PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2014 | 58 | 1 |

Tytuł artykułu

Screening method for the determination of selected tetracyclines in water by liquid chromatography with diode array detector

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
A chromatographic procedure for determination of oxytetracycline (OXT), tetracycline (TC), chlortetracycline (CTC), and doxycycline (DC) in water samples was developed and was applied for the analysis of water samples collected from poultry and pig farms and environmental water samples. Samples were acidified with trifluoroacetetic acid to pH 3 and further purified by solid phase extraction using Oasis HLB cartridges. The samples were dried up and redissolved in the mixture of oxalic acid and methanol. Separation was performed on reserved phase column (Phenomenex column C₁₈, 250 mm × 4.6 mm, 5 µm) by multistep gradient elution, and detection was carried out at 360 nm for OTC and TC, 370 nm for CTC, and 350 nm for DC. The tetracyclines were eluted with the mobile phase of 0.05 M oxalic acid (pH 2.5), acetonitrile, and methanol. This method provided average recoveries of 83.53% to 108.59%, with coefficient of variations (CVs) of 2.41% to 8.64% in the range of 10 to 1000 µg/I. OTC, TC, CTC, and DC in water. The linearity for the tetracyclines was determined by HPLC-DAD in the range 10 to 1000 µg/L, with the correlation coefficient (R) > 0.99. The LOD and LOQ for the tetracyclines in water samples ranged from 1.51 to 4.00 and 2.51 to 5.93 µg/L, respectively.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

58

Numer

1

Opis fizyczny

p.65-70,fig.,ref.

Twórcy

autor
  • Department of Hygiene of Animal Feedingstuffs National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Hygiene of Animal Feedingstuffs National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Hygiene of Animal Feedingstuffs National Veterinary Research Institute, 24-100 Pulawy, Poland

Bibliografia

  • 1. Babić S., Asperger D., Mutavdzić D., Horvat A.J.M., Kastelan - Macan M.: Solid phase extraction and HPLC determination of veterinary pharmaceuticals in wastewater. Talanta 2006, 70, 732-738.
  • 2. Blanchflower W.J., McCracken R.J., Haggan A S., Kennedy D.G.: Confirmatory assay for the determination of tetracycline, oxytetracycline, chlortetracycline and its isomers in muscle and kidney using liquid chromatography-mass spectrometry J Chromatogr B 1997, 692, 351-360.
  • 3. Charlet M., Schelkens M., Croubels S., De Backer P.: Quantitative multi-residue analysis of tetracyclines and their 4- epimers in pig tissues by high-performance liquid chromatography combined with positive-ion electrospray ionization mass spectrometry. Anal Chim Acta 2003, 492, 199-213.
  • 4. Cheng Y.F., Phillips D.J., Neue U.: Simple and rugged SPE method for the determination of tetracycline antibiotics in serum by HPLC using a volatile mobile phase. Chromatographia 1997, 44, 187-190.
  • 5. Cinquina A.L., Longo F., Anastasi G., Giannetti L., Cozzani R.: Validation of a high-performance liquid chromatography method for the determination of oxytetracycline, tetracycline, chlorotetracycline and doxycycline in bovine milk and muscle. J Chromatogr A 2003, 987, 227-233.
  • 6. Cooper A.D., Stubbings G.W.F., Kelly M., Tarbin J.A., Farrington W.H.H., Shearer G.: Improved method for the on-line metal chelate affinity chromatography-high-performance liquid chromatographic determination of tetracycline antibiotics in animal products. J Chromatogr A 1998, 812, 321-326.
  • 7. Croubels S.M., Vanoosthuyze K.E.I., Van Peteghem C H.: Use of metal chelate affinity chromatography and membranebased ion-exchange as clean-up procedure for trace residue analysis of tetracyclines in animal tissues and egg. J Chromatogr A 1997, 690, 173-179.
  • 8. Furusawa N.: Isolation of tetracyclines in milk using a solid-phase extracting column and water eluent. Talanta 2003, 59, 155-159.
  • 9. Gajda A., Posyniak A., Żmudzki J., Tomczyk G.: Determination of doxycycline in chicken fat by liqud chromatogarphy with UV detection and liquid chromatography-tandem mass spectrometry. J Chromatogr B 2013, 928, 113-120.
  • 10. Hirsch R., Terens T.A., Haberer K., Mehlich A., Ballwanz F., Kratz K.L.: Determination of antibiotics in different water compartments via liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 1998, 815, 213-223.
  • 11. Jia A., Xiao Y., Hu J., Asami M., Kunikane S.: Simultaneoous determination of tetracyclines and their degradation products in envimmental waters by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 2009, 1216, 4655-4662.
  • 12. Monser L., Darghouth F.: Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics an 6-Epi-doxycycline in pharmaceutical products using porous graphitic carbon column. J Pharm Biomed Anal 2000, 23, 353 - 362.
  • 13. Nozal L., Arce L., Simont B.M., Rios A., Valcarcel M.: Rapid determination of trace levels of tetracyclines in surface water using a continuous flow manifold coupled to a capillary electrophoresis system. In: Chemical Analysis for Antibiotics Used in Agriculture. Edited by Oka H., Nakazawa H., Harada K.I., MacNeil J.D. AOAC Inter Arlington, USA, 1995, p. 333.
  • 14. Pena A., Carmona A., Barbosa A., Lino C., Silveira I., Castillo B.: Determiantion of tetracycline and its major degradation products by liquid chromatography with fluorescence detection. J Chromatogr A 2003, 987, 227-233.
  • 15. Posyniak A., Mitrowska K., Żmudzki J., Niedzielska J.: Analytical procedure for the determination of chloroteracycline and 4-epi-chlorotetracykline in pig kidneys. J Chromatogr A 2005,1088, 169-174
  • 16. Reverte S., Borrull F., Pocurull E., Marce R.M.: Determination of antibiotic compounds in water by solid-phase extraction high performance liquid chromatography (electrospray) mass spectrometry. J Chromatogr A 2003, 1010, 225-232.
  • 17. Rick W., Fedeniuk S.R., McCurdy A.R.: Application of reversed-phase liquid chromatography and prepacked C18 cartridges for the analysis of Oxytetracycline and related compounds. J Chromatogr B 1996, 677, 291-297.
  • 18. Rodrigez Diaz R.C., Aguilar-Cabalos M.P., Gomez Hens A.: Simultaneous determination of ciprofloxacin and tetracyclines in biological fluids based on dual-lanthanide sensitized luminescence using dry reagent chemical technology. J Pharm Biomed Anal 2005, 37, 1101-1104.
  • 19. Rudek M.A., March C.L., Bauer K.S., Pluda J.M., Figg W.D.: High-performance liquid chromatography with mass spectrometry detection for quantitating COL-3, a chemically modified tetracycline, in human plasma. J Pharm Biomed Anal 2000, 22, 1003-1014.
  • 20. Tjornelund J., Honor-Hansen S.: Use of metal complexation in non aqueous capillary electrophoresis system for the separation and improved detection of tetracyclines. J Chroamtogr A 1997, 779, 235-243.
  • 21. Walsh J R., Walker L.V., Webber J.J.: Determination of tetracyclines in bovine and porcine muscle by high-performance liquid chromatography using solid-phase extraction J Chromatogr A 1992, 596, 211-216.
  • 22. Valverde S.R., Gil Garcia M.D., Martinez Galera M., Goicoechea H.C.: Determination of tetracyclines in surface water by partial least squares using multivariate calibration transfer to correct the effect of solid phase preconcentration in photochemically induced fluorescence signals. Anal Chim Acta 2006, 562, 85-93.
  • 23. Vienneau D.S., Kindberg C.G.: Development and validation of a sensitive method for tetracycline in gingival crevicular fluid by HPLC using fluorescence detection J Pharm Biomed Anal 1997, 16, 111-117.
  • 24. Vinas P., Balsalobre N., Lopez-Erroz C., Hernandez-Cordoba M.: Liquid chromatography with ultraviolet absorbance detection for the analysis of tetracycline residue in honey. J Chromatogr A 2004, 1022, 125-129.
  • 25. Yang Xio A.J., Hu J., Asami M., Kunikane S.: Simultaneous determination of tetracyclines and their degradation products in environmental waters by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 2009, 1216, 4655-4662.
  • 26. Zhu J., Snow D.D., Cassada D A., Monson S.J., Spalding R.F.: Analysis of Oxytetracycline, tetracycline, and chlorotetracycline in water using solid-phase extraction and liquid chromatography tandem mass spectrometry. J Chromatogr A 2001, 928, 177-186.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-67254f15-abf1-4b8f-a200-4509b70be042
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.