Fatty foci within the heart and the accompanying changes in the coronary arteries diagnosed in electrocardiogram-gated multislice computed tomography of the heart

• Autorzy: Tomaszewska M. , Czekajska-Chehab E. , Olchowik G. , Tomaszewski M. , Drop A.
• Języki publikacji: EN

Abstrakty

EN

Background: The purpose of our study was to analyse the relationship between fatty foci within the heart and the accompanying changes in the coronary arteries supplying the relevant heart chambers in a large group of patients referred to multi-slice computed tomography with electrocardiogram-gating examinations (ECG-MSCT) for various clinical reasons. Materials and methods: The ECG-MSCT examinations of 1,830 consecutive patients were analysed. The examinations were performed using 8-row (1,015 patients) and 64-row (815 patients) MSCT, in pre- and postcontrast scanning. In the group of patients with fatty foci within the heart the concomitant changes in the coronary arteries were assessed. It was analysed: the type of changes in the arteries; the relationship between the locations of the fatty deposits and the occurrence and type of changes in the coronary arteries. Results: In 200 (10.9%) subjects fatty foci within the heart (112 men; 88 women; mean age 57.8) were detected. The distribution of the fat was as follows: right ventricle (RV) — 32.5%, left ventricle (LV) — 22.0%, biventricular — 45.5%. One hundred and seventy-two patients had concomitant changes in the coronary arteries. In patients with normal coronary arteries, significantly more often fatty deposits were localised within RV. Fat was primarily located subendocardially in the LV in patients with atherosclerosis in the left anterior descending artery (p < 0.001), in the right coronary artery (RCA) (p = 0.003), and in the left circumflex artery (LCX) (p < 0.001). Subpericardial locations of fatty deposits in RV significantly correlated with RCA bridging (p < 0.02); the subpericardial location of fat in LV significantly correlated with LCX bridging (p = 0.001). Conclusions: Fatty replacement of the myocardium is common, occurring in up to 10% of diagnosed patients and the majority of this group had concomitant changes in the coronary arteries. However, in the group of patients without changes in the coronary arteries, the fatty deposits locate themselves significantly more frequently within the RV. (Folia Morphol 2014; 73, 4: 445–461)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2014
• Tom: 73
• Numer: 4
• Opis fizyczny: p.455-461,fig.,ref.

Twórcy

autor

Tomaszewska M.

• 1st Department of Radiology, Medical University of Lublin, Lublin, Poland

autor

Czekajska-Chehab E.

• 1st Department of Radiology, Medical University of Lublin, Lublin, Poland

autor

Olchowik G.

• Department of Biophysics Medical University of Lublin, Lublin, Poland

autor

Tomaszewski M.

• Department of Human Anatomy Medical University of Lublin, Lublin, Poland

autor

Drop A.

• 1st Department of Radiology, Medical University of Lublin, Lublin, Poland

Bibliografia

• 1. Adriaensen ME, Schaefer-Prokop CM, Duyndam DA, Zonnenberg BA, Prokop M (2009) Fatty foci in the myocardium in patients with tuberous sclerosis complex: common finding at CT. Radiology, 253: 359–363.
• 2. Baroldi G, Silver MD, De Maria R, Parodi O, Pellegrini A (1997) Lipomatous metaplasia in left ventricular scar. Can J Cardiol, 13: 65–71.
• 3. Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R, Nadal-Ginard B, Silvestri F, Leri A, Beltrami CA, Anversa P (2001) Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med, 344: 1750–1757.
• 4. Bronzini E, Novi AM (1959) Contributo anatomopatologico allo studio del cuore adiposo Studio su 100 casi. Arch Maragliano, 15: 1045–1070.
• 5. Hori Y, Funabashi N, Uehara M, Ueda M, Takaoka H, Nakamura K, Murayama T, Komuro (2010) Positive influence of aging on the occurrence of fat replacement in the right ventricular myocardium determined by multislice-CT in subjects with atherosclerosis. Int J Cardiol, 142: 152–158.
• 6. Imada M, Funabashi N, Asano M, Uehara M, Hori Y, Ueda M, Komuro I (2007) Epidemiology of fat replecement of the right ventricular myocardium determined by multislice computed tomography using a logistic regression model. Int J Cardiol, 119: 410–413.
• 7. Jacobi AH, Gohari A, Zalta B, Stein MW, Haramati LB (2007) Ventricular myocardial fat: CT findings and clinical correlates. J Thorac Imaging, 22: 130–135.
• 8. Kiès P, Bootsma M, Bax J, Schalij MJ, van der Wall EE (2006) Arrhythmogenic right ventricular dysplasia/ cardiomyopathy: screening, diagnosis, and treatment. Heart Rhythm, 3: 225–234.
• 9. Kim E, Choe YH, Han BK, Kim SM, Kim JS, Park SW, Sung J (2007) Right ventricular fat infiltration in asymptomatic subjects: observations from ECG-gated 16-slice multidetector CT. J Comput Assist Tomogr, 31:22–28.
• 10. Kimura F, Matsuo Y, Nakajima T, Nishikawa T, Kawamura S, Sannohe S, Hagiwara N, Sakai F (2010) Myocardial fat at cardiac imaging: how can we differentiate pathologic from physiologic fatty infiltration? Radiographics, 30: 1587–1602.
• 11. Kirsch J, Johansen CK, Araoz PA, Brady PA, Williamson EE, Glockner JF (2010) Prevalence of fat deposition within the right ventricular myocardium in asymptomatic young patients without ventricular arrhythmias. J Thorac Imaging, 25: 173–178.
• 12. Marcus FI, Fontaine GH, Guiraudon G, Frank R, Laurenceau JL, Malergue C, Grosgogeat Y (1982) Right ventricular dysplasia: a report of 24 adult cases. Circulation, 65: 384–398.
• 13. McKenna WJ, Thiene G, Nava A, Fontaliran F, Blomstrom-Lundqvist C, Fontaine G, Camerini F (1994) Diagnosis of arrhythmogenic riht ventricular dysplasia/ cardiomyopathy. Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council an Cardiomyopathies of the International Society and Federation of Cardiology. Br Heart J, 71: 215–218.
• 14. Raney AR, Saremi F, Kenchaiah S, Gurudevan SV, Narula J, Narula N, Channual S (2008) Multidetector computed tomography shows intramyocardial fatdeposition. J Cardiovasc Comput Tomogr, 2: 152–163.
• 15. Su L, Siegel JE, Fishbein MC (2004) Adipose tissue in myocardial infarction. Cardiovasc Pathol, 13: 98–102.
• 16. Uehara M, Takaoka H, Ozawa K, Kobayashi Y, Funabashi N (2013) Clinical significance of fat infiltration in the moderator band and right ventricular myocardium in multislice CT, and its association with abnormal conduction seen in electrocardiogram. Int J Cardiol, 168: 352–356.
• 17. Winer-Muram HT, Tann M, Aisen AM, Ford L, Jennings SG, Bretz R (2004) Computed tomography demonstration of lipomatous metaplsia of left ventricle following myocardial infarction. J Computed Assist Tomogr, 28: 455–458.
• 18. Zafar HM, Litt DA, Torigian DA (2007) CT imaging features and frequency of left ventricular myocardial fat in patients with CT findings of chronic left ventricular myocardial infarction. Clin Radiol, 63: 256–262.

Identyfikatory

DOI

10.5603/FM.2014.0068