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2017 | 26 | 6 |
Tytuł artykułu

Cytotoxicity and antimicrobial activity of pivalic and benzoic acid complexed Cu and Mn complexes

Warianty tytułu
Języki publikacji
PL
Abstrakty
The complexes of Cu and Mn metals with carboxylates (pivalic acid and benzoic acid) and imidazole were prepared and characterized. The synthesized complexes were screened for antimicrobial activity and cytotoxicity. The FTIR technique was used for characterization. The antibacterial assay revealed that the ligand and complexes are active against Escherichia coli, Staphylococcus aureus and Pasteurella multocida bacterial strains. The haemolytic assay revealed that [Cu(imi)(N₃)] and [MnIII(piv)(imi)(N₃)] were nontoxic, whereas [Cu(piv)(imi)] and [MnIII(Benz)(imi)(OCH₃)] showed moderate toxicity, and [Mn(Him)(N₃)₂] was highly toxic against human red blood cells (RBCs). Results revealed that Cu and Mn complexes with carboxylates (pivalic acid and benzoic acid) have antimicrobial activities. However, haemlytic assay revealed that the metal complex cytotoxicity was variable and biological activity evaluatuion of newly synthesized metals complexes is suggested for safe applications.
Słowa kluczowe
PL
Wydawca
-
Rocznik
Tom
26
Numer
6
Opis fizyczny
p.2861-2867,fig.,ref.
Twórcy
autor
  • Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan
autor
  • Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan
autor
  • Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan
autor
  • Department of Applied Chemistry and Biochemistry, GC University, Faisalabad, Pakistan
autor
  • Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan
autor
  • Jhang-Campus, University of Veterinary & Animal Sciences Lahore, Pakistan
autor
  • Department of Applied Chemistry and Biochemistry, GC University, Faisalabad, Pakistan
autor
  • Jhang-Campus, University of Veterinary & Animal Sciences Lahore, Pakistan
autor
  • Department of Chemistry, GC University, Faisalabad, Pakistan
autor
  • Department of Applied Chemistry and Biochemistry, GC University, Faisalabad, Pakistan
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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