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2017 | 12 |

Tytuł artykułu

G6PD activity in malaria infected children in Owerri

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
This paper is a study of G6PD activity in malaria-infected children in Owerri. Blood samples were collected from fifty-one (51) children hospitalized in the Federal Medical Center (FMC) and analyzed using standard Medical Laboratory methods. Results revealed that out of the 51 children examined (26 males and 25 females), 39, representing 76.47% of the total malaria infected children numbers, were G6PD deficient, while 12, representing 23.53%, had normal G6PD. Two different plasmodium species and their percentage occurrences were observed. These were: Plasmodium falciparum (78.43%) and Plasmodium malariae (21.57%). The work indicated that male children were more (P < 0.05) deficient than females, with percentage levels of 61.53% and 38.47%, respectively. In addition, children between the ages of 49-60 months was observed to be more (P < 0.05) G6PD deficient (with percentage of 25.64%), while those between 0-12 months were least G6PD deficient (with percentage of 8.3% (P < 0.05)). As being afflicted with malaria carries a high risk of Glucose-6-phosphate dehydrogenase (G6PD) deficiency in children, there is, therefore, urgent need for public enlightenment on public health implications, need for proper hygiene, as well as a need for strategies for preventing and controlling mosquito populations

Słowa kluczowe

Wydawca

-

Rocznik

Tom

12

Opis fizyczny

p.63-72,fig.,ref.

Twórcy

autor
  • Department of Microbiology, Federal University of Technology, Owerri, Imo State, Nigeria
  • Department of Microbiology, Imo state University, Owerri, Imo State, Nigeria
autor
  • Department of Microbiology, Imo state University, Owerri, Imo State, Nigeria
  • Department of Microbiology, Federal University of Technology, Owerri, Imo State, Nigeria
  • Department of Microbiology, Imo state University, Owerri, Imo State, Nigeria
autor
  • Department of Microbiology, Federal University of Technology, Owerri, Imo State, Nigeria
  • Department of Microbiology, Federal University of Technology, Owerri, Imo State, Nigeria
autor
  • Department of Chemistry, Imo state University, Owerri, Imo State, Nigeria

Bibliografia

  • [1] Reclos, G., Hatzidakis, C. and Schulpis, K. (2000). Glucose-6-phosphate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficient female neonates are missed during routine screening. Journal of Medical Screening 7(1), 46-51
  • [2] Noori-Daloii, M., Najafi, L., Ganji, S., Hajebrahimi, Z. and Sanati, M. (2004). Molecular identification of mutations in G6PD gene in patients with favism in Iran. Journal of physiology and biochemistry 60(4), 273-277
  • [3] Frank, J. (2005): Diagnosis and management of G6PD deficiency. Journal American family physician 72(7), 1277
  • [4] Beutler, E. (1993). The study of glucose-6-phosphate dehydrogenase. History and molecular biology 33(6), 78-81
  • [5] Glader, B. and Lukens, J. (1999). Glucose-6-phosphate dehydrogenase deficiency and related disorders of hexose monophosphate shunt and glutathione metabolism. Wintrobe’s Clinical hematology, 1, 1176-1190
  • [6] Ruwende C & Hill A (1998) Glucose-6-phosphate dehydrogenase deficiency and malaria. J. Mol. Med. (Berl) 76( 8):581-588.
  • [7] Moskaug, J., Carlsen, H., Myhrstad, M. and Blomhoff, R. (2004). Molecular imaging of the biological effects of quercetin and quercetin-rich foods. Mechanisms of ageing and development 125(4), 315-324
  • [8] Cheesbrough, M. (2006). District laboratory practice in tropical countries, 2nd Ed. Update part 1, Pp. 256, 350-352
  • [9] Ninokata, A., Kimura. R., Samakkarn, U., Settheetham-Ishida, W. and Ishida, T. (2006): Coexistence of five G6PD variants indicates ethnic complexity of Phuket islanders, Southern Thailand. J. Hum. Genet. 51(5):424-428.
  • [10] White, N. (2008). The role of anti-malarial drugs in eliminating malaria. Malar J 7(1), S8
  • [11] Hoyer, S., Nguon, S., Kim, S., Habib, N., Khim, N., Sum, S., Christophel, E., Bjorge, S., Thomson, A., Kheng, S., Chea, N., Yok, S., Top, S., Ros, S., Sophal, U., Thompson, M., Mellor, S., Ariey, F., Witkowski, B., Yeang, C., Yeung, S, Duong S, Newman RD, Ménard D: Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia. PLoS One 7(45), 797
  • [12] Mason, P., Stevens, D., Luzzatto, L., Brenner, S. and Aparicio, S. (1995). Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD). Genomics 26(3), 587-591
  • [13] Koehler, A. and Van-Noorden, C. (2003). Reduced nicotinamide adenine dinucleotide phosphate and the higher incidence of pollution-induced liver cancer in female flounder. American Journal of Physical Anthropology 23(34), 67-89
  • [14] Opeyemi R. Salau, Taofeek Ewumi, Bunmi E. Owolabi, Gabriel O. Ajayi, Oluwaseun E. Ajayi. Regional Distribution of Malaria in Ekiti State, Nigeria. World Scientific News 55 (2016) 89-100

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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