Extracellular cortical serotonin and depression-related behavior in the forced swim test is influenced by interleukin-2

• Autorzy: Karrenbauer B. , Mueller C. , Schwarting R. , Spanagel R. , Pawlak C.
• Języki publikacji: EN

Abstrakty

EN

It is assumed that cytokines (like interleukins) can infl uence depression and anxiety. Interleukin-2 (IL-2) is suggested to be one factor, which may mediate behavioural and neurochemical (e.g., serotonergic) features of depression in the brain. Previously, we have shown in rats that IL-2 mRNA in the striatum and prefrontal cortex is correlated with anxiety-like avoidance behaviour in an elevated plus-maze. Additionally, striatal IL-2 microinjections affected anxiety-like behaviour in a biphasic way. In the present study, we investigated the impact of systemically (i.p.) injected IL-2 (2.5 μg/kg) on serotonegic (5-HT) and dopaminergic neurotransmission in various cortical areas by in-vivo microdialysis in anaesthetised rats (Exp. 1). Furthermore, based on the serotonergic time profi le, we conducted two experiments to test for delayed (test 2 h post injection, Exp. 2) and acute (Exp. 3) behavioural effects of systemic IL-2 (0–5 μg/kg) on depression-related behaviour in a forced swim test (FST). The neurochemical results revealed that systemic IL-2 lastingly reduced extracellular 5-HT levels in the medial prefrontal (−75%), occipital (−70%), and temporal cortices (−45%). In contrast, dopamine was moderately reduced only in the medial prefrontal cortex. The functional relevance of these specifi c neurochemical changes were supported by the subsequent behavioural evaluation showing IL-2 dose-dependent effects on depression-related behaviour in the FST after delayed testing.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.353

Twórcy

autor

Karrenbauer B.

• Department of Physiological Psychology, Phillips University Marburg, Marburg, Germany

autor

Mueller C.

• Institute of Psychiatry, King’s College, London, UK

autor

Schwarting R.

• Department of Physiological Psychology, Phillips University Marburg, Marburg, Germany

autor

Spanagel R.

• Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany

autor

Pawlak C.

• Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany