Benign hepatic tumors in association with estrogenie therapy

• Autorzy: Radzikowska E. , Luszczewska-Sierakowska I. , Abramowicz K. , Sokoluk M. , Burdan F. , Madej B. , Dabrowski A. , Maciejewski R.
• Języki publikacji: EN

Abstrakty

EN

A long-term use of oral contraceptives may be responsible for an increased risk of benign hepatic tumors (hepatic adenoma, focal nodular hyperplasia (FNH), hemangioma). The purpose of this study was to determine the effect of estrogen administration on the liver function and morphology. Oestradiolum benzoicum was administered intramuscularly to female rats for 8 weeks. Liver sections were collected for histological and ultrastructural examination. The most common features were as follows: nodular regenerative hyperplasia, adenomas, peliosis hepatis and fatty changes. In animals which had received higher than therapeutic doses of estrogens the following ultrastructural changes were found: mitochondrial damage, megamitochondria, diffusely distributed round spaces with blood fluid inside, fatty changes, canalicular cholestasis and steatohepatitis with Ito cells. Data derived from this model should provide more accurate information useful in recognizing hepatotoxicity of a drug during initial toxicological studies and during initial evaluations in man before widespread clinical use, as well as in determining the risk of liver tumor development.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2012
• Tom: 68
• Numer: 03
• Opis fizyczny: p.168-171,fig.,ref.

Twórcy

autor

Radzikowska E.

• Department of Human Anatomy, Medical University in Lublin, Jaczewskiego 4, 20-090 Lublin

autor

Luszczewska-Sierakowska I.

autor

Abramowicz K.

autor

Sokoluk M.

autor

Burdan F.

autor

Madej B.

autor

Dabrowski A.

autor

Maciejewski R.

Bibliografia

• 1.Anthony P. P.: Liver tumors. Billieres Clin. Gastroenterol. 1988, 2, 501-503.
• 2.Baum J. K., Holtz F., Bobkstein J. J., Klein E. W.: Possible association between benign hepatomas and oral contraceptives. Lancet 1973, 302, 926-929.
• 3.Edmondson H. A., Henderson B., Beneton B.: Liver-cell adenomas associated with use of oral contraceptives. N. Engl. J. Med. 1976, 294, 470-472.
• 4.Edmondson H. A., Reynolds T. B., Henderson B., Beneton B.: Regression of liver-cell adenomas associated with oral contraceptives. Ann. Intern. Med. 1977, 86, 180-182.
• 5.Ferrara B. E., Rutland E. D.: Liver tumor in long-term user of oral contraceptives. Adenoma 1988, 84, 107-109.
• 6.Gabriel L. P., William R. H.: Toxicology of the Liver. Taylor and Francis; Washington 1997.
• 7.Gast K., Snyder T.: Combination oral contraceptives and cancer risk. Kans. Med. 1990, 91, 201-208.
• 8.Górska P.: Principles in laboratory animals research for experimental purpose. Med. Sci. Monitor 2000, 6, 171-180.
• 9.Ishak K. G., Zimmerman H. J.: Hepatotoxic effects of the anabolic androgenic steroids. Semin. Liver Dis. 1987, 7, 230-236.
• 10.Lakomy E. A., Pajuro R., Dubaniewicz M., Jaśkiewicz K.: Focal nodular hyperplasia of the liver in young female. Pol. Merk. Lek. 2001, 66, 503-505.
• 11.Landen S., Siriser F., Bardaxoglou E., Maddern G. J., Chareton B., Campion J. P., Launois B.: Focal nodular hyperplasia of the liver. A retrospective review of 20 patients managed surgically. Acta Chir. Belg. 1993, 93, 94-97.
• 12.Mays E. T., Christopher W.: Hepatic tumors induced by sex steroids. Semin. Liver Dis. 1984, 4, 147-157.
• 13.Metzler M., Degen G. H.: Sex hormones and neoplasia: liver tumors in rodents. Arch Toxicol. Suppl. 1987, 10, 251-261.
• 14.Molleken K.: Morphology, incidence and clinical significance of changes in the liver parenchyma following use of hormonal contraceptives. Z. Gesam. Inn. Med. 1986, 15, 618-621.
• 15.Radzikowska E., Maciejewski R., Janicki K., Madej B., Wójtowicz Z.: The relationship between estrogen and the development of liver vascular disorders. Ann. Univ. Mariae Curie-Sklodowska Med. 2001, 56, 189-195.
• 16.Rosenberg L.: The risk of liver neoplasia in relation to combined oral contraceptive use. Contraception 1991, 43, 643-652.
• 17.Schaff Z., Szekely E., Jaray B., Kiss A.: Pathology of liver tumors. Orv. Hetil. 2004, 145, 368-374.
• 18.Shmid M.: Contraceptives and the liver. Leber Magen Darm 1981, 11, 216-226.
• 19.Valla D. C.: Vascular disorders of the liver. Acta Gastroenterol. Belg. 2003, 66, 294-297.
• 20.Wang S. Y., Ruggles S., Vade A., Newman B. M., Borge M. A.: Hepatic rupture caused by peliosis hepatis. J. Pediatr. Surg. 2001, 36, 1456-1459.
• 21.Zimmerman H. J., Maddrey W. C.: Toxic and drug-induced hepatitis, [in:] Schiff L., Schiff E. R.: Diseases of the Liver. Lippincott, Philadelphia 1993.

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