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2013 | 73 | Suppl.1 |

Tytuł artykułu

Brain state-related activity of septo -hippocampal neuronal network

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Biologically relevant synchronous discharges of assemblies of pyramidal neurons result from coordinated activity of oscillating neuronal networks. Cortical oscillating networks include different types of GABAergic interneuron, which are known to innervate different subdomains of pyramidal neurons. Interneurons contribute to different cortical rhythms by firing at different phases of field oscillations. The cortical network oscillators are embedded in larger oscillating networks comprising subcortical structures, such as the basal forebrain. An example of this kind of cortico-subcortical network is the hippocampus reciprocally connected with the medial septum belonging to the basal forebrain corticopetal system. The medial septum innervates the hippocampus through cholinergic, GABA-ergic and glutamatergic projections and receives a prominent GABA-ergic innervation from the hippocampus. Additionally, the GABA-ergic septo-hippocampal cells specifically target the GABA-ergic interneurons, implying a role in hippocampal rhythmogenesis. Extracellular recording and juxtacellular labelling of hippocampo-septal GABA-ergic neurons and septo-hippocampal neurons in vivo have provided insight into their functional properties, including firing patterns of identified neurons during different, brain state-dependent hippocampal oscillations.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

73

Numer

Opis fizyczny

p.14-15

Twórcy

  • Medical Research Council, Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford, U.K.

Bibliografia

Typ dokumentu

Bibliografia

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