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2016 | 25 | 4 |
Tytuł artykułu

Effect of spermine on liver and spleen antioxidant status in weaned rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Whereas strong antioxidant properties of spermine have been reported mostly in in vitro studies, there is lack of the in vivo studies on spermine influence conducted on mammals. The main objective of this study was to investigate the effects of different doses of spermine and the period of its supplementation on the liver and spleen antioxidant capacity in weaned rats. Male Sprague-Dawley rats at the age of 19 days received intragastrically spermine at the dose of 0.2 or 0.4 μmol · g-1 body weight for 3 or 7 days, respectively. Control rats received saline in analogical way. It was found that liver anti-superoxide anion (ASA) capacity, catalase (CAT) activity, glutathione (GSH) content and total antioxidant capacity (T-AOC) were increased in group supplemented with higher dose of spermine after 3 days, and anti-hydroxy radical (AHR) capacity was increased when treatment lasted for 7 days. In the spleen the higher spermine dose supplementation increased ASA capacity and total superoxide dismutase (T-SOD) activity (after 3 and 7 days), AHR capacity (after 7 days) and T-AOC (after 3 days) in comparison to the corresponding control groups (P < 0.05). Only in the spleen the lower spermine dose reduced lipid peroxidation level and increased CAT activity and GSH content regardless treatment duration (P < 0.05). The obtained results suggest that spermine supplementation can improve the antioxidant properties of the liver and spleen of weaned rats in a dose-, time- and tissue-dependent manner.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
25
Numer
4
Opis fizyczny
p.335-342,ref.
Twórcy
autor
  • Institute of Animal Nutrition, Sichuan Agricultural University and Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China
autor
  • Institute of Animal Nutrition, Sichuan Agricultural University and Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China
autor
  • Institute of Animal Nutrition, Sichuan Agricultural University and Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China
autor
  • Institute of Animal Nutrition, Sichuan Agricultural University and Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China
autor
  • Institute of Animal Nutrition, Sichuan Agricultural University and Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China
autor
  • Maize Research Institute, Sichuan Agricultural University, Chengdu 611130, Sichuan, China
autor
  • Institute of Animal Nutrition, Sichuan Agricultural University and Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, Sichuan, China
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-59700787-826f-4b5b-a46b-5cbf8b1c6810
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