Optimisation of synthetic medium composition for levorin biosynthesis by Streptomyces levoris 99/23 and investigation of its accumulation dynamics using mathematical modelling methods

• Autorzy: Stanchev V.S. , Kozhuharova L.Y. , Zhekova B.Y. , Gochev V.K.
• Języki publikacji: EN

Abstrakty

EN

The composition of a synthetic culture medium for levorin biosynthesis by Streptomyces levoris 99/23 was optimised using mathematical modelling methods. The optimal concentrations of the medium components were established by means of an optimum composition design at three factor variation levels. An adequate regression model was obtained. Levorin biosynthesis by Streptomyces levoris 99/23 in the optimised synthetic medium was over 38% higher than in the initial medium. The antibiotic biosynthesis dynamics in the optimised culture medium was studied by means of a non-linear differential equation system. The resultant model was valid.

Słowa kluczowe

EN

antifungal preparation; levorin biosynthesis; synthetic medium; composition; biosynthesis; Streptomyces levoris; accumulation dynamics; mathematical modelling

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2010
• Tom: 59
• Numer: 3
• Opis fizyczny: p.179-183,fig.,ref.

Twórcy

autor

Stanchev V.S.

• Department of Automatics, Information and Control Systems, University of Food Technologies, Plovdiv, Bulgaria

autor

Kozhuharova L.Y.

• Department of Biotechnology, University of Food Technologies, Plovdiv, Bulgaria

autor

Zhekova B.Y.

• Department of Biochemistry and Molecular Biology, University of Food Technologies, Plovdiv, Bulgaria

autor

Gochev V.K.

• Department of Biochemistry and Microbiology, P. Hilendarski University, Plovdiv, Bulgaria

Bibliografia

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