Serotonin receptors and site-selective agents

• Autorzy: Gelennon R.A.
• Języki publikacji: EN

Abstrakty

EN

Few site-selective serotonergic agents are currently available; in fact, most of these agents might more appropriately be termed semi-selective in that they typically bind to at least two different populations of serotonin receptors. We describe the application of structure-affinity relationship (SAFIR) studies to the development of high- affinity and/or site-selective serotonergic agents; examples are provided from work conducted in our laboratories. Also discussed is the concept of selectively non-selective agents and their potential preclinical and clinical utility. A case is made for development of selective and nonselective serotonergic agents.

Słowa kluczowe

EN

serotonin receptor; structure-affinity relationship; 5-HT receptor; site-selective agent; quantitative structure-activity relationship analysis; mathematical modelling; 5-HT1A receptor

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1991
• Tom: 42
• Numer: 1
• Opis fizyczny: p.49-60,fig.,ref.

Twórcy

autor

Gelennon R.A.

• Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0540, USA

Bibliografia

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