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2013 | 16 | 2 |
Tytuł artykułu

Influence of mutation in cj0183 and cj0588 genes for colonization abilities of Campylobacter jejuni in Caco-2 cells using confocal laser scanning microscope

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The cj0183 and cj0588 genes identified in the Campylobacter jejuni NCTC 11168 genome encode proteins with homology to virulence factors found in other bacteria. Previous studies showed that single mutation in the cj0183 gene does not affect adhesion of C. jejuni to the Caco-2 cell line whereas protein encoded by cj0588 is involved in adherence to the Caco-2 cells. In the presented study differences in invasion index were observed between mutants in both genes and single mutation of cj0588 in 81116 and 81-176 C. jejuni strains. This fact indicates that Cj0183 protein might play some role in invasion of bacteria into host cells.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
16
Numer
2
Opis fizyczny
p.387-389,fig.,ref.
Twórcy
  • Division of Bacteriology and Molecular Biology, Department of Pre-Clinical Sciences, Warsaw University of Live Sciences – SGGW, Ciszewskiego 8, 02-786 Warsaw, Poland
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Live Sciences – SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland
autor
  • Division of Bacteriology and Molecular Biology, Department of Pre-Clinical Sciences, Warsaw University of Live Sciences – SGGW, Ciszewskiego 8, 02-786 Warsaw, Poland
Bibliografia
  • Dasti JI, Tareen AM, Lugert R, Zautner AE, Gross U (2010) Campylobacter jejuni: a brief overview on pathogenicity-associated factors and disease-mediating mechanisms. Int J Med Microbiol 300: 205-211.
  • Hanel I, Muller J, Muller W, Schulze E (2004) Correlation between invasion of Caco-2 eukaryotic cells and colonization ability in the chick gut in Campylobacter jejuni. Vet Microbiol 101: 75-82.
  • Hyatt DR, ter Huurne AA, van der Zeijst BA, Joens LA (1994) Reduced virulence of Serpulina hyodysenteriae hemolysin-negative mutants in pigs and their potential to protect pigs against challenge with a virulent strain. Infect Immun 62: 2244-2248.
  • Jin S, Joe A, Lynett J, Hani EK, Sherman P, Chan VL (2001) JlpA, a novel surface-exposed lipoprotein specific to Campylobacter jejuni, mediates adherence to host epithelial cells. Mol Microbiol 39: 1225-1236.
  • Martino MC, Stabler RA, Zhang ZW, Farthing MJ, Wren BW, Dorrell N (2001) Helicobacter pylori pore-forming cytolysin orthologue TlyA possesses in vitro hemolytic activity and has a role in colonization of the gastric mucosa. Infect Immun 69: 1697-1703.
  • McSweegan E, Walker RI (1986) Identification and characterization of two Campylobacter jejuni adhesins for cellular and mucous substrates. Infect Immun 53: 141-148.
  • Sałamaszyńska-Guz A, Klimuszko D (2008) Functional analysis of the Campylobacter jejuni cj0183 and cj0588 genes. Curr Microbiol 56: 592-596.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.agro-5f1071a4-b153-4b2a-b2f1-eaec2b8ddae2
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