Effect of calcium and magnesium in diet on the experimental hypertension

• Autorzy: Ziemlanski S. , Wartanowicz M. , Potrzebnicka K. , Zelakiewicz

Warianty tytułu

PL

Wpływ wapnia i magnezu w diecie na eksperymentalne nadciśnienie tętnicze

• Języki publikacji: EN

Abstrakty

EN

In 142 Wistar rats fed high (30% kcal) or low (7% kcal) fat diet the effect of various amounts of magnesium and calcium on blood pressure was studied. The animals were divided into 19 groups consisting of 6—8 rats, which consumed experimental or control diet for 6 weeks. Two experiments were performed on the high fat diet. In experiment I six groups of animals received a diet with 0.04% magnesium, 0.15% magnesium, 0.3% magnesium, 2.0% calcium, 4.0% calcium, or 0.3% magnesium + 0.9% calcium respectively. In experiment II the other six groups of animals were kept on the same diets. In the first experiment the rats drank water, in the second water with 1.5% NaCl. In experiment III, on the low fat diet, three groups of animals were fed a diet with 0.3% magnesium, 2.0% calcium or 4.0% calcium respectively. The rats drank water. A reducing blood pressure effect of magnesium, calcium and both minerals together in rats fed the high fat diet in both models of experiment was found. However, it should be mentioned that the effect was more pronounced in NaCl induced arterial hypertension. The addition of these minerals to the low fat diet did not influence blood pressure. Diet supplementation with calcium and/or magnesium influenced ascorbic acid metabolism by decreaseing urine output and increasing its content in some tissues. Rats with experimental hypertension excreated greater amounts of PGF2 in urine in relation to the control group.

PL

Badano wpływ wapnia i magnezu na ciśnienie tętnicze krwi u 142 szczurów Wistar, żywionych przez okres 6 tygodni dietą bogatotłuszczową (30% kcal) lub niskotłuszczową (7% kcal). Eksperymentalne nadciśnienie tętnicze krwi wywoływano przez podawanie per os 1.5% wodnego roztworu NaCl. Przeprowadzono dwa eksperymenty na diecie bogatotłuszczowej. W eksperymencie I zwierzęta otrzymywały dietę z dodatkiem 0.04% magnezu, 0.15% magnezu, 0,3% magnezu, 2% wapnia, 4% wapnia lub 0,3% magnezu + 0,9% wapnia. W eksperymencie II zwierzętażywiono tymi samymi dietami z tym, ze do wody pitnej dodawano NaCl. W eksperymencie III, na diecie niskotłuszczowej szczury otrzymywały dietę z dodatkiem 0,3% magnezu, 2% wapnia lub 4% wapnia. Stwierdzono hipotensyjne działanie magnezu i wapnia w obu eksperymentach przeprowadzonych na diecie bogatotłuszczowej. Działanie to było bardziej widoczne u zwierząt z eksperymentalnym nadciśnieniem. Dodatek badanych składników mineralnych do diety niskotłuszczowej nie wpływał na ciśnienie krwi. Suplementacja diety wapniem lub/i magnezem wpływała na metabolizm kwasu askorbinowego poprzez zwiększenie wydalania jego z moczem oraz zwiększanie zawartości w tkankach. Szczury z eksperymentalnym nadciśnieniem tętniczym wydalały z moczem większe ilości PGF2 w porównaniu z kontrolnymi.

Słowa kluczowe

EN

blood pressure; hypertension; calcium; magnesium; diet; ascorbic acid; prostaglandin; high-fat diet

• Wydawca: -
• Czasopismo: Żywienie Człowieka i Metabolizm
• Rocznik: 1991
• Tom: 18
• Numer: 4
• Opis fizyczny: p.269-278,fig.,ref.

Twórcy

autor

Ziemlanski S.

• Department of Nutrition Physiology and Biochemistry National Food and Nutrition Institute in Warsaw, Warsaw, Poland

autor

Wartanowicz M.

• Department of Nutrition Physiology and Biochemistry National Food and Nutrition Institute in Warsaw, Warsaw, Poland

autor

Potrzebnicka K.

• Department of Nutrition Physiology and Biochemistry National Food and Nutrition Institute in Warsaw, Warsaw, Poland

autor

Zelakiewicz

• Department of Nutrition Physiology and Biochemistry National Food and Nutrition Institute in Warsaw, Warsaw, Poland

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