EN
The major changes in the muscular metabolism manifest themselves in the first phase following the infection (up to about the 20th day). The main source of energy is then constituted by fat metabolism, whereas in the second one the sugar metabolism takes the upper hand. The activity of the Krebs cycle is also diminished, particularly that of fumarase enzymes, malic acid dehydrogenase and alfa-ketoglutarate decarboxylase, in contrast to the conspicuous increase in the activity of succinic oxydase, which might suggest a damage to the Keilin-Warburg system in the mitochondria.