The renal actions of oxytocin in the conscious rat

• Autorzy: Windle R.J. , Forsling M. L.
• Języki publikacji: EN

Abstrakty

EN

The renal actions of oxytocin were studied in the conscious unrestrained rat infused with 0.077 M saline at a rate of 150 µl/min. During the control period volume and sodium excretion reached stable equilibria, the rates being equal to those infused. Administration of oxytocin at 200 pmol/min produced plasma oxytocin levels of 26.0±2.1 pmol/1 and caused a significant diuresis and natriuresis. Renal responses could also be seen with a lower dose of 30 pmol/min which produced plasma levels of 5.1 ±0.5 pmol/1 while a dose of 15 pmol/min which produced no significant increase in the plasma oxytocin had no renal effect. It appears that oxytocin has a natriuretic action in concentrations within the physiological range.

Słowa kluczowe

EN

oxytocin; plasma level; natriuresis; diuresis; plasma osmolality; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1991
• Tom: 42
• Numer: 4
• Opis fizyczny: p.417-426,fig.,ref.

Twórcy

autor

Windle R.J.

• Department of Obstetrics and Gynaecology, United Medical and Dental Schools, St Thomas's Campus, London, U.K.

autor

Forsling M. L.

• Department of Obstetrics and Gynaecology, United Medical and Dental Schools, St Thomas's Campus, London, U.K.

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