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2016 | 19 | 1 |

Tytuł artykułu

Experimental osteoporosis in sheep - mechanical and histological approach

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The implementation of new methods of osteoporotic therapy requires tests on animal model. The use of sheep as model has numerous advantages over other animals. The aim of this study was to describe the change in parameters in sheep with osteoporosis induced using steroids and ovariorectomy methods as opposed to the parameters in healthy sheep. The study was performed on female „merinos” breed sheep divided into the three groups: negative control (NC) – healthy animals, positive control (PC) – ovariorectomized animals and steroid control group (SC) – in which methylprednisolone was administered. This paper presents histological and ultrastructural examination with mechanical comparative tests for force/strength values as well as indentation tests of joint cartilage. The obtained results confirm the loss of bone mass associated with mineral composition content in bones, which has an influence on bone strength.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

19

Numer

1

Opis fizyczny

p.109-118,fig.,ref.

Twórcy

  • Department and Clinic of Surgery, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 51, 50-366 Wroclaw, Poland
autor
  • Department and Clinic of Surgery, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 51, 50-366 Wroclaw, Poland
autor
  • Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
autor
  • Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
autor
  • Department of Biomedical Engineering and Experimental Mechanics, Wroclaw University of Technology, Wroclaw, Poland
autor
  • Department and Clinic of Surgery, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 51, 50-366 Wroclaw, Poland
  • Department and Clinic of Surgery, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 51, 50-366 Wroclaw, Poland
autor
  • Department of Biomedical Engineering and Experimental Mechanics, Wroclaw University of Technology, Wroclaw, Poland
autor
  • Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
autor
  • Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Wroclaw, Poland

Bibliografia

  • An YH, Gruber HE (2003) Introduction to Experimental Bone and Cartilage Histology. In: An YH, Martin KL (eds) Handbook of Histology Methods for Bone and Cartilage, 1st ed., Totowa, NJ, Human Press Inc, pp 3-31.
  • Bartl R, Frish B, von Tresckow E, Bartl C (2007) Bisphosphonates in medical practise actions-side effects-indications-strategies, Springer, pp 33-95.
  • Chavassieux P, Pastoureau P, Chapuy MC, Delmas PD, Meunier PJ (1993) Glucocortikoid-induced inhibition of osteoblastic bone formation in ewes: a biomechanical and histomorphometric study. Osteoporos Int 3: 102.
  • Chavassieux P, Buffet A, Vergnaud P, Garnero P, Meunier PJ (1997) Short-term effects of corticosteroids on trabecular bone remodeling in old ewes. Bone 20: 451-455.
  • Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359: 1761-1767.
  • David P, Nguyen H, Barbier A, Baron R (1996) The bisphosphonate tulidronate is a potent inhibitor of the osteoclast vacuolar H+ ATPase. J Bone Miner Res, 11: 1498-1507.
  • Ding M, Cheng L, Bollen P, Schwarz P, Overgaard S (2010) Glucocorticoid induced osteopenia in cancellous bone of sheep: validation of large animal model for spine fusion and biomaterial research. Spine 35: 363-370.
  • Lill CA, Fluegel AK, Schneider E (2002) Effect of ovariectomy, malnutrition and gluco-corticoid application on bone properties in sheep: a pilot study. Osteoporos Int 13: 480-486.
  • Meena D, Jun-Kyo S, Takashi M, Savio LY Woo (1995) Interspecies variation of compressive biomechanical properties of the meniscus. Journal of Biomedical Materials Research 29: 823-828.
  • Newton BI, Cooper RC, Gilbert JA, Johnson RB, Zardiackas LD (2004) The ovariectomized sheep as a model for human bone loss. J Comp Path 130: 323-326.
  • Oheim R, Amling M, Ignatius A, Pogoda P (2012) Large animal model for osteoporosis in humans: the ewe. Eur Cell Mater 24: 372-385.
  • Poole KE, Compston JE (2006) Osteoporosis and its management. BMJ 333: 1251-1256.
  • Proctor CS, Schmidt MB, Whipple RR, Kelly MA, Mow VC (1989) Material properties of the normal medial bovine meniscus. J Orthop Res 7: 771-782.
  • Schorlemmer S, Gohl C, Iwabu S, Ignatius A, Claes L, Augat P (2003) Glucocorticoid Treatment of Ovariectomized Sheep Affects Mineral Density, Structure, and Mechanical Properties of Cancellous Bone. J Bone Miner Res 18: 2010-2015.
  • Spławiński J, Remiszewska M, Pawluczuk D, Jastrzębski Z, Mazurek AP (1997) Bisphosphonates. A breakthrough in the treatment of osteoporosis. Therapy 10: 24-26.
  • Sweigart MA, Athanasiou KA (2005) Biomechanical characteristics of the normal medial and lateral porcine knee menisci. Proc Inst Mech Eng H 219: 53-62.
  • Teti A, Zallone A (2009) Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited. Bone 44(1): 11-6.
  • Turner AS, Alvis M, Myers W, Stevens ML, Lundy MW (1995) Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. Bone 17: S395-S402.

Typ dokumentu

Bibliografia

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Identyfikator YADDA

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