Correlation between the expression of MCM-3 protein and Ki-67 antigen in mammary adenocarcinomas of dogs (short communication)

• Autorzy: Nowak M. , Madej J. A. , Dziegiel P.
• Języki publikacji: EN

Abstrakty

EN

The studies were aimed at the determination of MCM-3 expression intensity in cells of mammary adenocarcinomas in bitches using an immunohistochemical technique and at comparing the obtained results with expression intensity of Ki-67 antigen, representing an exponent of tumour cells proliferative activity. The material for the studies was sampled during surgical procedures from 16 bitches of various breeds, aging from 6 to 11 years, which developed mammary tumours. The neoplastic tumours were histopathologically verified as adenocarcinomas. Immunohistochemical reactions were performed in order to detect MCM-3 protein and Ki-67 antigen in the tumours. Microphotographs of the obtained preparations were subjected to computer-assisted image analysis using the MultiScaneBase V 14.02 software. A statistical analysis of the results demonstrated a positive, strong correlation (r = 0.57) between the expression of Ki-67 proliferation antigen and expression of MCM-3 protein in the adenocarcinomas. This may indicate the usefulness of the latter protein as a marker defining a proliferative potential of the tumour.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2008
• Tom: 52
• Numer: 4
• Opis fizyczny: p.701-705,fig.,ref.

Twórcy

autor

Nowak M.

• Department of Pathological Anatomy, Pathophysiology, Microbiology and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland

autor

Madej J. A.

• Department of Pathological Anatomy, Pathophysiology, Microbiology and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland

autor

Dziegiel P.

• Department of Histology and Embryology, Medical University, 50-368 Wroclaw, Poland

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