Antidepressant activity of ethanolic extract of oleo gum resins of Ferula asafoetida Linn
Treść / Zawartość
Objective. The study was undertaken to evaluate the antidepressant activity of ethanolic extract of Ferula asafoetida oleo gum resins. Materials and Methods. Five groups of rats (180–200g) and mice (20–30g) of both genders, each group comprising six animals, were used (i.e., normal, positive control, standard, FAEE 200mg/kg, and FAEE 400mg/kg treated groups). Forced swimming test (FST), Tail suspension test (TST), Potentiation of Norepinephrine-Induced Toxicity (PNEIT), Haloperidol- Induced Catalepsy (HIC), and Reserpine-Induced Hypothermia (RIH), were used as the validate models of depression in rodents. The study was confirmed by brain monoamines estimation (i.e. Dopamine, Norepinephrine and 5-HT), MAO levels and invivo antioxidant studies (CAT and SOD). Results. FAEE treated animals showed a significant and dose dependent effect on a decrease in immobility time in FST, TST, and decrease in catalepsy time in HIC. FAEE and imipramine (15mg/kg) showed a significant increase in body temperature in RIH, and also showed a potent lethality in PNEIT. FAEE treated animals showed a significant increase in the levels of brain monoamines, in vivo antioxidants, and a significant decrease in MAO levels. Conclusion. Results of present study indicate that FAEE has potent antidepressant-like activity, and this effect may be due to the anti-oxidant property of Ferulic acid and umbelliferone, or may be due to neuroprotective activity of other major phytoconstituents, e.g. flavonoids, phenolic acids and polysulfide compounds. To identify the particular compound responsible for the antidepressant-like activity required further molecular level studies.