Distribution of CD4plusCD8plus double positive T cells in a mouse model of allergic asthma

• Autorzy: Zuska-Prot M. , Ziolkowski H. , Jaroszewski J.J. , Maslanka T.
• Języki publikacji: EN

Abstrakty

EN

The present study describes the distribution of CD4+CD8+ double-positive (DP) T cells in various immune compartments of mice with ovalbumin (OVA)-induced allergic asthma. It was found that the absolute number of DP T cells was considerably increased in the mediastinal lymph nodes and lungs of asthmatic mice as compared with that determined in the healthy subjects. On the contrary, the absolute counts of DP T cells was significantly decreased in the head and neck lymph nodes, and in peripheral blood of OVA-immunized mice. These results suggest that DP T cells may be involved in the pathogenesis of allergic asthma.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2016
• Tom: 19
• Numer: 1
• Opis fizyczny: p.217-219,fig.,ref.

Twórcy

autor

Zuska-Prot M.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland

autor

Ziolkowski H.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland

autor

Jaroszewski J.J.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland

autor

Maslanka T.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland

Bibliografia

• Lambrecht BN, Hammad H (2003) Taking our breath away: dendritic cells in the pathogenesis of asthma. Nat Rev Immunol 3: 994-1003.
• Nam K, Akari H, Terao K, Shibata H, Kawamura S, Yoshikawa Y (2000) Peripheral blood extrathymic CD4(+)CD8(+)T cells with high cytotoxic activity are from the same lineage as CD4(+)CD8(-) T cells in cynomolgus monkeys. Int Immunol 12: 1095-1103.
• Parel Y, Chizzolini C (2004) CD4+CD8+ double positive (DP) T cells in health and disease. Autoimmun Rev 3: 215-220.
• Quandt D, Rothe K, Scholz R, Baerwald CW, Wagner U (2014) Peripheral CD4CD8 double positive T cells with a distinct helper cytokine profile are increased in rheumatoid arthritis. PLoS One 9: e93293.

Identyfikatory

DOI

10.1515/pjvs-2016-0026