Frequencies of HLA - DQ2 and HLA - DQ8 haplotypes in Czech and Slovak coeliac patients and the healthy population

• Autorzy: Wroblova K. , Kolorz M. , Pav I. , Horakova Z. , Filipova P. , Bartos M. , Bartosova L.
• Języki publikacji: EN

Abstrakty

EN

 Coeliac disease is an autoimmune disorder with genetic predisposition. The aim was to determine the frequency of HLA-DQ2 and HLA-DQ8 in Czech and Slovak patients and the healthy population. The study included 127 patients and 66 healthy volunteers. HLA-DQ2 was identified in 85.03% patients, and 24.24% healthy individuals (P=0.0001; OR17.7632; CI=8.4347-37.4088). HLA-DQ8 was identified in 11.81% patients and 15.5% healthy individuals. HLA-DQ8 occurred more often in HLA-DQ2-negative patients compared to HLA-DQ2-positive patients (P=0.0494; OR3.5; CI 1.0428-11.7468). At least one of the studied HLA-variants was found more often in patients than in healthy individuals (P=0.0001; OR58.8; CI 7.6856-449.8602).

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2014
• Tom: 61
• Numer: 1
• Opis fizyczny: p.191-193,ref.

Twórcy

autor

Wroblova K.

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

autor

Kolorz M.

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

autor

Pav I.

• Gastroenterological Clinic SMU and University Hospital in Bratislava-Petrzalka, Bratislava, Slovak Republic

autor

Horakova Z.

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

autor

Filipova P.

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

autor

Bartos M.

• Department of Natural Drugs, UVPS Brno, Brno, Czech Republic

autor

Bartosova L.

• Department of Human Pharmacology and Toxicology, UVPS Brno, Brno, Czech Republic

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