The effects of dexamethasone and minocycline alone and combined with N-acetylcysteine and vitamin E on serum matrix metalloproteinase-9 and coenzyme Q10 levels in aflatoxin B1 administered rats

• Autorzy: Tras B. , Eser Faki H. , Ozdemir Kutahya Z. , Bahcivan E. , Dik B. , Uney K.
• Języki publikacji: EN

Abstrakty

EN

This study aimed to determine the effects of dexamethasone and minocycline alone and combined treatment with N-acetylcysteine (NAC) and vitamin E on serum coenzyme Q10 (CoQ10) and matrix metalloproteinase-9 (MMP-9) levels in rats administered aflatoxin B1 (AFB1). The study was carried out on 66 male Wistar rats. Following the intraperitoneal (IP) administration of AFB1 at dose of 2 mg/kg, minocycline (45 and 90 mg/kg, IP) and dexamethasone (5 and 20 mg/kg, IP) were administered alone and combined with NAC (200 mg/kg, IP) and vitamin E (600 mg/kg, IP). CoQ10 and MMP-9 levels were analyzed using the HPLC-UV method and a commercial kit by ELISA, respectively. AFB1 increased MMP-9 level and decreased CoQ10 level compared to the control group. After dexamethasone and minocycline administration, there is no increase in CoQ10 level, which is caused by AFB1. However, dexamethasone and minocycline combined with NAC+vitamin E caused significant increases in CoQ10 levels. Dexamethasone and minocycline alone and combined with NAC+vitamin E decreased MMP-9 levels compared to the single AFB1 treated group. The use of MMPs inhibitors and oxidative stress-reducing agents is anticipated to be beneficial in the poisoning with AFB1.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2022
• Tom: 25
• Numer: 3
• Opis fizyczny: p.419-427,fig.,ref.

Twórcy

autor

Tras B.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Alaeddin Keykubat Campus, New Istanbul Road. No:371, Konya, 42130, Turkey

autor

Eser Faki H.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Alaeddin Keykubat Campus, New Istanbul Road. No:371, Konya, 42130, Turkey

autor

Ozdemir Kutahya Z.

• Department of Pharmacology and Toxicology, Faculty of Ceyhan Veterinary Medicine, University of Cukurova, Fatih Sultan Mehmet District, Inonu Boulevard, No: 242, Adana, 01330, Turkey

autor

Bahcivan E.

• Department of Medical Pharmacology, Faculty of Medicine, University of Amasya, Akbilek District. Dominion Street, National Sovereignty Campus, No:4/3, 05100, Turkey

autor

Dik B.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Alaeddin Keykubat Campus, New Istanbul Road. No:371, Konya, 42130, Turkey

autor

Uney K.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Alaeddin Keykubat Campus, New Istanbul Road. No:371, Konya, 42130, Turkey

Identyfikatory

DOI

10.24425/pjvs.2022.142026