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2015 | 18 | 4 |
Tytuł artykułu

Evaluation of selected serum biochemical and haematological parameters in gilts exposed per os to 100 ppb of zearalenone

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Zearalenone (ZEN) widely contaminates animal feed of plant origin. The recommended safe concentrations of ZEN in feeds for various animal species are set mainly based on the mycotoxin’s hormonal properties (NOEL). Our growing knowledge about biologically active concentrations of ZEN, molecular mechanisms and cells/tissues targeted by ZEN indicates that the harmful effects exerted by this mycotoxin on animals may be far greater than previously believed. This experiment was performed on pre-pubertal gilts divided into a control group (n=9) and an experimental group (ZEN, n=9). The control group received placebo, whereas the experimental group was administered ZEN at a dose of 0.1 mg/kg feed (equivalent to 5 μg/kg BW/day) for 42 days. On days 14, 28 and 42 blood samples were collected from the animals to determine the concentrations of selected zearalenols, serum biochemical and haematological parameters. Conjugated ZEN was found in the blood serum of the experimental gilts. Changes in the analysed biochemical parameters included a transient increase in albumin and cholesterol levels. A statistically significant increase in the concentrations of neutrophilic and acidophilic granulocytes was observed in the white blood cell system. The results indicate that long-term per os exposure of pre-pubertal gilts to low doses of ZEN (below NOEL) has a modulatory effect on liver function and white blood cells.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
18
Numer
4
Opis fizyczny
p.865-872,ref.
Twórcy
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-950 Olsztyn, Poland
autor
  • Department of Internal Diseases with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-950 Olsztyn, Poland
  • Department of Internal Diseases with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-950 Olsztyn, Poland
autor
  • Department of Environmental Biotechnology, Faculty of Environmental Science, University of Warmia and Mazury in Olsztyn, Sloneczna 45G, 10-709 Olsztyn, Poland
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-950 Olsztyn, Poland
autor
  • Departament of Epizzootiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-950 Olsztyn, Poland
autor
  • Department of Environmental Biotechnology, Faculty of Environmental Science, University of Warmia and Mazury in Olsztyn, Sloneczna 45G, 10-709 Olsztyn, Poland
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-950 Olsztyn, Poland
Bibliografia
  • Abbès S, Ouanes Z, ben Salah-Abbès J, Houas Z, Oueslati R, Bacha H, Othman O (2006) The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice. Toxicon 47: 567-574.
  • Abid-Essefi S, Bouaziz C, Golli-Bennour EE, Ouanes Z, Bacha H (2009) Comparative study of toxic effects of zearalenone and its two major metabolites alpha-zearalenol and beta-zearalenol on cultured human Caco-2 cells. J Biochem Mol Toxicol 23: 233-243.
  • Allan FJ, Thompson KG, James KA, Manktelow BW, Koolaard J, Johnson RN (2001) Serum lipoprotein cholesterol and triglyceride concentrations in pigs fed diets containing fish oil, milkfat, olive oil and coconut oil. Nutr Res 21: 785-795.
  • Al-Seeni M, El-Sawi N, Shaker S, Al-Amoudi A (2011) Investigation of the biochemical and histological changes induced by zearalenone mycotoxin on liver in male mice and the protective role of crude venom extracted fromn Jellyfish Cassiopea Andromeda. Food Nutr Sci 2: 314-322.
  • Barter PJ, Nicholls S, Rye KA, Anantharamaiah GM, Navab M, Fogelman AM (2004) Antiinflammatory properties of HDL. Circ Res 95: 764-772.
  • Bergstrøm H, Tonstad S (2006) Combined hormone replacement therapy improves lipids but may increase leucocytes. J Intern Med 259: 537-538.
  • Boeira SP, Filho CB, Del’Fabbro L, Roman SS, Royes LF, Fighera MR, Jessé CR, Oliveira MS, Furian AF (2014) Lycopene treatment prevents hematological, reproductive and histopathological damage induced by acute zearalenone administration in male Swiss mice. Exp Toxicol Pathol 66: 179-185.
  • Bryden WL (2012) Mycotoxin contamination of the feed supply chain: implications for animal productivity and feed security. Anim Feed Sci Tech 173: 134-158.
  • Chen XX, Yang CW, Huang LB, Niu QS, Jiang SZ, Chi F (2015) Zearalenone Altered the Serum Hormones, Morphologic and Apoptoticic Measurements of Genital Organs in Post-weaning Gilts. Asian-Australas J Anim Sci 28: 171-179.
  • Chighizola C, Meroni PL (2012) The role of environmental estrogens and autoimmunity. Autoimmun Rev 11: A493-A501.
  • D’Mello JPF, Placinta CM, Macdonald AM (1999) Fusarium mycotoxins: a review of global implications for animal health, welfare and productivity. Anim Feed Sci Tech 80: 183-205.
  • Dai S, Duan J, Lu Y, Zhang Y, Cheng J, Ren J, Zhao X, Wu Y, Yu Y, Zuo P, Wu Y, Ge Q (2004) Phytoestrogen alpha-zearalanol inhibits atherogenesis and improves lipid profile in ovariectomized cholesterol-fed rabbits. Endocrine 25: 121-129.
  • Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benett LZ (1993) Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proc Natl Acad Sci USA 90: 3797-3801.
  • Döll S, Dänicke S (2011) The Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) in animal feeding. Prev Vet Med. 102: 132-145.
  • Döll S, Dänicke S, Ueberschär KH, Valenta H, Schnurrbusch U, Ganter M, Klobasa F, Flachowsky G (2003) Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets. Arch Tierernahr 57: 311-334.
  • Dunbar B, Patel M, Fahey J, Wira C (2012) Endocrine control of mucosal immunity in the female reproductive tract: impact of environmental disruptors. Mol Cell Endocrinol 354: 85-93.
  • EC (European Commission) Recommendation (2006) Commission recommendation of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Off J Eur Union L229, 7-9 (23.8.2006).
  • EFSA (European Food Safety Authority) (2011) Opinion on the risks for public health related to the presence of zearalenone in food. EFSA J 9: 1-124.
  • El Golli-Bennour E, Bacha H (2011) Hsp70 expression as biomarkers of oxidative stress: mycotoxins’ exploration. Toxicology 287: 1-7.
  • Gajęcka M, Zielonka Ł, Dąbrowski M, Mróz M, Gajęcki M (2013) The effect of low doses of zearalenone and its metabolites on progesterone and 17β-estradiol concentrations in peripheral blood and body weights of pre-pubertal female Beagle dogs. Toxicon 76: 260-269.
  • Gazzah AC, Camoin L, Abid S, Bouaziz C, Ladjimi M, Bacha H (2013) Identification of proteins related to early changes observed in Human hepatocellular carcinoma cells after treatment with the mycotoxin Zearalenone. Exp Toxicol Pathol 65: 809-816.
  • Jia Z, Liu M, Qu Z, Zhang Y, Yin S, Shan A (2014) Toxic effects of zearalenone on oxidative stress, inflammatory cytokines, biochemical and pathological changes induced by this toxin in the kidney of pregnant rats. Environ Toxicol Pharmacol 37: 580-591.
  • Jiang S, Yang Z, Yang W, Gao J, Liu F, Chen C, Chi F (2010) Physiopathological effects of zearalenone in post-weaning female piglets with or without montmorillonite clay adsorbent. Livest Sci 131: 130-136.
  • Liehr JG, Somasunderam A, Roy D (1998) Natural and anthropogenic environmental oestrogens: the scientific basis for risk assessment. Metabolism and fate of xeno-oestrogens in man. Pure Appl Chem 70: 1747-1758.
  • Luongo D, De Luna R, Russo R, Severino L (2008) Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation. Toxicon 52: 156-162.
  • Lurie S, Rahamim E, Piper I, Golan A, Sadan O (2008) Total and differential leukocyte counts percentiles in normal pregnancy. Eur J Obstet Gynecol Reprod Biol 136: 16-19.
  • Maaroufi K, Chekir L, Creppy EE, Ellouz F, Bacha H (1996) Zearalenone induces modifications of haematological and biochemical parameters in rats. Toxicon 34: 535-540.
  • Maresca M, Fantini J (2010) Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases. Toxicon 56: 282-294.
  • Marin DE, Pistol GC, Neagoe IV, Calin L, Taranu I (2013) Effects of zearalenone on oxidative stress and inflammation in weanling piglets. Food Chem Toxicol 58: 408-415.
  • Marin DE, Taranu I, Burlacu R, Manda G, Motiu M, Neagoe I, Dragomir C, Stancu M, Calin L (2011) Effects of zearalenone and its derivatives on porcine immune response. Toxicol In Vitro 25: 1981-1988.
  • Marin ML, Murtha J, Dong W, Pestka JJ (1996) Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells. J Toxicol Environ Health 48: 379-396.
  • Matsuwaki Y, Wada K, Moriyama H, Kita H (2011) Human eosinophil innate response to Alternaria fungus through protease-activated receptor-2. Int Arch Allergy Immunol 155 Suppl 1: 123-128.
  • Obremski K (2014) Changes in Th1 and Th2 cytokines concentrations in ileal Peyer’s patches in gilts exposed to zearalenone. Pol J Vet Sci 17: 53-59.
  • Obremski K, Gajęcki M, Zwierzchowski W, Bakula T, Apoznański J, Wojciechowski J (2003) The level of zearalenone and alpha-zearalenol in the blood of gilts with clinical symptoms of toxicosis, fed diets with a low zearalenone content. J Anim Feed Sci 12: 529-538.
  • Ritter JK (2000) Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions. Chem Biol Interact 129: 171-193.
  • Songsermsakul P, Bohm J, Aurich C, Zentek J, Razzazi-Fazeli E (2013) The levels of zearalenone and its metabolites in plasma, urine and faeces of horses fed with naturally, Fusarium toxin-contaminated oats. J Anim Physiol Anim Nutr (Berl) 97: 155-161.
  • Šperanda M, Liker B, Šperanda T, Šerić V, Antunović Z, Grabarević Z, Senčić D, Grgurić D, Steiner Z (2006) Haematological and biochemical parameters of weaned piglets fed on fodder mixture contaminated by zearalenone with addition of clinoptilolite. Acta Vet-Beograd 56: 121-136.
  • Taranu I, Braicu C, Marin DE, Pistol GC, Motiu M, Balacescu L, Beridan Neagoe I, Burlacu R (2015) Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression. Toxicol Lett 232: 310-325.
  • Taverna M, Marie A-L, Mira J-P, Guidet B (2013) Specific antioxidant properties of human serum albumin. Ann Intensive Care 3: 4.
  • Teixeira LC, Montiani-Ferreira F, Locatelli-Dittrich R, Santin E, Alberton GC (2011) Effects of zearalenone in prepubertal gilts. Pesq Vet Bras 31: 656-662.
  • Videmann B, Mazallon M, Tep J, Lecoeur S (2008) Metabolism and transfer of the mycotoxin zearalenone in human intestinal Caco-2 cells. Food Chem Toxicol 46: 3279-3286.
  • Wang JP, Chi F, Kim IH (2012) Effects of montmorillonite clay on growth performance, nutrient digestibility, vulva size, faecal microflora, and oxidative stress in weaning gilts challenged with zearalenone. Anim Feed Sci Tech 178: 158-166.
  • Yang D, Chen Q, Su SB, Zhang P, Kurosaka K, Caspi RR, Michalek SM, Rosenberg HF, Zhang N, Oppenheim JJ (2008) Eosinophil-derived neurotoxin acts as an alarminto activate the TLR2 – MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med 205: 79-90.
  • Yu J, Chen D, Yu B (2009) Protective effects of selenium and vitamin E on rats consuming maize naturally contaminated with mycotoxins. Front Agric China 3: 95-99.
  • Yu L, Wang L, Chen S (2010) Endogenous toll-like receptor ligands and their biological significance. J Cell Mol Med 14: 2592-2603.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-5e7de0a7-8ec4-4ec3-a6a2-b009f74389b2
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