The experimental osteoporosis in sheep - clinical approach

• Autorzy: Kielbowicz Z. , Piatek A. , Biezynski J. , Skrzypczak P. , Kuropka P. , Kuryszko J. , Nikodem A. , Kafarski P. , Pezowicz C.
• Języki publikacji: EN

Abstrakty

EN

The implementation of new methods of oseoporotic therapy requires tests on an animal model. One of the best is the sheep, whose numerous advantages over other models are described in the literature. The aim of this study was induction of osteoporosis using steroids and ovariorectomy methods in sheep and description of the change in parameters with regard to healthy sheep. The study was performed on female „merino” breed sheep divided into three groups: Negative control (NC) healthy animals, positive control (PC) ovariorectomised animals and steroid group (SC) where methylprednisolone was implemented. Blood tests, diagnostic arthroscopy, quantitative computed tomography and X-Ray micro-tomography of bone were carried out. Blood tests revealed a decreased level of estrogens, progesterone and increased parathormone and cortisol levels in the SC group. A decrease in bone turnover markers and an increase in bone resorption markers in all groups were also noted. Diagnostic arthroscopy revealed osteoarthrosis in PC and SC groups. Radiological density tests showed a slight decrease in PC and NC groups whereas there was more than a triple decrease in SC. Results obtained from microCT showed quickly developing osteoporosis in the SC group, which is reflected in numerous parameters analysed in this study. The best effects for osteoporosis induction were obtained using ovariorectomised sheep with methylprednisolone injections.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2015
• Tom: 18
• Numer: 3
• Opis fizyczny: p.645-654,fig.,ref.

Twórcy

autor

Kielbowicz Z.

• Department and Surgery Clinic, Faculty of Veterinary Medicine, University of Environmental and Life Sciences in Wroclaw, Wroclaw, Poland

autor

Piatek A.

• Department and Surgery Clinic, Faculty of Veterinary Medicine, University of Environmental and Life Sciences in Wroclaw, Wroclaw, Poland

autor

Biezynski J.

• Department and Surgery Clinic, Faculty of Veterinary Medicine, University of Environmental and Life Sciences in Wroclaw, Wroclaw, Poland

autor

Skrzypczak P.

• Department and Surgery Clinic, Faculty of Veterinary Medicine, University of Environmental and Life Sciences in Wroclaw, Wroclaw, Poland

autor

Kuropka P.

• Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences in Wroclaw, Wroclaw, Poland

autor

Kuryszko J.

• Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences in Wroclaw, Wroclaw, Poland

autor

Nikodem A.

• Department of Biomedical Engineering and Experimental Mechanics, Wroclaw University of Technology, Wroclaw, Poland

autor

Kafarski P.

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, 50-370 Wroclaw, Poland

autor

Pezowicz C.

• Department of Biomedical Engineering and Experimental Mechanics, Wroclaw University of Technology, Wroclaw, Poland

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Identyfikatory

DOI

10.1515/pjvs-2015-0083