Inulin supplementation in rat model of pouchitis

• Autorzy: Drzymala-Czyz S. , Banasiewicz T. , Tubacka M. , Majewski P. , Biczysko M. , Koscinski T. , Drews M. , Walkowiak J.
• Języki publikacji: EN

Abstrakty

EN

Available data indicates potential effectiveness of prebiotic therapy in alleviating inflammation and prolonging the remission in inflammatory bowel disease. Documented successes of such therapies were the basis for this study. So far, there is no data related to the effectiveness of inulin application in symptomatic or severe pouchitis in humans or in animal model. The aim of the study was to determine the effect of inulin supplementation on the expression of intestinal inflammation and feeding efficiency in rats with induced pouchitis. Twenty-four Wistar rats were operated. After induction of pouchitis animals were randomly divided into control and supplementation groups receiving, respectively, semi-synthetic diet with or without inulin (in a lower (LD) or higher (HD) dose: 2.5 % or 5 % of total dietary content of mass) for a period of 6 weeks. Selected nutritional parameters were assessed throughout the study. Histopathological and immunohistochemical analysis of pouch mucosa specimens was also performed. The energy intake, weight gain, feeding efficiency, quality of stools were comparable in all studied groups. The intensity of inflammation (Moskovitz scale) and adaptive changes (Laumonier scale) did not differ between compared groups. The tissue expression of pro- and anti-inflammatory interleukins (IL-1α, IL-6, IL-10 and IL-12) was not different either. Inulin supplementation does not improve the quality of stools or the expression of intestinal inflammation in rats with induced pouchitis. It has no impact on the intensity of pouch adaptation or on feeding efficiency.

Słowa kluczowe

EN

inulin supplementation; rat model; pouchitis; restorative proctocolectomy; proctocolectomy; inflammatory bowel disease; high dose group; low dose group; ulcerative colitis

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2011
• Tom: 58
• Numer: 3
• Opis fizyczny: p.381-384,ref.

Twórcy

autor

Drzymala-Czyz S.

• Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland

autor

Banasiewicz T.

autor

Tubacka M.

autor

Majewski P.

autor

Biczysko M.

autor

Koscinski T.

autor

Drews M.

autor

Walkowiak J.

Bibliografia

• Badiali D, Corazziari E, Habib FI, Tomei E, Bausano G, Magrini P, Anzini F, Torsowi A (1995) Effect of wheat bran in treatment of chronic nonorganic constipation. A double-blind controlled trial. Dig Dis Sci 40: 349-356. 
• Bulois P, Tremaine WJ, Maunoury V, Gambiez L, Hafraoui S, Leteurtre L, Cortot A, Sandborn WJ, Colombel JF, Desreumaux P (2000) Pouchitis is associated with mucosal imbalance between interleukin-8 and interleukin-10. Inflamm Bowel Dis 6: 157-164. 
• Ferrante M, Declerck S, De Hertogh G, Van Assche G, Geboes K, Rutgeerts P, Penninckx F, Vermeire S, D'Hoore A (2008) Outcome after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. Inflamm Bowel Dis 14: 20-28. 
• Gionchetti P, Campieri M, Belluzzi A, Bertinelli E, Ferretti M, Brignola C, Poggioli G, Miglioli M, Barbara L (1994) Mucosal concentrations of interleukin-1 beta, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in pelvic ileal pouches. Dig Dis Sci 39: 1525-1531. 
• Hoda KM, Collins JF, Knigge KL, Deveney KE (2008) Predictors of pouchitis after ileal pouch-anal anastomosis: a retrospective review. Dis Colon Rectum 51: 554-560. 
• Hoentjen F, Welling GW, Harmsen HJ, Zhang X, Snart J, Tannock GW, Lien K, Churchill TA, Lupicki M, Dieleman LA (2005) Reduction of colitis by prebiotics in HLA-B27transgenic rats is associated with microflora changes and immunomodulation. Inflamm Bowel Dis 11: 977-985. 
• Hosono A, Ozawa A, Kato R, Ohnishi Y, Nakanishi Y, Kimura T, Nakamura R (2003) Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by murine Peyer's patch cells. Biosci Biotechnol Biochem 67: 758-764. 
• Józefiak D, Krejpcio Z, Trojanowska K, Wójciak R, Tubacka M, Śmigiel-Papińska D, Rutkowski A (2005) Effect dietary inulin on microbial ecosystem and concentrations of volatile fatty acids in rat's caecum. J Anim Feed Sci 14: 171-178.
• Lara-Villoslada F, de Haro O, Camuesco D, Comalada M, Velasco J, Zarzuelo A, Xaus J, Galvez H (2006) Short-chain fructooligosaccharides, in spite of being fermented in theupper part of the large intestine, have anti-inflammatory activity in the TNBS model of colitis. Eur J Nutr 45: 418-425. 
• Leal RF, Coy CS, Ayrizono ML, Fagundes JJ, Milanski M, Saad MJ, Velloso LA, Góes JR (2008) Differential expression of pro-inflammatory cytokines and a pro-apoptotic protein in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis. Tech Coloproctol 12: 33-38. 
• Leenen CH, Dieleman LA (2007) Inulin and oligofructose in chronic inflammatory bowel disease. J Nutr 137: 2572-2575. 
• Lichtman SN, Wang J, Hummel B, Lacey S, Sartor RB (1998) A rat model of ileal pouch-rectal anastomosis. Inflamm Bowel Dis 4: 187-195. 
• Lindsay JO, Whelan K, Stagg AJ, Gobin P, Al-Hassi HO, Rayment N, Kamm MA, Knight SC, Forbes A (2006) Clinical, microbiological, and immunological effects of fructooligosaccharide in patients with Crohn's disease. Gut 55: 348-355. 
• Macfarlane S, Macfarlane GT, Cummings JH (2006) Review article: prebiotics in the gastrointestinal tract. Aliment Pharmacol Ther 24: 701-714. 
• Nagle RB, Clark VA, McDaniel KM, Davis JR (1983) Immunohistochemical demonstration of keratins in human ovarian neoplasms. A comparison of methods. J Histochem Cytochem 31: 1010-1014. 
• Navaneethan U, Shen B (2009) Laboratory tests for patients with ileal pouch-anal anastomosis: clinical utility in predicting, diagnosing, and monitoring pouch disorders. Am J Gastroenterol 104: 2606-2615. 
• Novak J, Katz JA (2006) Probiotics and prebiotics for gastrointestinal infections. Curr Infect Dis Rep 8: 103-109. 
• Patel RT, Bain I, Youngs D, Keighley MR (1995) Cytokine production in pouchitis is similar to that in ulcerative colitis. Dis Colon Rectum 38: 831-837. 
• Pardi DS, Sandborn WJ (2006) Systematic review: the management of pouchitis. Aliment Pharmacol Ther 23: 1087-1096. 
• Sandborn WJ, Tremaine WJ, Batts KP, Pemberton JH, Phillips SF (1994) Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index. Mayo Clin Proc 69: 409-415. 
• Schmidt C, Häuser W, Giese T, Stallmach A (2007) Irritable pouch syndrome is associated with depressiveness and can be differentiated from pouchitis by quantification of mucosal levels of proinflammatory gene transcripts. Inflamm Bowel Dis 13: 1502-1508. 
• Shebani KO, Stucchi AF, Fruin B, McClung JP, Gee D, Beer ER, LaMorte WW, Becker JM (2002) Pouchitis in a rat model of ileal J pouch-anal anastomosis. Inflamm Bowel Dis 8: 23-34. 
• Welters CF, Heineman E, Thunnissen FB, van den Bogaard AE, Soeters PB, Baeten CG (2002) Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis. Dis Colon Rectum 45: 621-627.