Various factors affecting the alpha1-antitrypsin level in Thoroughbred foals

• Autorzy: Kulisa M. , Ormian M. , Stefaniuk-Szmukier M. , Ropka-Molik K. , Jagusiak W. , Podstawski Z.

Warianty tytułu

PL

Wpływ różnych czynników na poziom alfa1-antytrypsyny u żrebiąt pełnej krwi angielskiej

• Języki publikacji: EN

Abstrakty

EN

Acute phase proteins (APP) are an integral part of the acute phase response. Alpha 1 antitrypsin is considered to be one of the most important acute-phase protein activated by trauma, stress, or inflammatory processes. The objective of the present study was to estimate the impact of various factors (sex, month of life and sire effect) on concentration of alpha 1 antitrypsin in serum of Thoroughbred foals. A total of 624 samples, collected from 39 foals were obtained in monthly intervals from first to 16 month of life and measured by STIC method (specific trypsin inhibitory captivity). The obtained results indicated the significant impact of analyzed age periods on the AAT level. Furthermore, the variation in AAT level in analyzed periods corresponded to significant changes in foals diet and maintaining. Alpha 1 antitrypsin concentration was also affected by sire effects and sex of foals. In the most investigated age periods, the impact of sire on alpha 1 antitrypsin content in serum of his progeny has been shown. The obtained results might be useful in explanation of differences in serum AAT concentration in foals during early ontogenesis which probably is a critical period that has an influence on racing performance of young horses.

PL

Wpływ różnych czynników na poziom alfa-1-antytrypsyny u źrebiąt pełnej krwi angielskiej. Białka ostrej fazy (APP) są integralną częścią tzw.: odpowiedzi ostrej fazy na stan zapalny. Alfa-1-antytrypsyna (ATT) jest uważana za jedno najważniejszych białek ostrej fazy aktywowane przez uraz, stres lub procesy zapalne. W związku z tym celem niniejszego badania była ocena wpływu różnych czynników (płeć, miesiąc życia i ojciec) na stężenia ATT w surowicy krwi źrebiąt pełnej krwi angielskiej. Materiał do badań stanowiło 624 próbek kri, zebranych od 39 źrebiąt będących potomstwem czterech ogierów, uzyskanych w odstępach miesięcznych od pierwszego do 16 miesiąca życia. Stężenie ATT oznaczono metodą STIC. Uzyskane wyniki wskazały na znaczący wpływ wieku źrebiąt na poziom AAT. Co więcej, różnice w poziomie AAT w analizowanych okresach przypadały w okresach znaczących zmian u źrebiąt. Ponadto w większości badanych okresów, wykazano wpływ ojca na stężenie ATT u potomstwa. Uzyskane wyniki mogą być przydatne w celu wyjaśnienia różnic w koncentracji AAT w surowicy krwi u źrebiąt w okresie wczesnej ontogenezy która jest krytycznym okresem, mającym wpływ na wyniki użytkowe młodych koni.

• Wydawca: -
• Czasopismo: Annals of Warsaw University of Life Sciences - SGGW. Animal Science
• Rocznik: 2016
• Tom: 55[1]
• Opis fizyczny: p.69-80,fig.,ref.

Twórcy

autor

Kulisa M.

• Department of Horse Breeding, University of Agriculture in Krakow, Krakow, Poland

autor

Ormian M.

• Department of Cattle Breeding, University of Agriculture in Krakow, Krakow, Poland

autor

Stefaniuk-Szmukier M.

• Department of Horse Breeding, University of Agriculture in Krakow, Mickiewicza 24/28, 30-059 Krakow, Poland

autor

Ropka-Molik K.

• Department of Genomics and Animal Molecular Biology, National Research Institute of Animal Production, Poland

autor

Jagusiak W.

• Department of Genetics and Animal Breeding, University of Agriculture in Krakow, Krakow, Poland

autor

Podstawski Z.

• Department of Horse Breeding, University of Agriculture in Krakow, Krakow, Poland

Bibliografia

• APTER R.C., HOUSEHOLDER D.D., 1996: Weaning and weaning management of foals. A review and some recommendations. J. Equine Vet. Sci. 16: 428-435.
• BORNHORST J.A., CALDERON F.R.O., PROCTER M., TANG W., ASHWOOD E.R., MAO R., 2007: Genotypes and serum concentrations of human alpha 1-antitrypsin “P” protein variants in a clinical population. J. Clin. Pathol. doi 10.1136/jcp.2006.042762.
• BORNHORST J.A, GREENE D.N., ASHWOOD E.R., GRENACHE D.G., 2013: a1-Antitrypsin phenotypes and associated serum protein concentrations in a large clinical population. Chest. doi 10.1378/chest.12-0564.
• BROMMER H., SLOET Van OLDRUITEN- BORGH OOSTERBAAN M.M., KESSELS B. , 2001: Haematology: Haematological and blood biochemical characteristics of Dutch warmblood foals managed under three different rearing conditions from birth to 5 months of age. Vet. Quart. 23: 92-95.
• CEBULJ-KADUNC N., BOZIC M., KOSEC M., CESTNIK V, 2002: The Influence of Age and Gender on Haematological Parameters in Lipizzan Horses. J. Vet. Med. Series A 49: 217-221.
• CRAY C., ZAIAS J., ALTMAN N.H., 2009: Acute Phase Response in Animals. A Review. Comp. Med. 6: 517-526.
• DAGLEISH M.P, BRAZIL T.J., SCUDAMORE C. L., 2003: Potentation of the extracellu­lar release of equine neutrophil elastase and alpha-1-proteinase inhibitor by a combination of two bacterial cell wall components, fMLP and LPS. Equine Vet. J. 35: 35-39.
• DAGLEISH M.P, JAHAM C., SUPRENANT S., SCUDAMORE L.C., 2000: Serum alpha1- proteinase inhibitor concentration in 2 Qu­arter Horse foals with idiopathic pyogranulomatous panniculitis. Equine Vet. J. 32: 449-452.
• DAGLEISH M.P., PEMBERTON A.D., McA­LEESE S.M., THORNTON E.M., MILLER H.R., SCUDAMORE C.L., 1998: Improved hepatic and pancreatic localisation of the equine alpha-1-proteinase inhibitor family of serpins using an antigen enhancement technique and a monoclonal antibody. Res. Vet. Sci. 65: 215-221.
• DIETZ A.A., RUBINSTEIN H.M., HODGES L.K., 1976: Use of alpha-N-benzoyl-L-argi- nine-p-nitroanilide as trypsin substrate in es­timation of alpha 1-antitrypsin. Clin. Chem. 22: 1754-1755.
• DUESTERDIECK-ZELLMER K., SEME VO­LOS S., KINSLEY M., RIDDICK T., 2014: Age-related differential gene and protein expression in postnatal cartilage canal and osteochondral junction chondrocytes. Gene Expr. Patterns. 17: 1-10.
• ECKERSALL P.D., 1995: Acute phase proteins as markers of inflammatory lesions. Comp. Haematol. Int. 5: 93-97.
• FUREIX C., JÉGO P., HENRY S., LANSA- DE L., HAUSBERGER M., 2012: Towards an ethological animal model of depression? A study on horses. PLoS ONE 7,e39280. doi 10.1371/journal.pone.0039280.
• HUGHES D., ELLIOTT D.A., WASHABAU R.J., KUEPPERS F 1995: Effects of age, sex, reproductive status, and hospitalization on serum alpha 1-antitrypsin concentration in dogs. Am. J. Vet. Res. 56: 568-572.
• An Introduction to a General Stud Book, 1791. Weatherby and Sons, London.
• JANOF A., 1985: Elastase in tissue injury. Ann. Rev. Med. 36: 207-216.
• LEPEULE J., BAREILLE N., ROBERT C., EZANNO P., VALETTE J.P., JACQUET S., BLANCHARD G., DENOIX J.M., SE- EGERS H., 2009: Association of growth, feeding practices and exercise conditions with the prevalence of Developmental Orthopaedic Disease in limbs of French foals at weaning. Prev. Vet. Med. 89: 167-177.
• MALINOWSKI K., HALLQUIST N.A., HELY- AR L., SHERMAN A.R., SCANES C.G., 1990: Effect of different separation protocols between mares and foals on plasma cortisol and cell-mediated immune response. J. Equ­ine Vet. Sci. 10: 363-368.
• MARTI E., GERBER H., ESSICH G., OULEH- LA J., LAZARY S., 1991: The genetic basis of equine allergic diseases. 1. Chronic hypersensitivity bronchitis. Equine Vet. J. 23: 457-60.
• McGIVNEY B.A., EIVERS S.S., MacHUGH D. E., MacLEOD J.N., O’GORMAN G.M., PARK S.D., KATZ L.M., HILL E.W., 2009: Transcriptional adaptations following exer­cise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy. BMC Genomics 10, 638. doi 10.1186/1471-2164-10-638.
• MUÑOZ A., RIBER C., TRIGO P., CASTEJÓN F., 2012: Age- and gender-related variations in hematology, clinical biochemistry, and hormones in Spanish fillies and colts. Res. Vet. Sci. 93: 943-949.
• NUNOKAWA Y, FUJINAGA T., TAIRA T., OKUMURA M., YAMASHITA K., TSU- NODA N., HAGIO M., 1993: Evaluation of Serum Amyloid A Protein as an Acute-Phase Reactive Protein in Horses. J. Vet. Med. Sci. 55: 1011-1016.
• PALTRINIERI S., GIORDANO A., VILLA- NI M., MANFRIN M., PANZANI S., VE- RONESI M.C., 2008: Influence of age and foaling on plasma protein electrophoresis and serum amyloid A and their possible role as markers of equine neonatal septicaemia. Vet. J. 176: 393-396.
• PATTERSON S.D., BELL K., 1989: Application of an affinity electrophoretic and in situ oxidation method to the study of the equine protease inhibitory proteins. Electrophoresis. 10: 40-45.
• PATTERSON S.D., BELL K., SHAW D.C., 1991: The equine major plasma serpin multigene family, partial characterization including se­quence of reactive-site regions. Bioch. Genet. 29: 477-499.
• PELLEGRINI A., 1994: Proteinase inhibitors in animal blond with special regard to equine pulmonary disease alpha-1-proteinase in­hibitor and alpha 2. macroglobulin. Comp. Heamatol. Int. 4, 121-129.
• POTEMPA J., WUNDERLICH J.K., TRAVIS J., 1991: Comparative properties of three func­tional different but structurally related serpin variants from horse plasma. Biochem. J. 274: 465-471.
• SATOH M., FUJINAGA T., OKUMURA M., HAGIO M., 1995: Sandwich Enzyme-Linked Immunosorbent Assay for Quantitative Measurement of Serum Amyloid A Protein in Horses. Am. J. Vet. Res. 56: 1286-1291.
• SATUÉ K., CALVO A., GARDÓN J.C., 2013: Factors Influencing Serum Amyloid Type A (SAA). Concentrations in Horses. OJVM 3: 58-66.
• SCHAPER W., 1939: Untersuchungen uber die Erblichkeit und das Wesen des Lungen­dampfes beim Pferd. Tierarztl. Rundach. 31: 595-599.
• STOCKLEY R.A., 2000: Alphal-antitrypsin deficiency. What next? Thorax. 55: 614-618. STOCKLEY R.A., TURNER A.M., 2014: a-1-An- titrypsin deficiency, clinical variability, asses­sment, and treatment. Trends Mol. Med. 20 (2): 105-115.
• WARAN N.K., CLARKE N., FARNWORTH M., 2008: The effects of weaning on the domestic horse Equus caballus. Appl. Anim. Behav. Sci. 110: 42-57.
• WU Y., FOREMAN R.C., 1991: The molecular genetics of a1 antitrypsin deficiency. Bioas-says. 13: 163-169.