Comparison of effectiveness of two different artemisininbased combination therapies in an area with high seasonal transmission of malaria in Burkina Faso

• Autorzy: Sondo P. , Derra K. , Nakanabo S.D. , Tarnagda Z. , Kazienga A. , Valea I. , Sorgho H. , Ouedraogo J.-B. , Guiguemde T.R. , Tinto H.
• Języki publikacji: EN

Abstrakty

EN

In Sahelian countries such as Burkina Faso, malaria transmission is seasonal with a high incidence of transmission during the rainy season. This study aimed to compare the effectiveness of the two recommended treatments (Artemether-Lumefantrine and Artesunate-Amodiaquine) for uncomplicated malaria in Burkina Faso regarding this seasonal variation of malaria transmission. This is part of a randomized open label trial comparing the effectiveness and safety of Artemether-Lumefantrine versus Artesunate-Amodiaquine according to routine practice in Nanoro. Patients with uncomplicated falciparum malaria were recruited all year round and followed-up for 28 days. To distinguish recrudescences from new infections, dried blood spots from day 0 and day of recurrent parasitaemia were used for nested-PCR genotyping of the polymorphic loci of the merozoite surface proteins 1 and 2. Seasonal influence was investigated by assessing the treatment outcomes according to the recruitment period of the patients. Two main groups (dry season versus rainy season) were defined following the seasonal characteristics of the study area. In Artemether- Lumefantrine group, the uncorrected cure rate was 76.5% in dry season versus 37.9% in rainy season. In Artesunate- Amodiaquine group, this was 93.3% and 57.1% during dry and rainy seasons, respectively. After PCR adjustment, the cure rate decreased from 85.9% in dry season to 75.0% in rainy season in Artemether-Lumefantrine group. In Artesunate-Amodiaquine group, it was 93.3% in dry season and 80.7% during the rainy season. During the rainy season around 50% of patients had a new malaria episode by Day 28. The cure rate of both Artemether-Lumefantrine and Artesunate-Amodiaquine treatments was higher in dry season compared to rainy season due to high incidence of reinfections during the rainy season. For this reason, in addition to the curative effect, the post-treatment prophylactic effect should be taken into account in the choice of antimalarial regimens.

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2017
• Tom: 63
• Numer: 2
• Opis fizyczny: p.127-131,fig.,ref.

Twórcy

autor

Sondo P.

• Institut de Recherche en Science, Sante-Unite de Recherche Clinique de Nanoro (IRSS-URCN), BP 218 Ouagadougou CMS11, Nanoro, Burkina Faso

autor

Derra K.

• Institut de Recherche en Science, Sante-Unite de Recherche Clinique de Nanoro (IRSS-URCN), BP 218 Ouagadougou CMS11, Nanoro, Burkina Faso

autor

Nakanabo S.D.

• Centre Muraz of Bobo-Dioulasso, 01 BP 390 Bobo-Dioulasso, Burkina Faso

autor

Tarnagda Z.

• Institut de Recherche en Science, Sante-Unite de Recherche Clinique de Nanoro (IRSS-URCN), BP 218 Ouagadougou CMS11, Nanoro, Burkina Faso

autor

Kazienga A.

• Institut de Recherche en Science, Sante-Unite de Recherche Clinique de Nanoro (IRSS-URCN), BP 218 Ouagadougou CMS11, Nanoro, Burkina Faso

autor

Valea I.

• Institut de Recherche en Science, Sante-Unite de Recherche Clinique de Nanoro (IRSS-URCN), BP 218 Ouagadougou CMS11, Nanoro, Burkina Faso
• Centre Muraz of Bobo-Dioulasso, 01 BP 390 Bobo-Dioulasso, Burkina Faso

autor

Sorgho H.

• Institut de Recherche en Science, Sante-Unite de Recherche Clinique de Nanoro (IRSS-URCN), BP 218 Ouagadougou CMS11, Nanoro, Burkina Faso

autor

Ouedraogo J.-B.

• Institut de Recherche en Science, Sante-Unite de Recherche Clinique de Nanoro (IRSS-URCN), BP 218 Ouagadougou CMS11, Nanoro, Burkina Faso

autor

Guiguemde T.R.

• Centre Muraz of Bobo-Dioulasso, 01 BP 390 Bobo-Dioulasso, Burkina Faso

autor

Tinto H.

• Institut de Recherche en Science, Sante-Unite de Recherche Clinique de Nanoro (IRSS-URCN), BP 218 Ouagadougou CMS11, Nanoro, Burkina Faso
• Centre Muraz of Bobo-Dioulasso, 01 BP 390 Bobo-Dioulasso, Burkina Faso

Bibliografia

• [1] The world malaria report. 2015. WHO. http://www.who. int/malaria/publications/worldmalaria-report-2015/report/en/
• [2] Enquete nationale sur les prestations des services de sante et la qualite des donnees sanitaires - rapport final. 2012. Ministere de la Sante, Burkina Faso, DSS/DGISS. http://www.who.int/healthinfo/systems/SARA_Burkina_Faso_2012_fullreport.pdf
• [3] Bassat Q., Mulenga M., Tinto H., Piola P., Borrmann S., Menéndez C., Nambozi M., Valéa I., Nabasumba C., Sasi P., Bacchieri A., Corsi M., Ubben D., Talisuna A., D’Alessandro U. 2009. Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial. PLoS One 4: e7871. https://doi.org/10.1371/journal.pone.0007871
• [4] Tinto H., Diallo S., Zongo I., Guiraud I., Valea I., Kazienga A., Kpoda H., Sorgho H., Ouédraogo J.-B., Guiguemdé T.R., D’Alessandro U. 2014. Effectiveness of artesunate-amodiaquine vs. artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Nanoro, Burkina Faso: a non-inferiority randomised trial. Tropical Medicine and International Health 19: 469-475. doi:10.1111/tmi.12274
• [5] Sondo P., Derra K., Diallo-Nakanabo S., Tarnagda Z., Zampa O., Kazienga A., Valea I., Sorgho H., Owusu-Dabo E., Ouedraogo J.-B., Guiguemde T.R., Tinto H. 2015. Effectiveness and safety of artemetherlumefantrine versus artesunate-amodiaquine for unsupervised treatment of uncomplicated falciparum malaria in patients of all age groups in Nanoro, Burkina Faso: a randomized open label trial. Malaria Journal 14: 325. doi:10.1186/s12936-015-0843-8
• [6] Fontenille D., Lochouarn L., Diagne N., Sokhna C., Lemasson J-J., Diatta M., Konate L., Faye F., Rogier C., Trape J-F. 1997. High annual and seasonal variations in malaria transmission by anophelines and vector species composition in Dielmo, a holoendemic area in Senegal. American Journal of Tropical Medicine and Hygiene 56: 247-253.
• [7] Geiger C., Agustar H.K., Compaoré G., Coulibaly B., Sié A., Becher H., Lanzer M., Jänisch T. 2013. Declining malaria parasite prevalence and trends of asymptomatic parasitaemia in a seasonal transmission setting in north-western Burkina Faso between 2000 and 2009–2012. Malaria Journal 12: 27. doi:10.1186/1475-2875-12-27
• [8] Sondo P., Biebo B., Kazienga A., Valea I., Sorgho H., Ouedraogo J.B., Guiguemdé T.R., Tinto H. 2015. The part of malaria among febrile diseases during the dry season in Nanoro area, Burkina Faso. West African Journal of Research for Health 004: 29-32.
• [9] Derra K., Rouamba E., Kazienga A., Ouedraogo S., Tahita M.C., Sorgho H., Valea I., Tinto H. 2012. Profile: Nanoro health and demographic surveillance system. International Journal of Epidemiology 41: 1293-1301. doi:10.1093/je/dys159
• [10] Badolo A., Traore A., Jones C.M., Sanou A., Flood L., Guelbeogo W.M., Ranson H., Sagnon N.F. 2012. Three years of insecticide resistance monitoring in Anopheles gambiae in Burkina Faso: resistance on the rise. Malaria Journal 11: 232. doi:10.1186/1475-2875-11-232
• [11] World Health Organization. 2003. Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. http://www.cdc.gov/malaria/resource/pdf/drug_resistance/who2003 _monitoring.pdf
• [12] Ranford-Cartwright L.C., Taylor J., Umasunthar T., Taylor L.H., Babiker H.A., Lell B., Schmidt-Ott J.R., Lehman L.G., Walliker D., Kremsner P.G. 1997. Molecular analysis of recrudescent parasites in a Plasmodium falciparum drug efficacy trial in Gabon. Transactions of the Royal Society of Tropical Medicine and Hygiene 91: 719-724. https://doi.org/10.1016/S0035-9203(97)90539-3
• [13] Snounou G., Zhu X., Siripoon N., Jarra W., Thaithong S., Brown K.N., Viriyakosol S. 1999. Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene 93: 369-374.
• [14] Mabaso M.L., Craig M., Ross A., Smith T. 2007. Environmental predictors of the seasonality of malaria transmission in Africa: the challenge. The American Journal of Tropical Medicine and Hygiene 76: 33-38.
• [15] Altizer S., Dobson A., Hosseini P., Hudson P., Pascual M., Rohani P. 2006. Seasonality and the dynamics of infectious diseases. Ecology Letters 9: 467-484. doi:10.1111/j.1461-0248.2005.00879.x
• [16] Baird J.K., Agyei S.O., Utz G.C., Koram K., Barcus M.J., Jones T.R., Fryauff D.J., Binka F.N., Hoffman S.L., Nkrumah F.N. 2002. Seasonal malaria attack rates in infants and young children in northern Ghana. The American Journal of Tropical Medicine and Hygiene 66: 280-286. https://doi.org/10.4269/ajtmh.2002.66.280
• [17] Sagara I., Fofana B., Gaudart J., Sidibe B., Togo A., Toure S., Sanogo K., Dembele D., Dicko A., Giorgi R., Doumbo O.K., Djimde A.A. 2012. Repeated artemisinin-based combination therapies in a malaria hyperendemic area of Mali: efficacy, safety, and public health impact. The American Journal of Tropical Medicine and Hygiene 87: 50-56. https://doi.org/10.4269/ajtmh.2012.11-0649
• [18] Conrad M.D., LeClair N., Arinaitwe E., Wanzira H., Kakuru A., Bigira V., Muhindo M., Kamya M.R., Tappero J.W., Greenhouse B., Dorsey G., Rosenthal P.J. 2014. Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children. Journal of Infectious Diseases 210: 344-353. https://doi.org/10.1093/infdis/jiu141

Identyfikatory

DOI

10.17420/ap6302.96