Development of tolerance to pethidine in rats, pretreated or not, with beta-naphtoflavone or SKF 525 A

• Autorzy: Cenajek D. , Szczawinska K. , Chodera A. , Nowakowska E.
• Języki publikacji: EN

Abstrakty

EN

Cenajek, D., Szczawińska, K., Chodera, A. and Nowakowska, E.: Development of tolerance to pethidine in rats, pretreated or not, with ß-naphtoflavone or SKF 525 A. Acta physiol, pol., 1988, 39 (4): 281-287. Tolerance to the analgesic effect of pethidine (PD) in rats, treated with a dose of 15 mg/kg of the compound twice daily at 12 h intervals for 1-3 weeks, was assessed using both, heat and current irritating stitnuli, (Tolerance could be detected earlier by the current irritating method, .than by the hot plate technique. Pretreatment with β -naphtoflavone did only slightly affect the development of tolerance to the antinofciceptive effect of (PD. In contrast after one week of treatment with SKF 525 А PD retained its1 analgesic effect. The prolonged pretreatment with SKF 525 A did not prevent the development of tolerance to the analgesic effect of PD.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1988
• Tom: 39
• Numer: 4
• Opis fizyczny: p.281-287,fig.,ref.

Twórcy

autor

Cenajek D.

• Department of Pharmacology, School of Medicine, Poznan, Poland

autor

Szczawinska K.

• Department of Pharmacology, School of Medicine, Poznan, Poland

autor

Chodera A.

• Department of Pharmacology, School of Medicine, Poznan, Poland

autor

Nowakowska E.

• Department of Pharmacology, School of Medicine, Poznan, Poland

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