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1988 | 39 | 4 |

Tytuł artykułu

Central action of sanumgerman administered orally in mice

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Kleinrok, Z., Lekim, D. and Jagiełło-Wójtowicz, E.: Central action of sanumgerman administered orally in mice. Acta physiol, pol., 1938, 39 (4): 244-253. The behavioral and biochemical studies showed that daily oral administration ol sanumgerman (340 mg/kg, i.e. 1/5 LD₅₀ ) for 3 days exerted a depressive influence on the central nervous system of the mouse. The mechanism of this action could be related to an inhibition of cate- cholaminergic and of serotoninergic central system activities.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

39

Numer

4

Opis fizyczny

p.244-253,fig.,ref.

Twórcy

autor
  • Laboratory of Pharmacology, Institute of Plantes, Cologne, Germany
autor
  • Laboratory of Pharmacology, Institute of Plantes, Cologne, Germany
  • Department of Pharmacology, School of Medicine, Lublin, Poland

Bibliografia

  • 1. Asani, J. A., Legha, S. L., Burgess, M. A., Bodey, G. P. (1932) Phase I study of spirogermanium (9PG) given for five consecutive days iper week (Abstract). Proc. Amer. Soc. Clin. Oncol. 1. 16.
  • 2. Badger, A. M., Mirabelli, Ch. K., Di Martino, M. (1985) Generation of suppressorcells in normal rats by treatment with spirogermanium, a novel heterocyclic anticancer drug. Immunopharmacology 10. 201-207.
  • 3. Boissier, J. R., Simon, P., Lwoff, J. M. (1964) L’utilisation d'une reaction particuliere de la socuris (methode de la planche á trous) ipour l’etude des médicaments psychotropes. Therapie 19. 571-574.
  • 4. Brodie, В. B., Comer, M. S., Costa, E., Dlabac, A. (1966) The role of brain serotonin in the mechanism of the central action of reserpine. J. Pharmacol. Exp. Ther. 152. 340-349.
  • 5. Chang, С. C. (1964) A sensitive method for speotrofluorometric assay of catechol amines. Int. J. Neuropharmacol. 3. 643-649.
  • 6. Curzon, G., Green, A. R. (1970) Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat, brain. Brit. J. Pharmacol. 39. 653-655.
  • 7. Eddy, N. B., Leimbach, D. -(1953) Synthetic analgesics. Ш. Dithienylbutenyl and dithienyl-buitylamincs. J. Pharmacol. Exp. Ther. 107. 385-391.
  • 8. Eisenhauer, E., Kerr, 3., Bodurtha, A., Iscoe, N., McCulloch, P., Pritchard, K., Quirt, I. (1985) A phase 11 study of spirogermanium in patients with metastatic malignant melanoma, invest. New. Drugs 3. 303-305.
  • 9. Gross, F., Tripod, I., Meier, R. (1955) Zur pharmakologischen Charakterisierung des Schlafmittels Doriden. Schweiz. Med. Wschr. 85. 305-309.
  • 10. Kleinrok, Z., Lekim, D., Jagiełło-Wójtowicz, E., Chodkowska, A. (1986) Central action of sanuimgerman in mice. Pol. J. Pharmacol. Pharm. 38. 299-307.
  • 11. Lekim, D., Kehlbeck, H. (19-83) The metabolism of germanium in. the mammal. 8th Congress oi the Polish Pharmacological Society, September, Warsaw, p. 256, 26-23.
  • 12. Litchfield, J. T., Wilcoxon, F. (1949) A simplifield method of evaluating dose effeot experiments. J. Pharmacol. Exp, Ther. 96. 99-113.
  • 13. Paipeschi, R. (1975) Behavioral and biochemical interaction between AMT and ( + )-amphetamine: Relevance to the identification of the functional pool of brain catecholamines. Psychopharmacologia (Berlin/ 45. 21-28.
  • 14. Samochowiec, L., Wójcicki, J. (1984) Basic pharmacological properties of sanum- german. First International Workshop on Germanium, Hannover, October 13.
  • 15. Schein, S., Slavik, M., Smytha, T., Roth, D., Smith, F., MacDonald, J. S., Wodlley, P. V. (1930) Phase I clinical trial of spirogermanium. Cancer Treat. Rep. 64. 1051-1056.
  • 16. Sutton, I., Simmonds, M. A. (1984) Effects of acute chronic pentobarbitane on the Y-aminobutyric acid system in rat brain. Biochem. Pharmacol. 23. .1801-1808.
  • 17. Tozer, T. Z., Neff, N. H., Brodie, В. B. (1966) Application of steady state kinetics to the ibrain synthesis rate and turnover time, of serotonin in the normal and reserpine treated Tats. J. Pharmacol. Exp. Ther. 163. 177-182.
  • 18. Trope, I., Mattson, W., Gynning, L, Jahnsson, J. E., Sigurdsson, Ch., Orbert, B. (1981) Phase И study of spirogermanium in advanced ovarian malignancy. Cancer Treat. Rep. 65. 119-120.
  • 19. Zetler, G., Moog, E. (1958) Die Bullbocapnin-Katatonie, ihre Synergisten and Antagonisten. Arch. Exp. Path. Pharmacol. 232, 442-445.

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Bibliografia

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