Hippocampal interleukin-1beta in the juvenile and middle-aged rat: Response to chronic forced swim or high-light open-field stress stimulation

• Autorzy: Badowska-Szalewska E. , Ludkiewicz B. , Sidor-Kaczmarek J. , Lietzau G. , Spodnik J. H. , Swietlik D. , Domaradzka-Pytel B. , Morys J.
• Języki publikacji: EN

Abstrakty

EN

It is postulated that stress differentially affects interleukin-ip (IL-ip) during ontogenetic life. This study examined the influence of chronic exposure to forced swim (FS) stress or high-light open-field (HL-OF) stress on interleukin-ip (IL-ip). The total level of IL-ip protein was assessed by Western blot analysis of hippocampal extracts. Double immunofluorescence staining was used to reveal the percentage of IL-ip/NeuN (NeuN - neuronal marker) cells in the CA1, CA3 and dentate gyrus (DG) hippocampal subfields. Juvenile (P28; P - postnatal day) and middle-aged (P360) rats were used in the experiment. The research showed no significant differences in IL-ip protein levels between P28 and P360 non-stress rats. However, a substantial increase in the percentage of IL-ip-ir neurons in the CAi, CA3 and DG in P360 rats was observed. Chronic FS had no significant influence on IL-ip expression in the hippocampus or on the percentage of IL-ip-ir neurons in CAi, CA3 and DG hippocampal subfields in either age group. During HL-OF, the IL-ip level was significantly increased in the hippocampus of P28 and P360 rats, whereas a marked increase in the percentage of IL-ip-ir neurons in the CAi, CA3 and DG hippocampal areas occurred only in P360 animals. These results indicate that chronic HL-OF stimulation was the factor inducing changes in the IL-ip protein levels in P28 and P360 rats and in the percentage of IL-ip/NeuN-ir cells in the hippocampus of P360 animals.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: 3
• Opis fizyczny: p.364-378,fig.,ref.

Twórcy

autor

Badowska-Szalewska E.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Ludkiewicz B.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Sidor-Kaczmarek J.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Lietzau G.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Spodnik J. H.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Swietlik D.

• Faculty of Medical Informatics and Biostatistics, Medical University of Gdansk, Gdansk, Poland

autor

Domaradzka-Pytel B.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

autor

Morys J.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland

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