Presence of specific antibodies and proviral DNA of small ruminant lentiviruses in lambs in their first weeks of life

• Autorzy: Olech M. , Kubis P. , Lipecka C. , Junkuszew A. , Gruszecki T. M. , Kuzmak J.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to investigate the presence of proviral DNA and colostral antibodies in lambs born to and fed by ewes infected with small ruminant lentiviruses (SRLV). It was demonstrated that all 20 lambs tested 24 h after colostrum ingestion were serologically positive with high antibody titres. These gradually decreased with time, and at week 12 all lambs were seronegative. Twenty percent of lambs tested at the 2nd week postpartum were provirus positive by qPCR as a result of consumption of infected colostrum or in utero infection. When tested at three months of life, 95% of the lambs were provirus positive, probably as a result of horizontal transmission of the virus. Since these animals could play an important role in the early propagation of SRLV to susceptible herdmates, early removal of provirus-positive animals could help to prevent new infections.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2014
• Tom: 58
• Numer: 4
• Opis fizyczny: p.507-511,fig.,ref.

Twórcy

autor

Olech M.

• Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Kubis P.

• Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Lipecka C.

• Department of Small Ruminants Breeding and Agriculture Advisor, University of Life Sciences in Lublin, 20-950 Lublin, Poland

autor

Junkuszew A.

• Department of Small Ruminants Breeding and Agriculture Advisor, University of Life Sciences in Lublin, 20-950 Lublin, Poland

autor

Gruszecki T. M.

• Department of Small Ruminants Breeding and Agriculture Advisor, University of Life Sciences in Lublin, 20-950 Lublin, Poland

autor

Kuzmak J.

• Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland

Bibliografia

• 1. Alvarez V., Arranz J., Daltabuit-Test M., Leginagoikoa I., Juste R.A., Amorena B., de Andrés D., Luján_L.L., Badiola J.J., Berriatua E.: Relative contribution of colostrum from Maedi- Visna virus (MVV) infected ewes to MVV-seroprevalence in lambs. Res Vet Sci 2005, 78, 237-243.
• 2. Alvarez V., Daltabuit-Test M., Arranz J., Leginagoikoa I., Juste R.A., Amorena B., de Andrés D., Luján_L.L., Badiola J.J., Berriatua E.: PCR detection of colostrum-associated Maedi- Visna virus (MVV) infection and relationship with ELISA- antibody status in lambs. Res Vet Sci 2006, 80, 226-234.
• 3. Berriatua E., Alvarez V., Extramiana B., Gonzales L., Daltabuit M., Juste R.: Transmission and control implications of seroconversion to Maedi-Visna virus in Badque dairy-sheep flocks. Prev Vet Med 2003, 60, 265-279.
• 4. Blacklaws B., Berriatua E., Tortteindottir S., Watt N., Andres D., Klein D., Harkiss G: Transmission of small ruminant lentiviruses. Vet Microbiol 2004, 101, 199-208.
• 5. Brinkhof J., Maanen C., Wigger R., Peterson K., Houvers D.: Specific detection of small ruminant lentiviral nucleic acid sequences located in the proviral long terminal repeat and leadergag regions using real-time polymerase chain reaction. J Virol. Methods 2008, 147, 338-344.
• 6. Brodie S.J., de la Concha-Bermejillo A., Koenig G., Snowder G.D., DeMartini J.C.: Maternal factors associated with prenatal transmission of ovine lentivirus. J Infect Dis 1994, 169, 653-657.
• 7. Broughton-Neiswanger L.E., White S.N., Knowles D.P., Mousel M.R., Lewis G.S., Herndon D.R., Hermann-Hoesing L.M.: Non-maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock: A molecular epidemiology study. Infect. Genet Evol 2010, 10, 998-1007.
• 8. Cutlip R.C., Laird G.A.: Isolation and characterization of a virus associated with progressive pneumonia (maedi) of sheep. Am J Vet Res 1976, 37, 1377-1382.
• 9. De Boer G.F., Terpstra C., Houwers D.J., Hendriks J.: Studies on epidemiology of maedi/visna in sheep. Res Vet Sci 1979, 26, 202-208.
• 10. Germain K., Valas S.: Distribution and heterogeneity of small ruminant lentivirus envelope subtypes in naturally infected French sheep. Virus Res 2006, 120, 156-212.
• 11. Gutierrez G., Alvarez I., Rondelli F., Trono K.: Dynamics of perinatal bovine leukemia virus infection. BMC Vet Res 2014, 10, 82.
• 12. Herrmann-Hoesing L.M., Palmer G.H., Knowles D.P.: Evidence of proviral clearance following postpartum transmission of an ovine lentivirus. 2007. Virology 362, 226-234.
• 13. Houwers D.J., König C.D., de Boer G.F., Schaake J.Jr.: Maedivisna control in sheep. I. Artificial rearing of colostrum-deprived lambs. Vet Microbiol 1983, 8, 179-185.
• 14. Juste R.A., Kwang J., de la Concha-Bermejillo A.: Dynamics of cell-associated viremia and antibody response during the early phase of lentivirus infection in sheep. Am J Vet Res 1998, 59, 563-568.
• 15. Kaba J., Rola M., Materniak M., Kuźmak J., Nowicki M.: Isolation and characterization of caprine arthritis encephalitis virus in goats from Poland. Pol J Vet Sci 2009, 12, 183-188.
• 16. Kaba J., Czopowicz M., Ganter M., Nowicki M., Witkowski L., Nowicka D., Szaluś-Jordanow O.: Risk factors associated with seropositivity to small ruminant lentiviruses in goat herds. Res Vet Sci 2013, 94, 225-227.
• 17. Kuhar U., Barlic-Maganja D., Grom J.: Development and validation of Taqman probe based real time PCR assays for the specific detection of genotype A and B small ruminant lentivirus strains. BMC Vet Res 2013, 9, 172.
• 18. Kuźmak J., Rola M., Gallay K., Chebloune Y.: Molecular characterization of lentiviruses from goats from Poland based on gag gene sequence analysis. Comp Immunol Microbiol Infect Dis 2007, 30, 211-223.
• 19. Lynne L., Jo Burkhard M., Hoovers E.: Frequent perinatal transmission of feline immunodeficiency virus by chronically infected cats. J Virol 1996, 70, 2894-2901.
• 20. Moriuchi H., Masuzaki H., Doi H., Katamine S.: Mother-to-child transmission of human T-cell lymphotropic virus type 1. Pediatr Infect Dis J 2013, 32, 175-177.
• 21. Mordasini F., Vogt H.R., Zahno M.L., Maeschli A., Nenci C., Zanoni R., Peterhans E., Bertoni G.: Analysis of the antibody response to an immunodominant epitope of the envelope glycoprotein of a lentivirus and its diagnostic potential. J Clin Microbiol 2006, 44, 981-991.
• 22. Olech M., Rachid A., Croise B., Kuźmak J., Valas S.: Genetic and antigenic characterization of small ruminant lentiviruses circulating in Poland. Virus Res 2012, 163, 528-536.
• 23. Olech M., Kuźmak J., Osiński Z., Welz M.: Analysis of small ruminant lentivirus infection in sheep from the Małopolska and Podkarpackie voivodeships. Med Weter 2012, 68 ,705-768.
• 24. Peterhans E., Greenland T., Badiola J., Harkiss G., Bertoni G., Amorena B., Eliaszewicz M., Juste R.A., Kraßnig R., Lafont J.P., Lenihan P., Pétursson G., Pritchard G., Thorley J., Vitu Ch., Mornex J.F., Pépin M.: Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes. Vet Res 2004, 35, 257-274.
• 25. Preziuso A., Renzoni G., Allen T.E., Taceini E., Rossi G., DeMartini J.C., Braca G.: Colostral transmission of maedi visna virus: sites of viral entry in lambs born from experimentally infected ewes. Vet Microbiol 2004, 104, 157-164.
• 26. Reina R., Berriatua E., Luján L., Juste R., Sánchez A., de Andrés D., Amorena B.: Prevention strategies against small ruminant lentiviruses: an update. Vet J 2009, 182, 31-37.
• 27. Valas S., Benoit C., Guionaud C., Perrin G., Mamoun R.Z.: North American and French caprine arthritis-encephalitis viruses emerge from ovine maedi-visna viruses. Viruses 1997, 237, 307-318.