The role of hypothalamic glycine receptors in regulation of the male rat sexual behavior

• Autorzy: Zburavleva Z. , Volnova A. , Mukhina L. , Druzin M. , Lebedeva A.
• Języki publikacji: EN

Abstrakty

EN

Membrane-bound glycine receptors (GlyRs) mediate inhibition in many central neurons including hypothalamic neurons from the medial preoptic area (MPOA), known to be critically involved in reproductive behavior of all vertebrate species. To study the contribution of the abundant GlyRs present in this area to the male rat sexual behavior we used intracranial bilateral microinjection of the GlyR-targeting compounds delivered into MPOA through the chronically implanted stainless steel microcannulae. Several behavioral patterns such as session duration, duration of postejaculatory period, number of intromissions and ejaculations were routinely monitored using video registration. The data analysis revealed that the bilateral microinjection of glycine (1 mM) into the male rat MPOA reliably decreased the ejaculation latency period, the duration of the postejaculatory period and the number of intromissions. Interestingly, the bilateral microinjection of GlyR antagonist strychnine (20 μM) had similar effect on the ejaculation latency period and the number of intromission but not on the postejaculatory period. Thus, our results provide the first experimental evidence for the involvement of GlyRs expressed in MPOA in the regulation of the male sexual behavior and improve our understanding of the mechanisms underlying such behavior.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.355

Twórcy

autor

Zburavleva Z.

• Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia

autor

Volnova A.

• Saint Petersburg State University, Saint Petersburg, Russia

autor

Mukhina L.

• Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia
• Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia

autor

Druzin M.

• Umea University, Umea, Sweden

autor

Lebedeva A.

• Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia