Glandular cardiac myxoma: case report with literature review

• Autorzy: Yuan S.-M.
• Języki publikacji: EN

Abstrakty

EN

Glandular cardiac myxoma is rare, representing only 5% of cardiac myxomas. A 51-year-old female developed embolic events caused by left atrial myxoma. She underwent myxoma resection and had an uneventful postoperative course. Histology of the resected myxoma revealed a glandular cardiac myxoma. In this article, the peculiar case was presented and the origin of cardiac myxoma was discussed. (Folia Morphol 2014; 73, 3: 374–382)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2014
• Tom: 73
• Numer: 3
• Opis fizyczny: p.374-382,fig.,ref.

Twórcy

autor

Yuan S.-M.

• 1st Hospital of Putian, Teaching Hospital, Fujian Medical University, Putian, Fujian Province, People’s Republic of China

Bibliografia

• 1. Abenoza P, Sibley RK (1986) Cardiac myxoma with glandlike structures. An immunohistochemical study. Arch Pathol Lab Med, 110: 736–739.
• 2. Acebo E, Val-Bernal JF, Gómez-Román JJ, Revuelta JM (2003) Clinicopathologic study and DNA analysis of 37 cardiac myxomas: a 28-year experience. Chest, 123: 1379–1385.
• 3. Akyıldız EÜ, Tolgay E, Öz B, Yılmaz R, Koç S (2006) Cardiac myxoma: an unusual cause of sudden death in childhood. Turkish J Pediatr, 48: 172–174.
• 4. Alarcón-Galván G, Sepúlveda-Rodríguez LA, Hernández-Batres F, Flores Gutiérrez JP, Guajardo RG, Rendón Elias FG, Quintana OB, Rodríguez JA (2010) Mixoma auricular con elementos glandulares. Patología Rev Latinoam, 48: 111–114.
• 5. Anderson WA, Dmytryk ET (1946) Primary tumor of the heart containing epithelium-like elements. Am J Pathol, 22: 337–349.
• 6. Ariza S, Rafel E, Castillo JA, Garcia-Canton JA (1978) Intracardiac heterotopia: mesenchymal and endodermal. Br Heart J, 40: 325–327.
• 7. Basso C, Valente M, Poletti A, Casarotto D, Thiene G (1997) Surgical pathology of primary cardiac and pericardial tumors. Eur J Cardiothorac Surg, 12: 730–737; discussion 737–738.
• 8. Berger MD, Schneider J, Ballmer PE, Eckhardt BP, Dommann-Scherrer C (2013) Mucin-producing adenocarcinoma arising in an atrial myxoma. Ann Diagn Pathol, 17: 104–107.
• 9. Bordalo AD, Alves I, Nobre AL, Silva F, Lemos A, Serpa C, Fernandes A, Cravino J (2012) New clinical aspects of cardiac myxomas: a clinical and pathological reappraisal. Rev Port Cardiol, 31: 567–575.
• 10. Burke AP, Virmani R (1993) Cardiac myxoma. A clinicopathologic study Am J Clin Pathol, 100: 671–680.
• 11. Cappell MS, Lapin S, Rose M (2008) Large right atrial myxoma containing gastric heterotopia presenting with dyspnea and bilateral leg edema due to pulmonary emboli and cardiovascular obstruction: the first known report of gastric heterotopia in the cardiovascular system. Dig Dis Sci, 53: 405–409.
• 12. Chan KW, Lee WT, Lam KY, Chan ACL, Fu KH (1997) Cardiac tumors in Hong Kong: a clinicopathological study of 66 cases. Int J Surg Pathol, 4: 227–232.
• 13. Chen SY, Ming YH (2010) Clinical pathological and immunohistochemical studies on 30 cardiac myxoma patients. J Rare Uncomm Dis, 17: 19–21.
• 14. Chopra P, Ray R, Singh MK, Venugopal P (2003) Cardiac myxoma with glandular elements: a histologic, histochemical, and immunohistochemical evaluation. Indian Heart J, 55: 182–184.
• 15. Curschellas E, Toia D, Borner M, Mihatsch MJ, Gudat F (1991) Cardiac myxomas: immunohistochemical study of benign and malignant variants. Virchows Arch A Pathol Anat Histopathol, 418: 485–491.
• 16. de Morais C, Falzoni R, Alves VA (1988) Myocardial infarct due to a unique atrial myxoma with epithelial-like cells and systemic metastases. Arch Pathol Lab Med, 112: 185–190.
• 17. den Bakker MA, Dinjens WN, Bekkers JA (2006) Cardiac myxoma with atypical glandular component, report of a case. Histopathology, 48: 206–208.
• 18. Deshpande A, Kumar S, Chopra P (1994) Recurrent, biatrial, familial cardiac myxomas Int J Cardiol, 47: 71–73.
• 19. Deshpande A, Venugopal P, Kumar AS, Chopra P (1996) Phenotypic characterization of cellular components of cardiac myxoma: a light microscopy and immunohistochemistry study. Hum Pathol, 27: 1056–1059.
• 20. Eckhardt BP, Dommann-Scherrer CC, Stuckmann G, Zollikofer CL, Wentz KU (2003) Giant cardiac myxoma with malignant transformed glandular structures. Eur Radiol, 13: 2099–2102.
• 21. Fine G, Morales A, Horn RC Jr (1968) Cardiac myxoma. A morphologic and histogenetic appraisal. Cancer, 22: 1156–1162.
• 22. Frishman W, Factor S, Jordan A, Hellman C, Elkayam U, LeJemtel T, Strom J, Unschuld H, Becker R (1979) Right atrial myxoma: unusual clinical presentation and atypical glandular histology. Circulation, 59: 1070–1075.
• 23. Glasser SP, Bedynek JL, Hall RJ, Hopeman AR, Treasure RL, McAllister HA Jr, Esterly JA, Manion WC, Sanford HS (1971) Left atrial myxoma. Report of a case including hemodynamic, surgical, histologic and histochemical characteristics. Am J Med, 50: 113–122.
• 24. Goldman BI, Frydman C, Harpaz N, Ryan SF, Loiterman D (1987) Glandular cardiac myxomas. Histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation. Cancer, 59: 1767–1775.
• 25. Hernández-Bringasa O, Ortiz-Hidalgoa C (2013) Características histopatológicas e inmunohistoquímicas de los mixomas cardiacos. Arch Cardiol Mex, 83: 199–208.
• 26. http://case.medlive.cn/all/case-imageology/show27611_131.html.
• 27. Isobe N, Kanda T, Sakamoto H, Morishita Y, Suzuki T, Kobayashi I (1996) Myocardial infarction in myxoma patients with normal coronary arteries: case reports. Angiolog, 47: 819–823.
• 28. Jin XZ, Qian YC, Ma HH, Zhang TH, Huang FL (1993) Morphological study of cardiac myxomas with glandular structures: Histochemical, immunohistochemical and electron-microscopic study of 26 cases. Bull Jinling Hosp, 6: 325–328, 386.
• 29. Jin XZ, Qian YC, Ma HH, Zhang TH, Huang FL (1994) Morphological study of cardiac myxomata with adenoidlike structures Med J Chin PLA, 19: 351–354.
• 30. Johansson L (1989) Histogenesis of cardiac myxomas. An immunohistochemical study of 19 cases, including one with glandular structures, and review of the literature. Arch Pathol Lab Med, 113: 735–741.
• 31. Kaneko H, Murohashi T, Katano A, Hojo H, Ishikawa S (1976) Atrial myxoma associated with multiple hamartomas. Acta Pathol Jpn, 26: 603–610.
• 32. Kelly M, Bhagwat AG (1972) Ultrastructural features of a recurrent endothelial myxoma of the left atrium. Arch Pathol, 93: 219–226.
• 33. Krikler DM, Rode J, Davies MJ, Woolf N, Moss E (1992) Atrial myxoma: a tumour in search of its origins. Br Heart J, 67: 89–91.
• 34. Lazos-Ochoa M, Cruz-Gordillo AG, Murguía-Perez M (2011) Synchronic hepatocellular carcinoma with atrial myxoma. A case report. Invest Clin, 52: 170–174.
• 35. Li Y, Pan Z, Ji Y, Sheppard M, Jeffries DJ, Archard LC, Zhang H (2003) Herpes simplex virus type 1 infection associated with atrial myxoma. Am J Pathol, 163: 2407–2412.
• 36. Lindner V, Edah-Tally S, Chakfé N, Onody T, Eisenmann B, Walter P (1999) Cardiac myxoma with glandular component: case report and review of the literature. Pathol Res Prac, 195: 267–272.
• 37. Liu Y, Xu ML (2006) Cardiac myxoma with glandular component: case report. Chin Med J (Engl), 119: 174–176.
• 38. Lloreta J, Juanpere N, Riverola A, Dallari D, Cañas MA, Pijuan L, Baró T, García P, Serrano S (2013) Cardiac myxoma with glandular differentiation: an immunohistochemical and ultrastructural study. Ultrastruct Pathol, 37: 77–82.
• 39. Luo J, Zhao GH (2001) A case of right atrial myxoma of glandular type. J China-Japan Friendship Hosp, 15: 207.
• 40. Mallick SR, Das P, Shukla B, Kothari S, Devagourou V, Ray R (2010) Right atrial myxoma with glandular differentiation: a rare entity in pediatric age group. Ann Pediatr Cardiol, 3: 159–162.
• 41. Meier MR, Dietl CA, Fischer EG, Raizada V (2005) Huge right atrial myxoma with tricuspid valve endocarditis. Chirurgia, 18: 395–398.
• 42. Miller DV, Tazelaar HD, Handy JR, Young DA, Hernandez JC (2005) Thymoma arising within cardiac myxoma. Am J Surg Pathol, 29: 1208–1213.
• 43. Moiyadi AV, Moiyadi AA, Sampath S, Kalpana SR, Mahadevan A, Shankar SK, Srikanth SG (2007) Intracranial metastasis from a glandular variant of atrial myxoma. Acta Neurochir (Wien), 149: 1157–1162.
• 44. Namura O, Saitoh M, Moro H, Watanabe H, Sogawa M, Nishikura K, Hayashi J (2007) A case of biatrial multiple myxomas with glandular structure. Ann Thorac Cardiovasc Surg, 13: 423–427.
• 45. Pernick N (2007) 22 March 2007: Case of the Week #78. http://www.pathologyoutlines.com/caseofweek/case200778.htm.
• 46. Prasenjit D, Bhaskar S, Kothari S, Devagourou V, Ruma R, Saumya M. Right atrial myxoma with glandular differentiation: a rare entity in pediatric age group. http://rockyourpaper.org/article/right-atrial-myxoma-with-glandular-differentiation-a-rare-entity-in-pediatric-age-group-747a0b911ff7cc07cba30f2998936b1c.
• 47. Pucci A, Bartoloni G, Tessitore E, Carney JA, Papotti M (2003) Cytokeratin profile and neuroendocrine cells in the glandular component of cardiac myxoma. Virchows Arch, 443: 618–624.
• 48. Pucci A, Gagliardotto P, Zanini C, Pansini S, di Summa M, Mollo F (2000) Histopathologic and clinical characterization of cardiac myxoma: review of 53 cases from a single institution. Am Heart J, 140:134–138.
• 49. Ramael M, Lemmens G, Eerdekens C, Buysse C, Deblier I, Jacobs W, van Marck E (1992) Immunoreactivity for p53 protein in malignant mesothelioma and non-neoplastic mesothelium. J Pathol, 168: 371–375.
• 50. Roskell DE, Biddolph SC (1999) Proliferating cell nuclear antigen expression grossly over-estimates cellular proliferation in cardiac myxomas, Eur J Med Res, 4: 105–106.
• 51. Sasaki K, Parwani AV, Demetris AJ, Sasatomi E (2010) Heterotopic breast epithelial inclusion of the heart: report of a case. Am J Surg Pathol, 34: 1555–1559.

Identyfikatory

DOI

10.5603/FM.2014.0056