Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells

• Autorzy: Augustyniak J. , Zychowicz M. , Podobinska M. , Barta T. , Buzanska L.
• Języki publikacji: EN

Abstrakty

EN

Derivation of pluripotent stem cells from adult somatic tissues by reprogramming technology has opened new therapeutic possibilities. Current most efficient procedures for derivation of induced pluripotent stem (iPS) cells are based on the viral vectors, which represent the danger of insertional mutagenesis during incorporation of introduced genes into the host genome. To circumvent this problem, the new, safe, non-integrative and non-viral strategies of reprogramming have been developed. In this review we discuss novel DNA-free and viral-free methods of reprogramming to iPS cells including protein transduction, mRNA and microRNA delivery.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 4
• Opis fizyczny: p.373-382,fig.,ref.

Twórcy

autor

Augustyniak J.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Zychowicz M.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Podobinska M.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Barta T.

• International Clinical Research Center, St. Anne’s University Hospital, Brno, Czech Republic
• Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

autor

Buzanska L.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

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