Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2012 | 68 | 03 |

Tytuł artykułu

Biogeneza kuleczek tłuszczowych mleka

Warianty tytułu

Biogenesis of the milk fat globules

Języki publikacji



Processes of milk fat biosynthesis and milk fat globules secretion are gaining increasing attention in recent years. Milk fat not only provides calories and nutritionally important components, but also greatly contributes to the organoleptic characteristics of dairy products. Milk fat globules are formed and secreted from mammary epithelial cells. The functioning and development of the mammary gland is a very complex process. The changes in hormonal levels upon each pregnancy cause the mammary epithelial cells to proliferate, differentiate and die due to apoptosis. The paper brings together current information regarding the regulation of the mammary gland development, regulation of milk fat synthesis, as well as characterizes key stages in the biosynthesis, formation and secretion of milk fat globules.








Opis fizyczny



  • Katedra Mleczarstwa i Zarządzania Jakością, Wydział Nauki o Żywności, Uniwersytet Warmińsko-Mazurski w Olsztynie, ul.Oczapowskiego 7, 10-719 Olsztyn


  • 1.Anderson S. M., Rudolph M. C., McManaman J. L., Neville M. C.: Secretory activation in the mammary gland: it's not just about milk protein synthesis. Breast Cancer Res. 2007, 9, 204.
  • 2.Aoki N.: Regulation and functional relevance of milk fat globules and their components in the mammary gland. Biosci. Biotechnol. Biochem. 2006, 70, 2019-2027.
  • 3.Ashbrook J. D., Spector A. A., Santos E. C., Fletcher J. E.: Long chain fatty acids binding to human plasma albumin. J. Biol. Chem. 1975, 250, 2333-2338.
  • 4.Bauman D. E., Mather I. A., Wall R. J., Lock A. L.: Major advances associated with the biosynthesis of milk. J. Dairy Sci. 2006, 89, 1235-1243.
  • 5.Bionaz M., Loor J. J.: Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics 2008, 9, 366.
  • 6.Bolanos-Garcia V. M., Miguel R. N.: On the structure and function of apolipoproteins: more than a family of lipid-binding proteins. Prog. Biophys. Mol. Bio. 2003, 83, 47-68.
  • 7.Brown M. S., Goldstein J. L.: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89, 331-340.
  • 8.Cella N., Groner B., Hynes N. E.: Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocorticoid receptor in mammary cells. Mol. Cell. Biol. 1998, 18, 1783-1792.
  • 9.Fielding B. A., Frayn K. N.: Lipoprotein lipase and the disposition of dietary fatty acids. Brit. J. Nutr. 1998, 80, 495-502.
  • 10.Franke W. W., Schmidt E., Freudenstein C., Appelhans B., Osborn M., Weber K., Keenan T. W.: Intermediate-sized filaments of the prekeratin type in myoepithelial cells. J. Cell Biol. 1980, 84, 633-654.
  • 11.Ghosal D., Shappell, Keenan T. W.: Endoplasmic reticulum lumenal proteins of rat mammary gland. Potential involvement in lipid droplet assembly during lactation. Biochim. Biophys. Acta 1994, 1200, 175-181.
  • 12.Gouilleux F., Wakao H., Mundt V., Groner B.: Prolactin induces phosphorylation of Tyr694 of STAT5 (MFG), a prerequisite for DNA binding and induction of transcription. EMBO J. 1994, 13, 4361-4369.
  • 13.Heid H. W., Keenan T. W.: Intracellular origin and secretion of milk fat globules. Eur. J. Cell Biol. 2005, 84, 245-258.
  • 14.Horton J. D., Goldstein J. L., Brown M. S.: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002, 109, 1125-1131.
  • 15.Keenan T. W.: Milk lipid globules and their surrounding membrane: A brief history and perspectives for future research. J. Mammary Gland Biol. Neoplasia 2001, 6, 365-371.
  • 16.Koletzko B., Rodriguez-Palermo M., Demmelmair H., Fidler N., Jensen R., Sauerwald T.: Physiological aspects of human milk lipids. Early Hum. Dev. 65 Suppl., 2001, 3-18.
  • 17.Lebrun J. J., Ali S., Sofer L., Ullrich A., Kelly P. A.: Prolactin-induced proliferation of Nb2 cells involves tyrosine phosphorylation of the prolactin receptor and its associated tyrosine kinase JAK2. J. Biol. Chem. 1994, 269, 14021-14026.
  • 18.Lemay D. G., Neville M. C., Rudolph M. C., Pollard K. S., German J. B.: Gene regulatory networks in lactation: identification of global principles using bioinformatics. BMC Syst. Biol. 2007, 1, 56.
  • 19.Lollivier V., Guinard-Flament J., Ollivier-Bousquet M., Marnet P. G.: Oxytocin and milk removal: to important sources of variation in milk production and milk quality during and between milking. Reprod. Nutr. Dev. 2002, 42, 173-186.
  • 20.Mather I. H., Keenan T. W.: Origin and secretion of milk lipids. J. Mammary Gland Biol. Neoplasia 1998, 3, 259-273.
  • 21.McArthur M. J., Atshaves B. P., Frolov A., Foxworth W. D., Kier A. B., Schroeder F.: Cellular uptake and intracellular trafficking of long chain fatty acids. J. Lipid Res. 1999, 40, 1371-1383.
  • 22.McManaman J. L., Russell T. D., Schaack J., Orlicky D. J., Robenek H.: Molecular determinants of milk lipid secretion. J. Mammary Gland Biol. Neoplasia 2007, 12, 259-268.
  • 23.Nickerson S. C., Keenan T. W.: Distribution and orientation of microtubules in milk secreting epithelial cells of rat mammary gland. Cell Tissue Res. 1979, 202, 303-312.
  • 24.Ollivier-Bousquet M., Devinoy E.: Physiology of lactation: Old questions, new approaches. Livest. Prod. Sci. 2005, 98, 163-173.
  • 25.Rogers M. P., Zhao X.: Lipoprotein lipase mRNA levels in adipose tissue in lactation. Biochem. Soc. Trans. 1996, 24, 169S.
  • 26.Rudolph M. C., McManaman J. L., Phang T., Russell T., Kominsky D. J., Serkova N. J., Stein T., Anderson S. M., Neville M. C.: Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. Physiol. Genomics 2007, 28, 323-336.
  • 27.Sinha Y. N.: Structural variants of prolactin: occurence and physiological significance. Endocr. Rev. 1995, 16, 354-369.
  • 28.Spitsberg V. L.: Bovine milk fat globule membrane as a potential nutraceutical. J. Dairy Sci. 2005, 88, 2289-2294.
  • 29.Sundqvist A., Goechea-Alonso M. T., Ye X., Lukiyanchuk V., Jin J., Harper J. W., Ericsson J.: Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCFFbw7. Cell Metab. 2005, 1, 379-391.
  • 30.Uchide T., Onda K., Bonkobara M., Thongsong B., Matsuki N., Inaba M., Ono K.: Utilization of intestinal trigliceride-rich lipoproteins in mammary gland of cows. J. Vet. Med. Sci. 1999, 61, 1143-1146.
  • 31.Wan Y., Saghatelian A., Chong L. I., Zhang C. L., Cravatt B. F., Evans R. M.: Maternal PPAR ã protects nursing neonates by suppressing the production of inflammatory milk. Gene Dev. 2007, 21, 1895-1908.
  • 32.Wu C. C., Howell K. E., Neville M. C., Yates III J. R., McManaman J. L.: Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells. Electrophoresis 2000, 21, 3470-3482.

Typ dokumentu



Identyfikator YADDA

JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.