Insulin and glucose concentration changes in newborn piglets after suckling the colostrum from insulin administered sows

• Autorzy: Nowak J.
• Języki publikacji: EN

Abstrakty

EN

Nowak J.: Insulin and glucose concentration changes in newborn piglets after sucking the colostrum from insulin administered sows. Acta Physiol. Pol. Immuno reactive insulin (IRI) concentration in sows colostrum has been previously proven to be much higher than that in blood. The experiment was carried out to show the influence of endogenous and added insulin in sows colostrum on insulinaemia and glycaemia of newborn piglets. In colostrum collected from 3 control and 5 experimental sows before loading, basal insulin concentration were 1.595 and 1.365 nM⁻¹ , respectively, and calculated for all 8 sows together were 1.451 nM⁻¹ (SEM ± 0.289). Basal plasma insulin concentrations calculated for 68 healthy piglets before sucking were little differentiated (mean 0.318 ± 0.044 nM I⁻¹ ), whereas glucose initial concentrations for those piglets (mean 3.581 ± 0.275 nM I⁻¹ ) were highly differentiated. Intramuscular loading of 5 experimental sows with insulin (80 I.U. per animal) caused an increase in the concentration of insulin in colostrum from 1.365 to 3.449 nM I⁻¹ (0.01, P < 0.02). The mean insulin level (0.313 + 0.04 nM I⁻¹ ) in experimental piglets blood plasma (n = 42) increased significantly to 1.234 + 0.07 (P < 0.001) after suckling by sows loaded with exogenous insulin. Glycaemic response of those two piglets litters was poor but showed a statistically significant increase (P < 0.001). The glucose concentrations in blood plasma samples of the other three litters did not changes after sucking. The experiment excluded the hypothesis that high level of insulin in colostrum could be the cause of hypoglycaemia in healthy piglets after sucking.

Słowa kluczowe

EN

insulin; glucose concentration; concentration change; newborn; piglet; suckling; colostrum; sow

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1990
• Tom: 41
• Numer: 7
• Opis fizyczny: p.155-162,ref.

Twórcy

autor

Nowak J.

• Department of Experimental Pathology of Animals, Polish Academy of Sciences, Grunwaldzka 250, 60-166 Poznan, Poland

Bibliografia

• 1. Alais C., Jolles P. (1961): Etude comparee des caseinoglycopeptides formes par action de la prćsure sur les caseines de vache, de brebis et chevre. Biochim. Biophys. Acta, 51, 315-322.
• 2. Anysley-Green A. (1982): Hypoglycaemia in infants and children. In Clinics in Endocrinology and Metabolism, eds. J. D. Bailey. Ansley-Green, pp. 159—194, W. B. Saunders Co., London, Philadelphia, Toronto.
• 3. Ballard F. J. (1978): Carbohydrate metabolism and the regulation of blood glucose. In Perinatal Physiology, eds. U. Stave. Ballard, pp. 365-379, Plenum Medical Book Co., New York-London.
• 4. Brenner K. V., Schultze B., Gürtler H., Müller I. (1981): Fructose tolerance and insulin response of swine to massive intravenous fructose injection. Arch, exper. Vet. med., Leipzig 6, 845-854.
• 5. Brenner K. V., Gürtler H., Schmidt G. (1982): Dose-dependent action of insulin on parameters of carbohydrate and lipid metabolism in blood plasma of swine. Arch, exper. Vet. med., Leipzig 36, 269-278.
• 6. Gürtler H., Stöhr J., Brenner K. V. (1980): Age-dependente of fructose and galactose tolerances, following massive intravenous injections of piglets. Arch, exper. Vet. med., Leipzig 34, 767-775.
• 7. Koldovsky O. (1978): Digestion and absorption. In Perinatal Physiology, eds. U. Stave. Koldovsky, pp. 317-346, Plenum Medical Book Co., New York- London.
• 8. Koldovsky O. (1980): Hormones in milk. Life Science, 26, 1833-1936.
• 9. Kupski A., Kolb E., Böhme A., Gründel G., Schineff C. (1983): Testing of sows and newborn piglets for haemoglobin levels in blood plasma and glucose in blood plasma. Mh. Vet.-Med., 38, 452-457.
• 10. Kulski J. K., Hartmann P. E. (1983): Milk insulin, GH, and TSH: Relationship to changes in milk lactose, glucose and protein during lactogenesis in women. Endocr. Exper., 17, 317-326.
• 11. Nowak J., Staszak B., Ślebodziński A. B. (1980): The radioimmunological determination of the insulin level in the early postnatal period in the pig. Medycyna Wet., 36, 693-696.
• 12. Nowak J., Nowak J. (1989): The observation of perinatal changes of insulin concentration in colostrum and milk of women, cows and sows. Acta Physiol. Pol., 40, 349-355.
• 13. Nowak J. (1989): The influence of insulin loading tests per os on insulin and glucose concentrations in blood of piglets within 40 hours from birth. Arch, exper. Vet. med., Leipzig 43, 67-72.
• 14. Oktaba W. (1974): Elementy statystyki matematycznej i metodyka doświadczalnictwa. PWN, Warszawa.
• 15. Rogulski J. (1980): Metody enzymatyczne oraz metody oznaczania glukozy, barwników żółciowych i niektórych składników krwi. In Biochemia Kliniczna i Analityka, eds. S. Angielski. Rogulski, pp. 364-404, PZWL, Warszawa.
• 16. Swenson M. J. (1978): Composition of body fluids. In Diseases of Swine, eds. H. W. Dunne & A. D. Leman. Swenson, pp. 92-121, The Iowa State University Press, Ames, Iowa, U.S.A.
• 17. Ślebodziński A. B., Nowak J., Gawęcka H., Sechman A. (1986): Thyroid hormones and insulin in milk; A. comparative study. Endocr. Exper., 20, 247-255.
• 18. Tildon J. T., Świątek К. В. R., Corblath M. (1971): Phosphoenolpyruvate carboxykinase in the developing pig liver Biol. Neonate, 17, 436-442.
• 19. Umbach R., Kolb E., Gründel G., Schineff Chr., Schmidt U., Valentin C. 1984): Studies into levels of free fatty acids, fructose, lactate and total alpha-amino nitrogen in blood plasma of sows and piglets, prior to uptake of colostrum. Archiv, exper. Vet. med., Leipzig 38, 583-607.