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2019 | 78 | 2 |
Tytuł artykułu

Evaluation of PECAM-1 and p38 MAPK expressions in cerebellum tissue of rats treated with caffeic acid phenethyl ester: a biochemical and immunohistochemical study

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Background: This study aimed to investigate the antioxidative and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on damage caused to cerebellum tissue by diffuse traumatic head trauma via biochemical, histopathologic, and immuno-histochemical methods. Materials and methods: Male Sprague-Dawley (300–350 g) rats were subjected to traumatic brain injury with a weight-drop device (300 g/1 m weight-height impact). Twenty-four adult rats were randomly divided into three equal groups of 8, including a control group, traumatic brain injury (TBI) group, and TBI + CAPE treatment group (10 μmoL/kg/i.p.). Cerebellum tissue samples taken from anterior lobe from all rats were taken 7 days after traumatic injury and were subjected to biochemical and histopathological analysis, as well as immunohistochemical analysis for platelet endothelial cell adhesion molecule-1 (PECAM-1) and phosphate 38-mitogen-activated protein kinase (p38 MAPK). Results: In the TBI group, the granular layer had dilatation and haemorrhage in the capillary vessels and inflammatory cell infiltration around the periphery of the blood vessels. In the TBI + CAPE group, the small capillaries in the white matter were slightly dilated, there were no inflammatory cells, and dense chromatin/ granular cells were observed in the granular layer. Also in the TBI + CAPE group, the Purkinje cells of the ganglion cell layer had ovoid nuclei, were chromatin-rich, and their extensions protruded to the molecular layer. CAPE is thought to regulate inflammation, cell damage, and angiogenetic development by affecting the PECAM-1 and p38 MAPK proteins. Conclusions: These proteins are key modulators of endothelial integrity and neuroinflammation in vessels in response to endothelial damage as well as of the proinflammatory response in the cerebellum in response to traumatic damage. (Folia Morphol 2019; 78, 2: 221–229)
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EN
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-
Czasopismo
Rocznik
Tom
78
Numer
2
Opis fizyczny
p.221–229,fig.,ref.
Twórcy
autor
  • Department of Neurosurgery, University of Health Sciences, Gazi Yasargil Education and Research Hospital, Diyarbakır, Turkey
autor
  • Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey
Bibliografia
  • 1. Aebi HE. Catalase. In: Bergmeyer HU (eds). Methods of enzymatic analysis. 3rd edn. Verlag Chemie, Germany 1983: 273–286.
  • 2. Arumugam S, Girish Subbiah K, Kemparaju K, et al. Neutrophil extracellular traps in acrolein promoted hepatic ischemia reperfusion injury: Therapeutic potential of NOX2 and p38MAPK inhibitors. J Cell Physiol. 2018; 233(4): 3244–3261, doi: 10.1002/jcp.26167, indexed in Pubmed: 28884828.
  • 3. Ayla Ş, Tunalı G, Bilgiç BE, et al. Antioxidant activity of CAPE (caffeic acid phenethyl ester) in vitro can protect human sperm deoxyribonucleic acid from oxidative damage. Acta Histochem. 2018; 120(2): 117–121, doi: 10.1016/j.acthis.2018.01.001, indexed in Pubmed: 29325972.
  • 4. Barateiro A, Afonso V, Santos G, et al. S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis. Mol Neurobiol. 2016; 53(6): 3976–3991, doi: 10.1007/s12035-015-9336-6, indexed in Pubmed: 26184632.
  • 5. Caput D, Beutler B, Hartog K, et al. Identification of a common nucleotide sequence in the 3’-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A. 1986; 83(6): 1670–1674, indexed in Pubmed: 2419912.
  • 6. Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev. 2011; 75(1): 50–83, doi: 10.1128/MMBR.00031-10, indexed in Pubmed: 21372320.
  • 7. Carlos TM, Clark RS, Franicola-Higgins D, et al. Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats. J Leukoc Biol. 1997; 61(3): 279–285, indexed in Pubmed: 9060450.
  • 8. Chen J, Leskov IL, Yurdagul A, et al. Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-kB signaling and inflammation. Sci Signal. 2015; 8(365): ra20, doi: 10.1126/scisignal.2005648, indexed in Pubmed: 25714462.
  • 9. Chen Z, Tzima E. PECAM-1 is necessary for flow-induced vascular remodeling. Arterioscler Thromb Vasc Biol. 2009; 29(7): 1067–1073, doi: 10.1161/ATVBAHA.109.186692, indexed in Pubmed: 19390054.
  • 10. Choi JH, Roh KH, Oh H, et al. Caffeic acid phenethyl ester lessens disease symptoms in an experimental autoimmune uveoretinitis mouse model. Exp Eye Res. 2015; 134: 53–62, doi: 10.1016/j.exer.2015.03.014, indexed in Pubmed: 25795054.
  • 11. Coso OA, Chiariello M, Yu JC, et al. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell. 1995; 81(7): 1137–1146, indexed in Pubmed: 7600581.
  • 12. Deddens LH, van Tilborg GAF, van der Toorn A, et al. PECAM1-targeted micron-sized particles of iron oxide as MRI contrast agent for detection of vascular remodeling after cerebral ischemia. Contrast Media Mol Imaging. 2013; 8(5): 393–401, doi: 10.1002/cmmi.1536, indexed in Pubmed: 23740809.
  • 13. Demeule M, Labelle M, Régina A, et al. Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms. Biochem Biophys Res Commun. 2001; 281(3): 827–834, doi: 10.1006/bbrc.2001.4312, indexed in Pubmed: 11237734.
  • 14. Draper HH, Hadley M. Malondialdehyde determination as index of lipid Peroxidation. Methods Enzymol. 1990: 421–431, doi: 10.1016/0076-6879(90)86135-i.
  • 15. Duan S, Shao G, Yu L, et al. Angiogenesis contributes to the neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. Int J Neurosci. 2015; 125(8): 625–634, doi: 10.3109/00207454.2014.956101, indexed in Pubmed: 25171223.
  • 16. Fukuda K, Aihara N, Sagar SM, et al. Purkinje cell vulnerability to mild traumatic brain injury. J Neurotrauma. 1996; 13(5): 255–266, doi: 10.1089/neu.1996.13.255, indexed in Pubmed: 8797175.
  • 17. Gahmberg CG, Tolvanen M, Kotovuori P. Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands. Eur J Biochem. 1997; 245(2): 215–232, indexed in Pubmed: 9151947.
  • 18. Greenwood J, Etienne-Manneville S, Adamson P, et al. Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier. Vascul Pharmacol. 2002; 38(6): 315–322, indexed in Pubmed: 12529926.
  • 19. Gyoneva S, Ransohoff RM. Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell-cell communication by chemokines. Trends Pharmacol Sci. 2015; 36(7): 471–480, doi: 10.1016/j.tips.2015.04.003, indexed in Pubmed: 25979813.
  • 20. Haines JD, Fragoso G, Hossain S, et al. p38 Mitogen-activated protein kinase regulates myelination. J Mol Neurosci. 2008; 35(1): 23–33, doi: 10.1007/s12031-007-9011-0, indexed in Pubmed: 17994198.
  • 21. Hu M, Zhang Y, Feng J, et al. Uterine progesterone signaling is a target for metformin therapy in PCOS-like rats. J Endocrinol. 2018; 237(2): 123–137, doi: 10.1530/JOE-18-0086, indexed in Pubmed: 29535146.
  • 22. Huang C, Cao Z, Ma J, et al. AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells. Mol Carcinog. 2018; 57(10): 1300–1310, doi: 10.1002/mc.22844, indexed in Pubmed: 29846015.
  • 23. Hwang InK, Kim DW, Yoo KY, et al. Ischemia-induced changes of platelet endothelial cell adhesion molecule-1 in the hippocampal CA1 region in gerbils. Brain Res. 2005; 1048(1-2): 251–257, doi: 10.1016/j.brainres.2005.04.049, indexed in Pubmed: 15913570.
  • 24. Kaminska B, Gozdz A, Zawadzka M, et al. MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target. Anat Rec (Hoboken). 2009; 292(12): 1902–1913, doi: 10.1002/ar.21047, indexed in Pubmed: 19943344.
  • 25. Kaur C, Sivakumar V, Zou Z, et al. Microglia-derived proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta induce Purkinje neuronal apoptosis via their receptors in hypoxic neonatal rat brain. Brain Struct Funct. 2014; 219(1): 151–170, doi: 10.1007/s00429-012-0491-5, indexed in Pubmed: 23262920.
  • 26. Kerman M, Kanter M, Coşkun KK, et al. Neuroprotective effects of caffeic acid phenethyl ester on experimental traumatic brain injury in rats. J Mol Histol. 2012; 43(1): 49–57, doi: 10.1007/s10735-011-9376-9, indexed in Pubmed: 22124729.
  • 27. Kyosseva SV. Mitogen-activated protein kinase signaling. Int Rev Neurobiol. 2004; 59: 201–220, doi: 10.1016/S0074-7742(04)59008-6, indexed in Pubmed: 15006489.
  • 28. Lavoie JN, L’Allemain G, Brunet A, et al. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem. 1996; 271(34): 20608–20616, indexed in Pubmed: 8702807.
  • 29. Lertkiatmongkol P, Liao D, Mei H, et al. Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol. 2016; 23(3): 253–259, doi: 10.1097/MOH.0000000000000239, indexed in Pubmed: 27055047.
  • 30. Mandyam CD, Villalpando EG, Steiner NL, et al. Platelet endothelial cell adhesion molecule-1 and oligodendrogenesis: significance in alcohol use disorders. Brain Sci. 2017; 7(10), doi: 10.3390/brainsci7100131, indexed in Pubmed: 29035306.
  • 31. Mao LM, Wang JQ. Synaptically localized mitogen-activated protein kinases: local substrates and regulation. Mol Neurobiol. 2016; 53(9): 6309–6315, doi: 10.1007/s12035-015-9535-1, indexed in Pubmed: 26567109.
  • 32. Marmarou A, Foda MA, van den Brink W, et al. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg. 1994; 80(2): 291–300, doi: 10.3171/jns.1994.80.2.0291, indexed in Pubmed: 8283269.
  • 33. Minden A, Lin A, Claret FX, et al. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell. 1995; 81(7): 1147–1157, indexed in Pubmed: 7600582.
  • 34. Murohara T, Delyani JA, Albelda SM, et al. Blockade of platelet endothelial cell adhesion molecule-1 protects against myocardial ischemia and reperfusion injury in cats. J Immunol. 1996; 156(9): 3550–3557, indexed in Pubmed: 8617985.
  • 35. Nguyen V, Sabeur K, Maltepe E, et al. Sonic hedgehog agonist protects against complex neonatal cerebellar injury. Cerebellum. 2018; 17(2): 213–227, doi: 10.1007/s12311-017-0895-0, indexed in Pubmed: 29134361.
  • 36. Pabón MM, Acosta S, Guedes VA, et al. Brain region-specific histopathological effects of varying trajectories of controlled cortical impact injury model of traumatic brain injury. CNS Neurosci Ther. 2016; 22(3): 200–211, doi: 10.1111/cns.12485, indexed in Pubmed: 26775604.
  • 37. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70(1): 158–169, indexed in Pubmed: 6066618.
  • 38. Potts MB, Adwanikar H, Noble-Haeusslein LJ. Models of traumatic cerebellar injury. Cerebellum. 2009; 8(3): 211–221, doi: 10.1007/s12311-009-0114-8, indexed in Pubmed: 19495901.
  • 39. Privratsky JR, Newman PJ. PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res. 2014; 355(3): 607–619, doi: 10.1007/s00441-013-1779-3, indexed in Pubmed: 24435645.
  • 40. Rose BA, Yokota T, Chintalgattu V, et al. Cardiac myocyte p38a kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart. J Biol Chem. 2017; 292(31): 12787–12800, doi: 10.1074/jbc.M117.784553, indexed in Pubmed: 28637870.
  • 41. Rosenblum WI, Murata S, Nelson GH, et al. Anti-CD31 delays platelet adhesion/aggregation at sites of endothelial injury in mouse cerebral arterioles. Am J Pathol. 1994; 145(1): 33–36, indexed in Pubmed: 8030753.
  • 42. Roy AR, Delgado-Olguin P. Visualizing the vascular network in the mouse embryo and yolk sac. Methods Mol Biol. 2018; 1752: 11–16, doi: 10.1007/978-1-4939-7714-7_2, indexed in Pubmed: 29564758.
  • 43. Rubinfeld H, Seger R. The ERK cascade as a prototype of MAPK signaling pathways. Methods Mol Biol. 2004; 250: 1–28, doi: 10.1385/1-59259-671-1:1, indexed in Pubmed: 14755077.
  • 44. Sahu V, Nigam L, Agnihotri V, et al. Diagnostic significance of p38 isoforms (p38a, p38b, p38g, p38d) in head and neck squamous cell carcinoma: comparative serum level evaluation and design of novel peptide inhibitor targeting the same. Cancer Res Treat. 2019; 51(1): 313–325, doi: 10.4143/crt.2018.105, indexed in Pubmed: 29747487.
  • 45. Sari E, Bakar B, Sarkarati B, et al. Effectiveness of dimethylsulfoxide on the survival and volume preservation of autologous fat graft tissue: a preliminary study. Aesthet Surg J. 2016; 36(2): NP58–NP67, doi: 10.1093/asj/sjv119, indexed in Pubmed: 26242854.
  • 46. Seo TB, Kim BK, Ko IG, et al. Effect of treadmill exercise on Purkinje cell loss and astrocytic reaction in the cerebellum after traumatic brain injury. Neurosci Lett. 2010; 481(3): 178–182, doi: 10.1016/j.neulet.2010.06.087, indexed in Pubmed: 20603186.
  • 47. Springer T. Adhesion receptors of the immune system. Nature. 1990; 346(6283): 425–434, doi: 10.1038/346425a0.
  • 48. Sun L, Zou LX, Wang J, et al. Mucin 4 gene silencing reduces oxidative stress and calcium oxalate crystal formation in renal tubular epithelial cells through the extracellular signal-regulated kinase signaling pathway in nephrolithiasis rat model. Kidney Blood Press Res. 2018; 43(3): 820–835, doi: 10.1159/000490136, indexed in Pubmed: 29843125.
  • 49. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988; 34(3): 497–500, indexed in Pubmed: 3349599.
  • 50. Tan J, Liu D, Lv X, et al. MAPK mediates inflammatory response and cell death in rat pulmonary microvascular endothelial cells in an ischemia-reperfusion model of lung transplantation. J Heart Lung Transplant. 2013; 32(8): 823–831, doi: 10.1016/j.healun.2013.05.005, indexed in Pubmed: 23747218.
  • 51. Vaporciyan AA, DeLisser HM, Yan HC, et al. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science. 1993; 262(5139): 1580–1582, indexed in Pubmed: 8248808.
  • 52. Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004; 23(16): 2838–2849, doi: 10.1038/sj.onc.1207556, indexed in Pubmed: 15077147.
  • 53. Waskiewicz AJ, Cooper JA. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol. 1995; 7(6): 798–805, indexed in Pubmed: 8608010.
  • 54. Winzen R, Kracht M, Ritter B, et al. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AUrich region-targeted mechanism. EMBO J. 1999; 18(18): 4969–4980, doi: 10.1093/emboj/18.18.4969, indexed in Pubmed: 10487749.
  • 55. Wolters TL, Netea MG, Hermus AR, et al. IGF1 potentiates the pro-inflammatory response in human peripheral blood mononuclear cells via MAPK. J Mol Endocrinol. 2017; 59(2): 129–139, doi: 10.1530/JME-17-0062, indexed in Pubmed: 28611056.
  • 56. Wu N, Kurosu T, Oshikawa G, et al. PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells. Int J Oncol. 2013; 42(2): 419–428, doi: 10.3892/ijo.2012.1729, indexed in Pubmed: 23233201.
  • 57. Xia Z, Dickens M, Raingeaud J, et al. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 1995; 270(5240): 1326–1331, indexed in Pubmed: 7481820.
  • 58. Xiao H, Liu X, Wang Y, et al. Angiotensin(17) prevents lipopolysaccharideinduced hepatocellular inflammatory response by inhibiting the p38MAPK/AP1 signaling pathway. Mol Med Rep. 2018; 17(4): 5492–5497, doi: 10.3892/mmr.2018.8527, indexed in Pubmed: 29393446.
  • 59. Xie Y, Muller WA. Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1. Proc Natl Acad Sci U S A. 1993; 90(12): 5569–5573, indexed in Pubmed: 8516303.
  • 60. Yang G, Li T, Xu J, et al. Mitogen-activated protein kinases regulate vascular reactivity after hemorrhagic shock through myosin light chain phosphorylation pathway. J Trauma Acute Care Surg. 2013; 74(4): 1033–1043, doi: 10.1097/TA.0b013e31828586a2, indexed in Pubmed: 23511142.
  • 61. Yang SH, Sharrocks AD, Whitmarsh AJ. Transcriptional regulation by the MAP kinase signaling cascades. Gene. 2003; 320: 3–21, indexed in Pubmed: 14597384.
  • 62. Zhang J, Zhao D, Na N, et al. Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-kB pathway in ischemia/reperfusion injury after renal transplantation. Int J Mol Med. 2018; 41(1): 25–32, doi: 10.3892/ijmm.2017.3204, indexed in Pubmed: 29115389.
  • 63. Zhang X, Liu J, Zhang P, et al. Silibinin induces G1 arrest, apoptosis and JNK/SAPK upregulation in SW1990 human pancreatic cancer cells. Oncol Lett. 2018; 15(6): 9868–9876, doi: 10.3892/ol.2018.8541, indexed in Pubmed: 29805688.
  • 64. Zhang YY, Kong LQ, Zhu XD, et al. CD31 regulates metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway. Cancer Lett. 2018; 429: 29–40, doi: 10.1016/j.canlet.2018.05.004, indexed in Pubmed: 29746931.
  • 65. Zhu J, Ji Y, Yu Y, et al. Knockdown of serine/threonine protein phosphatase 5 enhances gemcitabine sensitivity by promoting apoptosis in pancreatic cancer cells . Oncol Lett. 2018; 15(6): 8761–8769, doi: 10.3892/ol.2018.8363, indexed in Pubmed: 29805615.
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