Mice lines divergently selected for body mass show significant differences in spatial learning

• Autorzy: Blecharz-Klin K. , Piechal A. , Pyrzanowska J. , Wirth-Dzieciolowska E. , Widy-Tyszkiewicz E.

Warianty tytułu

PL

Linie myszy poddane selekcji w kierunku wysokiej i niskiej masy ciała różnią się znamienie w uczeniu przestrzennym

• Języki publikacji: EN

Abstrakty

EN

The present study was aimed to investigate the influence of multigenerational selection in the direction of low or high body weight on spatial learning and memory in mice. Light and heavy lines of rodents were selected from an outbred stock constructed from inbred strains; A/St, BN/a, BALB/c and C57BL/6J. Male mice selected at weaning for the low (L, n=13) or high (H, n=16) body weight for 94 generations have been evaluated for behavioral performance and cognition in the modified Morris water maze task. The unselected control line (Con, n=15) was run in parallel. Presented results lead to the conclusion that selection of mice for high and low body weight over 94 generations resulted in a significant differentiation in learning abilities. Our findings suggest improvement of learning of the hidden platform position in heavy line of mice.

PL

Celem badania jest ocena wpływu wielopokoleniowej selekcji w kierunku niskiej lub wysokiej masy ciała na procesy uczenia się i pamięci przestrzennej u myszy. Obie linie gryzoni uzyskano w wyniku wielopokoleniowej selekcji z niekrewniaczej wsobnej hodowli myszy szczepów; A/St, BN/a, BALB/c i C57BL/6J. Zachowanie i funkcje poznawcze analizowano przy pomocy labiryntu wodnego Morrisa u 13 samców z linii lekkiej (L, n = 13) i 16 samców z linii ciężkiej (H, n = 16). Równolegle prowadzono linię kontrolną, z której do badania wybrano 15 samców (Con, n = 15). Prezentowane wyniki prowadzą do wniosku, że wielopokoleniowa selekcja myszy w kierunku wysokiej i niskiej masy ciała prowadzi do istotnego zróżnicowania w zakresie zdolności uczenia się. Nasze wyniki sugerują, że myszy z linii ciężkiej znacznie szybciej uczą się pozycji podwodnej platformy w teście labiryntu wodnego.

• Wydawca: -
• Czasopismo: Polish Journal of Natural Sciences
• Rocznik: 2015
• Tom: 30
• Numer: 1
• Opis fizyczny: p.21-34,fig.,ref.

Twórcy

autor

Blecharz-Klin K.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Piechal A.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Pyrzanowska J.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Wirth-Dzieciolowska E.

• Department of Genetics and Animal Breeding, Agricultural University of Warsaw, Warsaw, Poland

autor

Widy-Tyszkiewicz E.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
• Centre for PreclinicalResearch and Technology CePT, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland

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