Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients

• Autorzy: Golembiewska E. , Safranow K. , Ciechanowski K. , Bober J. , Bogacka A. , Stepniewska J.
• Języki publikacji: EN

Abstrakty

EN

Aim: Adiponectin and leptin are two adipokines playing important roles in the regulation of body weight, appetite, carbohydrate and lipid metabolism. In patients with chronic kidney disease (CKD) adipokines accumulate in serum due to reduced renal clearance. Since adipokines have pleiotropic actions, the adipokine balance may have an impact on peritoneal membrane transport. The aim of this study was to assess whether serum adiponectin and leptin levels were related to peritoneal transport and residual renal function (RRF) in newly started peritoneal dialysis patients. Methods: 25 clinically stable patients, 4 to 6 weeks after the onset of PD, were included in the study. For each patient clinical and laboratory data were reviewed and standard PET test was performed. Serum adiponectin and leptin concentrations were determined and leptin/adiponectin (L/A) ratio was calculated. Results: Serum adiponectin correlated negatively with weight, BMI and glucose concentration. Serum leptin and L/A ratio correlated positively with BMI. Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test. Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance. Conclusions: Serum adiponectin concentration is positively associated with baseline solute transport. Leptin concentration and L/A ratio are negatively associated with dialysis adequacy in newly started PD patients.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 4
• Opis fizyczny: p.617-621,fig.,ref.

Twórcy

autor

Golembiewska E.

• Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland

autor

Safranow K.

• Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland

autor

Ciechanowski K.

• Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland

autor

Bober J.

• Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland

autor

Bogacka A.

• Department of Human Nutrition, West Pomeranian University of Technology, Szczecin, Poland

autor

Stepniewska J.

• Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland

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