbiol 2015; 64(8):901-909. doi: http://dx.doi.org/10.1099/jmm.0.000107
• 37. Zearah SA. Antifungal and antibacterial activity of flavonoid extract from Terminalia chebula Retz. fruits. J Basrah Researches (Sciences) 2014; 40(1A):122-131.
• 38. Dutta BK, Rahman I, Das TK. Antifungal activity of Indian plant extracts. Mycoses 1998; 41(11-12):535-536.
• 39. Mehmood Z, Ahmad I, Mohammad F, Ahmad S. Indian medicinal plants: A potential source of anticandidal drugs. Pharm Biol 1999; 37(3):237-42. doi: http://dx.doi.org/10.1076/phbi.37.3.237.6296
• 40. Barazani VO, Sathiyomoorthy P, Shalev R, Vardy D, Golan GA. Screening of South-Indian medicinal plants for anti-fungal activity. Phyther Res 2003; 17(9):1123-1125. doi: http://dx.doi.org/10.1002/ptr.1399
• 41. Bonjar GH. Inhibition of Clotrimazole-resistant Candida albicans by plants used in Iranian folk loric medicine. Fitoterapia 2004; 75(1):74-76. doi: http://dx.doi.org/10.1016/j.fitote.2003.08.012
• 42. Gautam MK, Goel S, Ghatule RR, Singh A, Nath G, Goel RK. Curative effect of Terminalia chebula extract on acetic acid-induced experimental colitis: role of antioxidants, free radicals and acute inflammatory marker. Inflammopharmacology 2013; 21(5):377-383. doi: http://dx.doi.org/10.1007/s10787-012-0147-3
• 43. Badmaev V, Nowakowski M. Protection of epithelial cells against influenza A virus by plant-derived biological response modifier Ledretan-96. Phytother Res 2000; 44(4):245-249. doi: http://dx.doi.org/10.1002/1099-1573(200006)14:4<245::AIDPTR571>3.0.CO;2-O
• 44. Kurokawa M, Nagasaka K, Hirabayashi T, Uyama S, Sato H, Kageyama T, et al. Efficacy of traditional herbal medicines in combination with acyalovir against herpes simplex virus type1 infection in vitro and in vivo. Antiviral Res 1995; 27:19-37. doi: http://dx.doi.org/10.1016/0166-3542(94)00076-K
• 45. Ahmad I, Mehmood Z, Mohammad F. Screening of some Indian medicinal plants for their antimicrobial properties. J Ethnopharmacol 1998; 62: 183-193. doi: http://dx.doi.org/10.1016/S0378-8741(98)00055-5
• 46. Ma H, Zhao YD, Li K, Kang T. A new alternative to treat swine influenza A virus infection: extracts from Terminalia chebula Retz. Afr J Microbiol Res 2010; 4(6):497-499.
• 47. Lin LT, Chen TY, Chung CY, Noyce RS, Grindley TB, McCormick C, et al. Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit Herpes simplex virus 1 entry and cell-tocell spread. J Virol 2011; 85(9):4386-4398. doi: http://dx.doi.org/10.1128/JVI.01492-10
• 48. Ajala OS, Jukov A, Ma CM. Hepatitis C virus inhibitory hydrolysable tannins from the fruits of Terminalia chebula. Fitoterapia 2014; 99:117-123. doi: http://dx.doi.org/10.1016/j.fitote.2014.09.014
• 49. Oyuntsetseg N, Khasnatinov MA, Molor-Erdene P, Oyunbileg J, Liapunov AV, Danchinova GA et al. Evaluation of direct antiviral activity of the Deva-5 herb formulation and extracts of five Asian plants against influenza A virus H3N8. BMC Complement Altern Med 2014; 14:235. doi: http://dx.doi.org/10.1186/1472-6882-14-235
• 50. Yukawa TA, Kurokawa M, Sato S, Yoshida Y, Kageyamer S, Hasegawa T et al. Prophylactic treatment of cytomegalovirus infection with traditional herbs. Antiviral Res 1996; 32 (2):63-70. doi: http://dx.doi.org/10.1016/0166-3542(95)00978-7
• 51. Lee D, Boo K, Woo J, Duan F, Lee K, Kwon T et al. Antibacterial and anti-viral activities of extracts from Terminalia chebula barks. J Korean Soc Appl Biol Chem 2011; (2):295-8. doi: http://dx.doi.org/10.3839/jksabc.2011.046
• 52. Yadav IK, Jaiswal D, Singh HP, Mishra A, Jain DA. Anti- HIV drugs from natural sources. Pharma Res 2009; 1:93-109.
• 53. Das DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites 2012; 2(2):303-336. doi: http://dx.doi.org/10.3390/metabo2020303
• 54. Ahn MJ, Kim CY, Lee JS, Kim TG, Kim SH, Lee CK et al. Evaluation of anticancer potential of Terminalia chebula fruits against Ehrlich Ascites Carcinoma induced cancer in mice. JSIR 2013;2(3):549‐554.
• 55. Chinsembu K, Hedimbi M. Ethnomedicinal plants and other natural products with anti-HIV active compounds and their putative modes of action. Int J Biotech Mol Bio Res 2010; (6):74-91.
• 56. Singh J, Kumar A, Kumar V, Sethi JS. Medicinal plants with anti-HIV activity. Int J Nat Product Sci 2011; 1:1-8.
• 57. Mekkawy SE, Meselhy MR, Kusumoto IT, Kadota S, Hattori M, Namba T. Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. Chem Pharma Bulletin 1995; 43(4):641-648.
• 58. Kesharwani A, Polachira SK, Nair R, Agarwal A, Mishra NN, Gupta SK. Anti-HSV-2 activity of Terminalia chebula Retz. extract and its constituents, chebulagic and chebulinic acids. BMC Complement Altern Med 2017; 17(1):110. doi: http://dx.doi.org/10.1186/s12906-017-1620-8
• 59. Theepireddy SKR, Ramakrishna C, Vaikunta Rao L, Santosh V, Reddy KR, Mallikarjuna Rao D. Anti-HIV activity of Terminalia chebula crude extracts and gallic acid IJPT 2014; 6:6346-6354.
• 60. Saleem A, Husheem M, Harkonen P, Pihlaja K. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz. fruit. J Ethnopharmacol 2002; 81(3):327-336. doi: http://dx.doi.org/10.1016/S0378-8741(02)00099-5
• 61. Chang CL, Lin CS, Lai GH, Chen YH, Tuan WC, Hsu CM. Influence of Terminalia chebula extracts on the effect of PC12 cell growth. J Trad Med 2010; 21(1):23-30.
• 62. Ahuja R, Agrawal N, Mukerjee A. Evaluation of anticancer potential of Terminalia chebula fruits against Ehrlich Ascites Carcinoma induced cancer in mice. J Sci Innov Res 2013; 2(3):549-554.
• 63. Reddy DB, Reddy TC, Jyotsna G, Sharan S, Priya N, Lakshmipathi V et al. Chebulagic acid, a COXLOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line. J Ethnopharmacol 2009; 124(3):506-12. doi: http://dx.doi.org/10.1016/j.jep.2009.05.022
• 64. Achari C, Reddy GV, Reddy TC, Reddanna P. Chebulagic acid synergizes the cytotoxicity of doxorubicin in human hepatocellular carcinoma through COX-2 dependent modulation of MDR-1. Med Chem 2011; 7(5):432-442.
• 65. Wang P, Peng X, Wei ZE, Wei FY, Wang W, Ma WD et al. Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. Biochim Biophys Acta 2015; 1850:1751-1761. doi: http://dx.doi.org/10.1016/j.bbagen.2015.04.010
• 66. Ravi Shankara BE, Ramachandra YL, Rajan SS, Ganapathy PS, Yarla NS, Richard SA et al. Evaluating the anticancer potential of ethanolic gall extract of Terminalia chebula (Gaertn.) Retz. (Combretaceae). Pharmacognosy Res 2016; 8(3):209-212. doi: http://dx.doi.org/10.4103/0974-8490.182919
• 67. Wani K, Shah N, Prabhune A, Jadhav A, Ranjekar P, Kaul-Ghanekar R. Evaluating the anticancer activity and nanoparticulate nature of homeopathic preparations of Terminalia chebula. Homeopathy 2016; 105(4):318-326. doi: http://dx.doi.org/10.1016/j.homp.2016.02.004
• 68. Moeslinger T, Friedl R, Volf I, Brunner M, Koller E, Spieckermann PG. Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line. Can J Physiol Pharmacol 2000; 78(11):861-866.
• 69. Pratibha N, Saxena VS, Amit A, D’Souza P, Bagchi M, Bagchi D. Anti-inflammatory activities of Aller-7, a novel polyherbal formulation for allergic rhinitis. Int J Tissue React 2004; 26(1-2):43-51.
• 70. Nair V, Singh S, Gupta YK. Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models. J Pharm Pharmacol 2010; 62(12):1801-6. doi: http://dx.doi.org/10.1111/j.2042-7158.2010.01193.x
• 71. Yang MH, Ali Z, Khan IA, Khan SI. Anti-inflammatory activity of constituents isolated from Terminalia chebula. Nat Prod Com 2014; 9(7):965-968.
• 72. Zhao Y, Liu F, Liu Y, Zhou D, Dai Q, Liu S. Anti-arthritic effect of chebulanin on collagen-induced arthritis in mice. PLoS One 2015; 10(9):e0139052. doi: http://dx.doi.org/10.1371/journal.pone.0139052
• 73. Borgohain R, Lahon K, Das S, Gohain K. Evaluation of mechanism of anti-diabetic activity of Terminalia chebula on alloxan and adrenaline induced diabetic albino rats. Int J Pharm Bio Sci 2012; 3(3):256-266.
• 74. Senthilkumar GP, Subramanian SP. Biochemical studies on the effect of Terminalia chebula on the levels of glycoproteins in streptozotocin-induced experimental diabetes in rats. J Appl Biomed 2008; 6:105-115.
• 75. Lee DY, Yang H, Kim HW, Sung SH. New polyhydroxytriterpenoid derivatives from fruits of Terminalia chebula Retz. and their α-glucosidase and α-amylase inhibitory activity. Bioorg Med Chem Lett 2017; 27(1):34-39. doi: http://dx.doi.org/10.1016/j.bmcl.2016.11.039
• 76. Shyni GL, Kavitha S, Indu S, Arya AD, Anusree SS, Vineetha VP, et al. Chebulagic acid from Terminalia chebula enhances insulin mediated glucose uptake in 3T3-L1 adipocytes via PPARγ signaling pathway. Biofactors 2014; 40(6):646-657. doi: http://dx.doi.org/10.1002/biof.1193
• 77. Li K, Diao Y, Zhang H, Wang S, Zhang Z, Yu B et al. Tannin extracts from immature fruits of Terminalia chebula fructus Retz. promote cutaneous wound healing in rats. BMC Compl Alt Med 2011; 11:86. doi: http://dx.doi.org/10.1186/1472-6882-11-86
• 78. Singh D, Choi SM, Zo SM, Painuli RM, Kwon SW, Han SS. Effect of extracts of Terminalia chebula on proliferation of keratinocytes and fibroblasts cells: an alternative approach for wound healing. Evid Bas Compl Alt Med 2014; 701656. doi: http://dx.doi.org/10.1155/2014/ 701656
• 79. Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S. The effect of Terminalia chebula extract vs. silver sulfadiazine on burn wounds in rats. J Complement Integr Med 2015; 12(2):127-135. doi: http://dx.doi.org/10.1515/jcim-2014-0068
• 80. Tamhane MD, Thorate SP, Rege NN, Dahanukar SA. Effect of oral administration of Terminalia chebula on gastric emptying: an experimental study. J Postgrad Med 1997; 43(1):12-13.
• 81. Raju D, Ilango K, Chitra V, Ashish K. Evaluation of anti-ulcer actity of methanolic extract of Terminalia chebula fruits in experimental rats. Pharm Sci Res 2009; 1(3):101‐107.
• 82. Mishra V, Agrawal M, Onasanwo SA, Madhur G, Rastogi P, Pandey HP et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine 2013; 20(6):506-11. doi: http://dx.doi.org/10.1016/j.phymed.2013.01.002
• 83. Gupta PC. Biological and pharmacological properities of Terminalia chebula Retz. (Haritaki) – an overview. Int J Pharm Pharm Sci 2012; 4(3):62-68.
• 84. Mallik J, Das P, Karon B, Das S. A review on phytochemistry and pharmacological activity of Terminalia belerica. IJDFR 2012; 3(6):1-7.
• 85. Yakaew S, Itsarasook K, Ngoenkam J, Jessadayannamaetha A, Viyoch J, Ungsurungsie M. Ethanol extract of Terminalia chebula fruit protects against UVB-induced skin damage. Pharm Biol 2016; 54:2701-2707. doi: http://dx.doi.org/10.1080/13880209.2016.1179768
• 86. Sheng Z, Yan X, Zhang R, Ni H, Cui Y, Ge J et al. Assessment of the antidiarrhoeal properties of the aqueous extract and its soluble fractions of chebulae fructus (Terminalia chebula fruits). Pharm Biol 2016; 54(9):1847-1856. doi: http://dx.doi.org/10.3109/13880209.2015.1131993

Identyfikatory

DOI

10.1515/hepo-2017-0024