Development of pulmonary oxygen toxicity in rats after hyperoxic exposure

• Autorzy: Siermontowski P. , Pedrycz A. , Konarski M. , Kaczerska D. , van Damme-Ostapowicz K. , Olszanski R. , Boratynski Z.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to examine the effects of hyperbaric oxygen on lung aeration on an animal experimental model and compare the obtained results with the anticipated scope of damage to pulmonary parenchyma in humans under the same exposure conditions. The research was carried out on Black Hood rats that were kept in a hyperbaric chamber designed for animals in an atmosphere of pure oxygen and at overpressures of 0.15, 0.2, 0.3, 0.4, and 0.5 MPa for 1, 2 or 4 h. After sacrificing the animals, histopathological specimens were obtained encompassing cross-sections of entire lungs, which were subjected to qualitative and quantitative examination with the use of the 121-point Haug-grid. A statistically significant decrease in pulmonary parenchyma was observed as a result of an increasing oxygen partial pressure as well as with prolonged exposure time. The intensification of changes observed was much higher than expected on the basis of calculations performed with the use of tables.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2014
• Tom: 58
• Numer: 2
• Opis fizyczny: p.305-310,fig.,ref.

Twórcy

autor

Siermontowski P.

• Department of Maritime and Hyperbaric Medicine Military Institute of Medicine, 81-103 Gdynia, Poland

autor

Pedrycz A.

• Department of Histology and Embryology with Laboratory of Experimental Cytology, Medical University of Lublin, 20-080 Lublin, Poland

autor

Konarski M.

• Department of Maritime and Hyperbaric Medicine Military Institute of Medicine, 81-103 Gdynia, Poland

autor

Kaczerska D.

• Department of Clinical Nutrition Medical University of Gdansk, 80-210 Gdansk, Poland

autor

van Damme-Ostapowicz K.

• Department of Integrated Medical Care Medical University of Bialystok, 15-096 Bialystok, Poland

autor

Olszanski R.

• Department of Maritime and Hyperbaric Medicine Military Institute of Medicine, 81-103 Gdynia, Poland

autor

Boratynski Z.

• Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences Lublin, 20-950 Lublin, Poland

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